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A system and method for continuous non-invasive glucose monitoring is disclosed. According to one embodiment of the present invention, the method includes the steps of (1) contacting a remote device to an area of biological membrane having a permeability level, the remote device comprising a sensor and a transmitter; (2) extracting the at least one analyte through and out of the area of biological membrane and into the sensor; (3) generating an electrical signal representative of a level of the at least one analyte; (4) transmitting the electrical signal to a base device; (5) processing the electrical signal to determine the level of the at least one analyte; and (6) displaying the level of the at least one analyte in real time. The system includes a remote device that includes a sensor that generates an electrical signal representative of the concentration of the at least one analyte; and a transmitter that transmits the electrical signal. The system further includes a base device...

Inventors: Scott C. Kellogg, Han Chuang, Shikha Barman, Nick Warner
Original Assignee: Sontra Medical Corporation
Current U.S. Classification: 600/365; 128/903

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Referenced by

Citing PatentFiling dateIssue dateOriginal AssigneeTitle
US7615007Mar 26, 2007Nov 10, 2009DexCom, Inc.Analyte sensor
US7775975Mar 26, 2007Aug 17, 2010DexCom, Inc.Analyte sensor
US7783333Mar 10, 2005Aug 24, 2010DexCom, Inc.Transcutaneous medical device with variable stiffness
US7857760Feb 22, 2006Dec 28, 2010DexCom, Inc.Analyte sensor
US7981034Feb 28, 2006Jul 19, 2011Abbott Diabetes Care Inc.Smart messages and alerts for an infusion delivery and management system
US8085151Jun 26, 2008Dec 27, 2011Abbott Diabetes Care Inc.Signal converting cradle for medical condition monitoring and management system
US8115635Nov 24, 2009Feb 14, 2012Abbott Diabetes Care Inc.RF tag on test strips, test strip vials and boxes
US8133178Feb 22, 2006Mar 13, 2012DexCom, Inc.Analyte sensor
US8206296Aug 7, 2006Jun 26, 2012Abbott Diabetes Care Inc.Method and system for providing integrated analyte monitoring and infusion system therapy management
US8223021Nov 24, 2009Jul 17, 2012Abbott Diabetes Care Inc.RF tag on test strips, test strip vials and boxes
US8229535Feb 20, 2009Jul 24, 2012DexCom, Inc.Systems and methods for blood glucose monitoring and alert delivery

Claims

1. A method for real time remote monitoring and display of a level of at least one analyte in a body fluid of a subject, comprising:

contacting a remote device to an area of biological membrane having a permeability level, the remote device comprising a sensor and a transmitter;

extracting the at least one analyte through and out of the area of biological membrane and into the sensor;

generating an electrical signal representative of a level of the at least one analyte;

transmitting the electrical signal to a base device; processing the electrical signal to determine the level of the at least one analyte; and
displaying the level of the at least one analyte in real time.

2. The method of claim 1, wherein the at least one analyte is glucose.

3. The method of claim 1, further comprising the step of:

increasing the permeability level of the area of biological membrane.

4. The method of claim 1, wherein the step of contacting a remote device to an area of biological membrane having a permeability level comprises:

affixing the remote device to the area of biological membrane with an adhesive.

5. The method of claim 1, wherein the step of transmitting the signal to a base device comprises:

converting the electrical signal representative of the level of the at least one analyte to a digital signal; and

transmitting the digitized signal, an identification number of the remote device, and a time stamp to the base device.

6. The method of claim 1, wherein the step of transmitting the signal to a monitoring device is performed periodically.

7. The method of claim 1, wherein step of the transmitting the electrical signal to a base device comprises:

transmitting the signal to the base device by at least one of a wireless application protocol link, a general packet radio service link, a Bluetooth radio link, an EEE 802.11-based radio frequency link, a RS-232 serial connection, an IEEE-1394 (Firewire) connection, a fibre channel connection, an infrared (IrDA) port, a small Computer Systems Interface (SCSI) connection, and a Universal Serial Bus (USB) connection.

8. The method of claim 1, further comprising the step of

periodically determining an amount of a drug to be injected in response to the analyte level; and

automatically providing the determined amount of the drug to the subject.

9. The method of claim 8, wherein the drug is insulin.

10. The method of claim 1, wherein the analyte level is displayed graphically.

11. The method of claim 10, wherein the analyte level is displayed in relative to time.

12. A system for real time remote monitoring of a level of at least one analyte in a body fluid, comprising:

a remote device, comprising:
a sensor that generates an electrical signal representative of the concentration of the at least one analyte; and
a transmitter that transmits the electrical signal;

a base device, comprising:
a receiver that receives the electrical signal;
a processor that processes the electrical signal; and
a display that displays the processed signal in real time.

13. The system of claim 12, wherein the at least one analyte is glucose.

14. The system of claim 12, wherein the remote device is affixed to the area of biological membrane with an adhesive.

15. The system of claim 12, wherein the transmitter transmits the electrical signal to a base device by at least one of a wireless application protocol link, a general packet radio service link, a Bluetooth radio link, an IEEE 802.11-based radio frequency link, a RS-232 serial connection, an IEEE-1394 (Firewire) connection, a fibre channel connection, an infrared (IrDA) port, a small Computer Systems Interface (SCSI) connection, and a Universal Serial Bus (USB) connection.

16. The system of claim 12, further comprising:

means for providing the subject with a drug.

17. The system of claim 16, wherein the processor determines an amount of the drug to provide the subject responsive to the analyte level.

18. The system of claim 17, wherein the drug is insulin.

19. The system of claim 12, wherein the display displays the analyte level graphically.

20. The system of claim 19, wherein the analyte level is displayed in relative to time.

21. A transdermal sensor, comprising:

a substrate having a first and a second surface;

a first electrode trace on the first surface of the substrate;

a second electrode trace on the second surface of the substrate;

a third electrode trace on the second surface of the substrate;
a fourth electrode trace on the second surface of the substrate;
a fifth electrode trace on the second surface of the substrate;
a dielectric on the second surface of the substrate; and
a plurality of electrical contacts.

22. The transdermal sensor of claim 21, wherein at least one of the first electrode trace and second electrode trace comprises silver.

23. The transdermal sensor of claim 21, wherein the third electrode trace comprises at least one of silver and silver chloride.

24. The transdermal sensor of claim 21, wherein the forth electrode trace comprises platinum.

25. The transdermal sensor of claim 21, wherein the fifth electrode trace comprises carbon.

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