(12) United States Patent ao) Patent No.: us 6,530,900 Bi
Daily et al. (45) Date of Patent: Mar. 11,2003
(54) DRUG DELIVERY DEVICE
(75) Inventors: David Daily, Herzliya (IL); Oz Cabiri, Macabim (IL); Mario Rozanowich, Ezer (IL); Miki Sahar, Ramat Hasharon (IL); Jacob Stern, Shoam (IL); Diana Davidson, Framingham, MA (US); Izrail Tsals, Sudbury, MA (US); Gilad Lavi, Holon (IL); Avi Azoulay, Ashdod (IL); Eran Shor, Moshav Bitzaron (IL); Craig Brodeur, Marlborough, MA (US)
(73) Assignee: Elan Pharma International Limited,
( * ) Notice: Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days.
(21) Appl. No.: 09/577,033
(22) Filed: May 23, 2000
Related U.S. Application Data
(63) Continuation-in-part of application No. 09/072,875, filed on May 5, 1998.
(60) Provisional application No. 60/045,745, filed on May 6, 1997.
(51) Int. CI.7 A61M 37/00
(52) U.S. CI 604/132; 604/891.1; 604/141
(58) Field of Search 604/132, 141,
604/148, 145, 146, 246-249, 167.01-167.05, 19, 48, 65, 93.01, 131, 133, 140, 173, 174, 180, 890.1, 891.1
(56) References Cited
U.S. PATENT DOCUMENTS 4,684,367 A 8/1987 Schaffer et al.
A drug delivery device having a housing having an internal reservoir in communication with a drug delivery outlet via a fluid path. An expandable chamber disposed adjacent to the reservoir forces drug from the reservoir to the outlet when supplied with a gas. A flow regulating chamber, in communication with the fluid path, is capable of volumetric changes in response to temperature and/or pressure changes. An increase in the volume of the flow regulating chamber increases flow resistance to the outlet and thereby counteracts the corresponding increase in delivery rate resulting from the expansion of the expandable chamber due to the same volumetric changes in response to temperature and/or pressure. In a preferred embodiment, an electrical circuit has a current stabilizing element in electrical communication with an electrolytic cell which supplies the gas. A throttling device maintains a higher pressure in the device to reduce possible clogging of the fluid path. In a preferred embodiment, the drug delivery device is packaged to insulate the device from atmospheric pressure and humidity.
11 Claims, 48 Drawing Sheets