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(12) United States Patent ao) Patent No.: us 6,675,048 B2
McGraw et al. (45) Date of Patent: Jan. 6,2004
(54) ELECTRO-MEDICAL DEVICE FOR USE WITH BIOLOGICS
(75) Inventors: Michael B. McGraw, Vancouver, WA (US); William A. Rux, Hillsboro, OR (US); William J. Carroll, Sedro Woolley, WA (US); Richard M. Terrell, Vancouver, WA (US); Randy Alan Murphy, Vancouver, WA (US)
(73) Assignee: International Rehabilitative Sciences, Inc., Vancouver, WA (US)
( * ) Notice: Subject to any disclaimer, the term ol this patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days.
(21) Appl. No.: 09/905,159
(22) Filed: Jul. 16, 2001
(65) Prior Publication Data
US 2002/0016616 Al Feb. 7, 2002
Related U.S. Application Data
(63) Continuation-in-part ol application No. 09/679,557, filed on Oct. 6, 2000, which is a continuation-in-part ol application No. 09/566,081, filed on May 8, 2000.
(51) Int. C I. A61N 1/18
(52) U.S. CI 607/51; 607/3
(58) Field of Search 607/3, 50, 51,
607/66, 67, 75, 76
(56) References Cited
U.S. PATENT DOCUMENTS
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(List continued on next page.)
Primary Examiner—Scott M. Getzow
(74) Attorney, Agent, or Firm—Blank Rome LLP
A multi-functional portable electro-medical device provides interferential current stimulation to promote bone growth. Two electrical signals are applied to a target area, each electrical signal being formed by a set of two electrode pads. A beat frequency is created at the location the signals intersect with each other. The beat frequency is the difference between the frequencies of the two signals and has an amplitude that is additive and greater than either signal alone. The depth of the interferential signal is increased by increasing the carrier frequency of the signals. The direction of the interferential signal shifts toward the signal having the lower amplitude. The electrical stimulation is used in combination with biologies to further increase bone growth. The target area is large enough to include multiple vertebral segments.
23 Claims, 58 Drawing Sheets
Posterolateral Lumbar Intertransverse Process Spine Arthrodesis with Recombinant Human Bone Morphogenetic Protein 2/hyroxyapatite-tricalcium Phosphate after Laminectomy in the Nonhuman Primate, S.D. Boden et al., Spine, Jun. 15, 1999, vol. 24, No. 12; pp. 1179-1185 (abstract only).
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* cited by examiner