Fluorescent nanoparticle scope

US008062215B2

(12) United States Patent (10) Patent No.: US 8,062,215 B2 Voegele et al. (45) Date of Patent: Nov. 22, 2011 (54) FLUORESCENT NANOPARTICLE SCOPE 5,295,954 A 3/1994 Sachse 5,406,418 A * 4/1995 Deary ......................... .. 359/827 (75) Inventors: James W. Voegele, Cincinnati, OH (US); A * """""""""""" " 600/317 Robert M. Trusty, Cincinnati, OH (US) 536783555 A 10/1997 O.COnne11 5,701,903 A * 12/1997 S t l. .................. .. 600/478 (73) Assignee: Ethicon Endo-Surgery,Inc., Cincinnati, 5,749,830 A * 5/1998 Kinnlfoit 31, , 600/160 OH (US) 5,772,580 A * 6/1998 Utsuiet a1. .................. .. 600/160 5,861,027 A 1/1999 Trapp ( * ) Notice: Subject to any disclaimer, the term of this A g(;nt§lI:I)lt et a1‘ %atSeIg i1S5ZXgeILde‘111Zr32(‘ia‘1IuSted under 35 630133531 A 1/2000 Wa>I,1g et 41. ' ' ' ( ) y yS' (Continued) (21) Appl' No‘ 11/771’481 FOREIGN PATENT DOCUMENTS (22) Filed: Jun. 29, 2007 DE 102005041271 A1 3/2007 (Continued) (65) Prior Publication Data US 2008/0255414 A1 Oct. 16, 2008 OTHER PUBLICATIONS R l t d U S A l_ t_ D t “Quantum Dots Could Guide Surgeons”, NIBIB, Feb. 11, 2004. eae . . pp1ca1on aa (60) Provisional application No. 60/911,546, filed on Apr. (commued) 13’ 2007' Primary Examiner * John P Leubecker (51) Int Cl (74) Attorney, Agent, or Firm *Nutter McClennen & Fish A61B 1/00 (2006.01) LLP (52) U.S. Cl. ....................... .. 600/162; 600/181; 600/112 (57) ABSTRACT (58) Field of Classification Search ................ .. 600/162, _ _ _ _ _ 600/181’ 112’ 473 Various compos1t1ons, methods, and devices are provided See application file for Complete Search history that use fluorescent nanoparticles to function as markers, indicators, and light sources. In one embodiment, an endo(56) References Cited scopic adaptor is provided for vieWing fluorescent nanopar

U.S. PATENT DOCUMENTS

ticles. The adaptor can be configured to removably mate to a portion of an endoscope, such as an eyepiece, and it can be adapted to contain a filter for filtering light received through the vieWing lumen of the eyepiece. In an exemplary embodiment, the filter is configured to transmit fluorescent light While blocking visible light, to thereby enable a structure containing one or more fluorescent nanoparticles to be vieWed through the endoscope.

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