(19) United States
(12) Patent Application Publication (io) Pub. No.: US 2004/0049265 Al
Ding et al. (43) Pub. Date: Mar. 11,2004
(54) DRUG COATING WITH TOPCOAT
(75) Inventors: Ni Ding, Plymouth, MN (US); Michael N. Helmus, Long Beach, CA (US)
PENNIE AND EDMONDS
1155 AVENUE OF THE AMERICAS
NEW YORK, NY 100362711
(73) Assignee: Schneider (USA) Inc.
(21) Appl. No.: 10/603,115
(22) Filed: Jun. 24, 2003
Related U.S. Application Data
(60) Continuation ol application No. 09/942,716, filed on Aug. 30, 2001, now Pat. No. 6,620,194, which is a continuation ol application No. 09/573,506, filed on May 18, 2000, now Pat. No. 6,284,305, which is a division ol application No. 08/996,410, filed on Dec. 22, 1997, now Pat. No. 6,099,562, which is a continuation-in-part ol application No. 08/663,518, filed
on Jun. 13, 1996, now Pat. No. 6,120,536, which is a continuation-in-part ol application No. 08/526,273, filed on Sep. 11, 1995, now abandoned, which is a continuation-in-part ol application No. 08/424,884, filed on Apr. 19, 1995, now abandoned.
(51) Int. CI.7 A611- 2/06
(52) U.S. CI 623/1.42
A coating and method for a coating an implantable device or prostheses are disclosed. The coating includes an undercoat ol polymeric material containing an amount ol biologically active material, particularly heparin, dispersed therein. The coating further includes a topcoat which covers less than the entire surface of the undercoat and wherein the topcoat comprises a polymeric material substantially free of pores and porosigens. The polymeric material of the topcoat can be a biostable, biocompatible material which provides long term non-thrombogenicity to the device portion during and after release of the biologically active material.