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(12) United States Patent ao) Patent No.: us 6,308,094 Bi
Shusterman et al. (45) Date of Patent: *Oct. 23,2001
(54) SYSTEM FOR PREDICTION OF CARDIAC ARRHYTHMIAS
(75) Inventors: Vladimir Shusterman; Benhur Aysin;
Han Grave, all of Pittsburgh; Luis F.
Chaparro, Monroeville; Kelley P.
Anderson, Sewickley, all of PA (US)
(73) Assignee: University of Pittsburgh of the
Commonwealth System of Higher
Education, Pittsburgh, PA (US)
( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days.
This patent is subject to a terminal disclaimer.
(21) Appl. No.: 09/376,027
(22) Filed: Aug. 17, 1999
Related U.S. Application Data
(63) Continuation-in-part of application No. 09/067,586, filed on Apr. 28, 1998, now Pat. No. 5,967,995.
(51) Int. CI.7 A61N 5/0468
(52) U.S. C I 600 516
(58) Field of Search 600/515-518
(56) References Cited
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A medical device and method for predicting cardiac arrhythmias, by gathering electrocardiographic data such as intervals between heart beats (RR-series) or other signal, mathematically decomposing or compressing the signal into several elements or components that contain the most significant information and tracking the changes in the several elements. The signal may be divided into time windows, and the signals decomposed into a plurality of coefficients or components such as Karhunen Loeve Transformation (KLT) coefficients that are predictive of the occurrence of a cardiac arrhythmia. The electrocardiographic data may be generated real-time, on-line, or be prerecorded data.
25 Claims, 14 Drawing Sheets
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