(i9) United States
(12) Patent Application Publication oo) Pub. No.: US 2007/0203552 Al
MACHOLD et al. (43) Pub. Date: Aug. 30,2007
(54) METHOD AND SYSTEM FOR CONTROL OF
A PATIENT'S BODY TEMPERATURE BY
WAY OF A TRANSLUMINALLY INSERTABLE
HEAT EXCHANGE CATHETER
(75) Inventors: TIMOTHY R. MACHOLD, MOSS
BEACH, CA (US); WADE A.
KELLER, SAN JOSE, CA (US);
ALEX T. ROTH, REDWOOD CITY,
CA (US); NICOLE DENISE BLOOM,
SAN FRANCISCO, CA (US)
FULWIDER PATTON LLP
HOWARD HUGHES CENTER
6060 CENTER DRIVE, TENTH FLOOR
LOS ANGELES, CA 90045 (US)
(73) Assignee: RADIANT MEDICAL, INC., REDWOOD CITY, CA (US)
(21) Appl. No.: 11/674,119
(22) Filed: Feb. 12, 2007
Related U.S. Application Data
(60) Continuation of application No. 10/645,891, filed on Aug. 20, 2003, now Pat. No. 7,175,649, which is a division of application No. 09/707,257, filed on Nov. 6, 2000, now Pat. No. 6,620,189, which is a continuation-in-part of application No. 09/563,946, filed on May 2, 2000, now Pat. No. 6,673,098.
(60) Provisional application No. 60/185,561, filed on Feb. 28, 2000.
Methods and apparatuses for temperature modification of a patient, or selected regions thereof, including an induced state of hypothermia. The temperature modification is accomplished using an in-dwelling heat exchange catheter within which a fluid heat exchange medium circulates. A heat exchange cassette of any one of several disclosed variations is attached to the circulatory conduits of the catheter, the heat exchange cassette being sized to engage a cavity within one of various described re-usable control units. The control units include a heater/cooler device, a user input device, and a processor connected to receive input from various sensors around the body and the system. The heater/cooler device may be thermoelectric to enable both heating and 15" cooling based on polarity. A temperature control scheme for ramping the body temperature up or down without overshoot is provided. The disposable heat exchange cassettes may include an integral pump head that engages with a pump drive mechanism within the re-usable control unit. More than one control unit may be provided to receive the same heat exchange cassette so that, for example, a large capacity control unit can be used initially, and a smaller, battery-powered unit can be substituted once the patient reaches the desired target temperature.