Search Images Maps Play YouTube News Gmail Drive More »
Advanced Patent Search | Web History | Sign in

Patents

A retroviral protease inhibiting compound of the formula: ##STR1## is disclosed.

InventorsDale J. Kempf, Daniel W. Norbeck, Hing Leung Sham, Chen Zhao
Original AssigneeAbbott Laboratories
Current U.S. Classification514/365; 514/374
International Classification: A61K 3141

View patent at USPTO
Search USPTO Assignment Database

Citations

Cited PatentFiling dateIssue dateOriginal AssigneeTitle
US4172094Dec 3, 1976Oct 23, 1979Merck & Co., Inc.Polyamine compounds
US4618619Mar 14, 1984Oct 21, 1986Bayer AktiengesellschaftSubstituted t-butanol fungicidal agents
US4644055Dec 17, 1984Feb 17, 1987E. I. Du Pont de Nemours and CompanyMethod for preparing specific inhibitors of virus-specified proteases
US4652552Sep 10, 1984Mar 24, 1987E. I. Du Pont de Nemours and CompanyTetrapeptide methyl ketone inhibitors of viral proteases
US5142056May 9, 1990Aug 25, 1992Abbott LaboratoriesRetroviral protease inhibiting compounds
US5354866Sep 14, 1993Oct 11, 1994Abbott LaboratoriesRetroviral protease inhibiting compounds

Referenced by

Citing PatentFiling dateIssue dateOriginal AssigneeTitle
US5886036Mar 20, 1997Mar 23, 1999Abbott LaboratoriesRetroviral protease inhibiting compounds
US6017928Oct 6, 1997Jan 25, 2000Abbott LaboratoriesRetroviral protease inhibiting compounds
US6037157Jun 26, 1996Mar 14, 2000Abbott LaboratoriesMethod for improving pharmacokinetics
US6284767Dec 8, 1998Sep 4, 2001Abbott LaboratoriesRetroviral protease inhibiting compounds
US6472529Apr 18, 2001Oct 29, 2002Abbott LaboratoriesRetroviral protease inhibiting compounds
US6703403Sep 20, 2001Mar 9, 2004Abbott LaboratoriesMethod for improving pharmacokinetics
US7148359May 4, 2005Dec 12, 2006Abbott LaboratoriesPolymorph of a pharmaceutical
US7183416Jul 29, 2004Feb 27, 2007Abbott LaboratoriesPolymorph of a pharmaceutical
US7279582Oct 25, 2002Oct 9, 2007Abbott LaboratoriesRetroviral protease inhibiting compounds
US7659405Sep 21, 2006Feb 9, 2010Abbott LaboratoriesPolymorph of a pharmaceutical
US7939553Jul 6, 2007May 10, 2011Gilead Sciences, Inc.Modulators of pharmacokinetic properties of therapeutics
US7968707Feb 27, 2007Jun 28, 2011Abbott LaboratoriesRetroviral protease inhibiting compounds
US8025899Aug 25, 2004Sep 27, 2011Abbott LaboratoriesSolid pharmaceutical dosage form
US8067449Jul 6, 2007Nov 29, 2011Gilead Sciences, Inc.Modulators of pharmacokinetic properties of therapeutics
US8088770Jul 3, 2008Jan 3, 2012Gilead Sciences, Inc.Modulators of pharmacokinetic properties of therapeutics
US8148374Feb 22, 2008Apr 3, 2012Gilead Sciences, Inc.Modulators of pharmacokinetic properties of therapeutics
US8193367Dec 22, 2009Jun 5, 2012Abbott LaboratoriesPolymorph of a pharmaceutical
USRE42889Apr 23, 2007Nov 1, 2011G.D. Searle LLCα- and β- amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors

Claims

1. A method for inhibiting an HIV infection comprising administering to a human in need thereof a therapeutically effective amount of (2S,3S,5S)-5-(N-(N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)-amino)carbonyl)valinyl)amino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane or a pharmaceutically acceptable salt thereof in combination with a therapeutically effective amount of another HIV protease inhibiting compound.

2. The method of claim 1 wherein the other HIV inhibiting is selected from the group of Ro 31-8959 SC-52151 KNI-227 and KNI-272.

3. A method for inhibiting an HIV infection comprising administering to a human in need thereof a therapeutically effective amount of (2S,3S,5S)-5-(N-(N-((N-Methyl-N-((2-isopropyl-4-thiazolyl)methyl)-amino)carbonyl)valinyl)amino)-2-(N-((5-thiazolyl)methoxycarbonyl)amino)-1,6-diphenyl-3-hydroxyhexane or a pharmaceutically acceptable salt thereof in combination with a therapeutically effective amount of Ro 31-8959.