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FOREIGN PATENT DOCUMENTS
WO WO 97/09620 * 3/1997
Akintoye et al. (Archives of Oral Biology, vol. 47, 2002, pp. 337345).*
(Continued) Primary Examiner—Lisa V Cook
(74) Attorney, Agent, or Firm—Virtual Law Partners, LLP; Richard G. A. Bone
Provided are methods, test devices, and diagnostic kits for predicting, assessing, and diagnosing the risk of a disease using salivary analysis. The methods comprise providing a whole (unfractionated) saliva sample from a subject; contacting an aliquot of the saliva with two or more lectins under conditions that allow the two or more lectins to bind to a lectin-binding component of the saliva; detecting the amount of bound lectin; and comparing the amount of bound lectin to the amount known to bind a saliva sample from a control patient, to predict the risk of a disease in the subject. Also provided are methods for reducing the risk of a disease and a method for assessing the risk of the disease at a defined level.
36 Claims, 18 Drawing Sheets
U.S. PATENT DOCUMENTS
2002/0177171 Al 11/2002 Stromberg 2003/0040009 Al 2/2003 Denny et al.
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* cited by examiner