Methods are disclosed of preparing neural tissue of the brain for subsequent electrical stimulation. For example, first, second and third electrodes may be placed in close proximity to tissue of a patient's brain. A hyperpolarizing electrical pre-pulse may be applied to the tissue through the first electrode...http://www.google.com/patents/US6892097?utm_source=gb-gplus-sharePatent US6892097 - Method of preparing neural tissue of the brain for subsequent electrical stimulation