Pharmaceutical compositions of insulin drug-oligomer conjugates and methods ...

0 30 60 90 120 150 180 210 240

TIME (mm)

1 TIME (mm) VS. MEAN PLASMA INSULIN M/mL) - BASELINE (n-17)

2 TIME (min) VS. MEAN PLASMA INSULIN {jiU/mL) - 0.125 mgAg (n=40 fasted, n=32 fed)

3 TIME (min) VS. MEAN PLASMA INSULIN ((iU/mL) • 0.25 mgAg (n=40 fasted, n=32fed)

FIG. 5.