(12) United States Patent ao) Patent No.: us 6,288,127 Bi
Bieniarz et al. (45) Date of Patent: *Sep. 11,2001
(54) FLUOROETHER COMPOSITIONS AND
METHODS FOR INHIBITING THEIR
DEGRADATION IN THE PRESENCE OF A
(75) Inventors: Christopher Bieniarz, Highland Park;
Steve H. Chang, Gurnee; Keith R.
Cromack, Lake Bluff; Shuyen L.
Huang, Riverwoods, all of IL (US);
Toshikazu Kawai; Manami
Kobayashi, both of Saitama (JP);
David Loffredo, Elmhurst, IL (US);
Rajagopalan Raghavan, Grayslake, IL
(US); Earl R. Speicher, Buffalo Grove,
IL (US); Honorate A. Stelmach, Lake
Forest, IL (US)
(73) Assignee: Abbott Laboratories & Central Glass Co LTD, Abbott Park, IL (US)
( * ) Notice: This patent issued on a continued prosecution application filed under 37 CFR 1.53(d), and is subject to the twenty year patent term provisions of 35 U.S.C. 154(a)(2).
Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days.
This patent is subject to a terminal disclaimer.
(21) Appl. No.: 09/447,853
(22) Filed: Nov. 23, 1999
Related U.S. Application Data
(63) Continuation of application No. 08/789,679, filed on Jan. 27, 1997, now Pat. No. 5,990,176.
(51) Int. CI.7 A61K 31/08; C07C 43/12
(52) U.S. CI 514/722; 568/683; 568/684;
(58) Field of Search 514/722, 816;
(56) References Cited
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Primary Examiner—Charanjit S. Aulakh
(74) Attorney, Agent, or Firm—Brian R. Woodworth
The present invention relates to an anesthetic composition containing a fiuoroether compound and a physiologically acceptable Lewis acid inhibitor. This composition exhibits improved stability and does not readily degrade in the presence of a Lewis acid.