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The present invention relates generally to the fields of immunology and molecular biology, and particularly to a method for treating hematopoietic disorders. The invention provides a method to treat a deficiency of one or more types of blood cells in a mammal, which includes administering an effective amount of TISF or of a compound that stimulates CD4+ cells like TISF does. In one embodiment, TISF that originates from a mammalian species is administered to a mammalian subject diagnosed as having a deficiency in one or more types of blood cells.

InventorsTerry Raymond Beardsley, Anthony E. Maida, III
Original AssigneeS-Cell Biosciences, Inc.
Primary Examiner: Robert A. Wax
Secondary Examiner: Marsha Tsay
Attorney: Morrison & Foerster LLP
Current U.S. Classification514/7.9; 514/13.5; 530/395; 530/397; 530/399

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Citations

Cited PatentFiling dateIssue dateOriginal AssigneeTitle
US5032396Jan 17, 1989Jul 16, 1991Immunex CorporationIL-7 to stimulate platelet production
US5616554Jul 26, 1994Apr 1, 1997Immune-enhancing agent for therapeutic use in immunocompromised hosts

Referenced by

Citing PatentFiling dateIssue dateOriginal AssigneeTitle
US8236323Feb 13, 2008Aug 7, 2012S-Cell Biosciences, Inc.Method to treat inflammation

Claims

1. A method to stimulate the production of red blood cells in a subject, wherein said subject has been diagnosed as having a less than desirable level of red blood cells, which method comprises administering to said subject an amount of T-4 immune stimulating factor (“TISF”) effective to elevate the red blood cell count.

2. The method of claim 1 wherein said less than desirable level of red blood cells is attributable to anemia.

3. A method to stimulate the production of granulocytes in a subject, wherein said subject has been diagnosed as having a less than desirable level of granulocytes, which method comprises administering to said subject an amount of TISF effective to elevate the granulocyte count.

4. A method to stimulate the production of platelets in a subject, wherein said subject has been diagnosed as having a less than desirable level of platelets, which method comprises administering to said subject an amount of TISF effective to elevate the platelet count.

5. A therapeutic protocol that comprises diagnosing a subject as having a less than desirable level of red blood cells, followed by administering to said subject an amount of TISF effective to elevate red blood cell count in said subject.

6. A therapeutic protocol that comprises diagnosing a subject as having a less than desirable level of granulocytes, followed by administering to said subject an amount of TISF effective to elevate granulocyte count in said subject.

7. A therapeutic protocol that comprises diagnosing a subject as having a less than desirable level of platelets, followed by administering to said subject an amount of TISF effective to elevate platelet count in said subject.