L-arginine and phosphodiesterase (PDE) inhibitor synergism

(75) Inventor: Arthur W. Wallace, San Rafael, CA (U5) (73) Assignee: The Regents 0f the University of California, Oakland, CA (US) ( * ) N050??? Subject to any disclaimer, the term of this patent is extended or adjusted under 35 U.S.C. 154(b) by 0 days. (21) Appl. No.: 09/644,982 (22) Filed: Mar. 23, 2000 (51) Int. Cl.7 .............................................. .. A01N 43/54 (52) U.S. Cl. ..................... .. 514/258; 514/262; 514/253; 514/565 (58) Field of Search ............................... .. 514/505, 262, 514/253, 258 (56) References Cited U.S. PATENT DOCUMENTS 5,767,160 A * 6/1998 Kaesemeyer .............. .. 514/565 5,891,459 A * 4/1999 Cooke et al. ............. .. 424/439 5,919,474 A 7/1999 Place et al. 5,958,926 A * 9/1999 Gan/ey et al. ............ .. 514/253 6,071,272 A * 6/2000 Hoffman et al. .......... .. 604/500 6,127,363 A 10/2000 Doherty, Jr. et al. 6,156,753 A 12/2000 Doherty, Jr. et al. 6,207,713 B1 * 3/2001 Fossel ...................... .. 514/565 6,277,884 B1 * 8/2001 de Tejada 515/565 6,284,763 B1 * 9/2001 Adams et al. ....... .. 514/211.07 6,300,335 B1 10/2001 Campbell et al. 2002/0035067 A1 * 3/2002 Adams et al. .............. .. 514/18

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