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United States Patent [w]

Cespedes et al.

US006165128A [ii] Patent Number: [45] Date of Patent:

6,165,128 Dec. 26,2000

[54] METHOD AND APPARATUS FOR MAKING AN IMAGE OF A LUMEN OR OTHER BODY CAVITY AND ITS SURROUNDING TISSUE

[75] Inventors: E. I. Cespedes, Folsom, Calif.; C. L.

de Korte, Driebergen-Rijsenburg; A. F. W. van der Steen, Rotterdam, both of Netherlands

[73] Assignee: EndoSonics Corporation, Rancho Cordova, Calif.

[21] Appl. No.: 09/166,016

[22] Filed: Oct. 5, 1998

[30] Foreign Application Priority Data

Oct. 6, 1997 [EP] European Pat. Off 97203072

[51] Int. CI. A61B 8/12

[52] U.S. CI 600/463

[58] Field of Search 600/437, 443,

600/449, 455-456; 128/916

[56] References Cited

U.S. PATENT DOCUMENTS 5,125,410 6/1992 Misono et al. .

5,195,521 3/1993 Melton, Jr. et al 600/456

5,622,174 4/1997 Yamazobi 600/455 X

5,800,356 9/1998 Criton et al 600/455 X

FOREIGN PATENT DOCUMENTS

WO 94/23652 10/1994 WIPO .

OTHER PUBLICATIONS

C. L. de Korte et al., "Intravascular Elasticity Imaging Using Ultrasound: Feasibility Studies In Phantoms," Ultrasound in Medicine and Biology, vol. 23, No. 5, May 1997, USA, pp. 735-746.

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Method and apparatus for making an image of a lumen and surrounding tissue in a body by inserting a transducer in the cavity and emitting ultrasound signals and collecting and processing echo signals to form an image, where the apparatus includes a signal processor arranged for performing the steps of and the method includes the steps of:

a) obtaining echo signals from tissue at a given state of mechanical stress in a chosen direction;

b) obtaining similar echo signals after a change of the mechanical stress;

c) identifying the lumen-tissue boundary;

d) comparing the echo signals to obtain a parameter indicative of tissue stiffness;

e) performing similar steps for a number of directions;

f) deriving and displaying the conventional echo image of the lumen and surrounding tissue from the echo signals of step a);

g) superimposing in said image the tissue stiffness as a coded line along the lumen-tissue boundary.

13 Claims, 6 Drawing Sheets

(6 of 6 Drawing Sheet(s) Filed in Color)

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SOFT PLAQUE PHANTOM

Strain [%] 20

1 0

Figure 3

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