The invention provides extraction columns for the purification of an analyte (e.g., a biological macromolecule, such as a peptide, protein or nucleic acid) from a sample solution, as well as methods for making and using such columns. The columns typically include a bed of extraction media positioned...http://www.google.com/patents/US20050258097?utm_source=gb-gplus-sharePatent US20050258097 - Method and device for extracting an analyte