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The present invention relates to a contraceptive for use by a male. The contraceptive consists of a copolymer of styrene maleic anhydride which is prepared by the step of irradiation at a dose of 0.2 to 0.24 megarad for every 40 gms. of the copolymer. The contraceptive consists of an injectable fluid of said copolymer and pure dimethyl sulphoxide.

Inventor: Sujoy K. Guha
Current U.S. Classification: 522/168; 424/78.2; 424/78.21; 424/78.26; 424/78.33; 424/DIG.14; 514/708; 514/772.6; 514/841; 522/79
International Classification: C08L 2508; C08K 541; A61K 3174

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Citations

Cited PatentFiling dateIssue dateOriginal AssigneeTitle
US2384085Apr 3, 1941Sep 4, 1945PROCESS OF FORMING A CLEAR PLAS
US2955994Dec 16, 1954Oct 11, 1960RADIOCHEMICAL PREPARATION OF ION-EX-
US3398226Nov 10, 1966Aug 20, 1968COMPLEX OF THIAMINE AND A STYRENE-MALEIC ANHYDRIDE COPOLYMER
US3616229Sep 27, 1968Oct 26, 1971TABLE VII
US4432967Jun 25, 1982Feb 21, 1984National Starch and Chemical Corp.Contraceptive composition
US4439441Jul 19, 1982Mar 27, 1984SYNTEX (U.S.A.) Inc.Contraceptive compositions and methods employing 1-substituted imidazole derivatives
US4760097Oct 1, 1985Jul 26, 1988The University of Western OntarioBiological contraceptive for males
US4917901May 22, 1987Apr 17, 1990Atlantic Pharmaceutical Products, Ltd.Methods and compositions for inhibiting or destroying spermatozoa and organisms which causes sexually transmitted diseases in mammalian host

Referenced by

Citing PatentFiling dateIssue dateOriginal AssigneeTitle
US5989580Dec 11, 1996Nov 23, 1999Micro Therapeutics, Inc.Methods for sterilizing female mammals
US6103254Feb 19, 1997Aug 15, 2000Micro Therapeutics, Inc.Methods for sterilizing male mammals

Claims

1. A contraceptive for use by a male comprising an injectable fluid of a copolymer of styrene with maleic anhydride in a solvent consisting of dimethylsulphoxide characterized in that said copolymer is prepared by subjecting a mixture of styrene and maleic anhydride to the step of irradiation at a dose of 0.2 to 0.24 megarad for every 40 gms. of said mixture.

2. A contraceptive as claimed in claim 1 wherein said mixture of styrene and maleic anhydride is irradiated at a dose rate of 30 to 40 rads/sec.

3. A contraceptive as claimed in claim 1 wherein said copolymer has a molecular weight of 60,000 to 100,000.

4. A contraceptive as claimed in claims 1 to 3 wherein the viscosity is 1.2 to 2.0 relative to dimethylsulphoxide.

5. A contraceptive as claimed in claim 1 wherein said copolymer has styrene and maleic anhydride present in the ratio of 1.2:1 and preferably 1:1.

6. A contraceptive as claimed in claim 1 wherein the injected copolymer solution has a pH of 4.0 to 4.5.

7. A contraceptive as claimed in claim 1 wherein said copolymer has styrene and maleic anhydride present in the ratio of 1:1.

Drawings