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US006527759B1

(12) United States Patent ao) Patent No.: us 6,527,759 Bi

Tachibana et al. (45) Date of Patent: Mar. 4,2003 Page 2

(54) ULTRASOUND ASSEMBLY FOR USE WITH LIGHT ACTIVATED DRUGS

(75) Inventors: Katsuro Tachibana, Fukuoka (JP);

Shunro Tachibana, Fukuoka (JP);
James R. Anderson, Redmond, WA
(US); Gary Lichttenegger,

Woodinville, WA (US)

(73) Assignee: Ekos Corporation, Bothell, WA (US)

( * ) Notice: Subject to any disclaimer, the term ol this patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days.

(21) Appl. No.: 09/620,701

(22) Filed: Jul. 20, 2000

Related U.S. Application Data

(62) Division of application No. 09/158,316, filed on Sep. 21, 1998, now Pat. No. 6,176,842, which is a continuation-inpart of application No. 09/129,980, filed on Aug. 5, 1998, now Pat. No. 6,210,356, which is a continuation-in-part of application No. 08/972,846, filed on Nov. 18, 1997, now abandoned, which is a continuation of application No. 08/611,105, filed on Mar. 5, 1996, now abandoned.

(30) Foreign Application Priority Data

Mar. 5, 1995 (JP) P7-048710

Sep. 19, 1997 (JP) 9-70617

(51) Int. CI.7 A61M 31/00

(52) U.S. CI 604/500; 604/509; 604/522;

604/22

(58) Field of Search 604/21-22, 500,

604/101.01, 101.03, 507-509, 522; 607/97;

601/2, 3; 514/410, 145

(56) References Cited

U.S. PATENT DOCUMENTS

3,433,226 A 3/1969 Boyd 128/305

4,027,659 A 6/1977 Slingluff 128/2 M

4,040,414 A 8/1977 Suroff 128/24

4,319,580 A 3/1982 Colley et al 128/661

4,354,502 A 10/1982 Colley et al 128/663

4,512,762 A 4/1985 Spears 604/21

4,531,943 A 7/1985 Van Tassel et al 604/280

4,582,067 A 4/1986 Silverstein et al.

4,750,902 A 6/1988 Wuchinich et al 604/22

4,767,402 A 8/1988 Kost et al 604/49

4,780,212 A 10/1988 Kost et al 210/646

4,808,153 A 2/1989 Parisi 604/22

4,870,953 A 10/1989 Don Michael et al 128/24

(List continued on next page.)

FOREIGN PATENT DOCUMENTS

DE 39 19 592 Al 2/1990 A61B/17/22

DE 40 05 743 8/1991 A61H/23/00

EP 0 529 675 8/1992 A61B/17/06

(List continued on next page.)

OTHER PUBLICATIONS

Hynynen et al.; "Small Cylindrical Ultrasound Sources For Induction ol Hyperthermia Via Body Cavities or Interstitial Implants"; Arizona Cancer Center and Department of Radiation Oncology, University of Arizona Health Sciences Center; vol. 9, No. 2; pp. 263-274; 1993.

(List continued on next page.)

Primary Examiner—Mark Bockelman

(74) Attorney, Agent, or Firm—Knobbe, Martens, Olson &

Bear, LLP

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U.S. PATENT DOCUMENTS

[table]

Conway et al 128/344

Crittendon 606/194

Miller et al 128/772

Alliger et al 128/24

Sterzer 606/27

Stasz 128/660.03

Walker et al 604/165

Umemura et al 514/410

Bonnett et al 424/9

Sharawy 604/53

Unger 604/22

Umemura et al 128/24

Bernstein et al 128/24.1

Ishihara 424/489

Tachibana 604/22

Appling et al 604/164

Nita 604/22

Shimada et al 604/290

Carter 128/24

Shapland et al 604/21

Shapland et al 604/21

Marcus et al 128/660.03

Pflueger et al 604/22

Carter 601/2

Bommannan et al 601/2

Rammler 128/658

Nabel et al 604/101

Turner et al 607/101

Seward et al 128/662.06

Sieben 128/662.06

Hofling 604/164

Carter 604/22

Lieber 128/662.06

Tanaka et al.

Dubrul et al 604/22

Gesswein et al 128/662.06

Crowley et al 128/662.06

Sorin et al 606/1

Carter 604/128

Sieben 128/660.07

Mills et al 606/1

Racchini et al 604/19

Dickinson et al 128/663.01

Passafaro et al 604/22

Carter 604/22

Meserol 604/20

Shapland et al 604/53

Carter 604/21

Forman et al 604/101

Malinowski et al. .. 128/662.03

Magda et al 514/44

Sessler et al 540/472

Sessler et al 540/145

Eberle 128/662.06

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