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A stable aqueous solution having high concentrations of both biologically available calcium and biologically available phosphate is provided by combining phosphate and calcium ions in the aqueous solution wherein the phosphate is in the form of a saccharide phosphate and preferably a monosaccharide diphosphate. Preferred solutions include fructose 1,6-diphosphate, glucose diphosphate, sucrose diphosphate and so on. This is particularly suitable for providing calcium and phosphate ions in a total parenteral nutrition solution.

Inventor: Edward A. Deutsch
Original Assignee: University of Cincinnati
Current U.S. Classification: 514/53; 424/1.65; 424/9.35; 424/439; 424/499; 426/72; 426/648; 514/1; 514/23; 514/54; 536/127
International Classification: A01N 4304; A01N 5700; A23L 130

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Citations

Cited PatentFiling dateIssue dateOriginal AssigneeTitle
US2541568Dec 18, 1947Feb 13, 1951NONCUBDING HIGH CALCIUM MILK PROD
US3962484Jun 3, 1974Jun 8, 1976The Dow Chemical CompanyMethod for preparing liquid feed supplements containing calcium chloride
US4058601Jul 1, 1975Nov 15, 1977Chugai Seiyaku Kabushiki KaishaMethod for treating alcoholism
US4263052Oct 12, 1979Apr 21, 1981American Crystal Sugar CompanyProduction of fructose and useful by-products
US4414238Dec 24, 1981Nov 8, 1983Cutter Laboratories, Inc.Liquid elemental diet
US4497800Jul 6, 1982Feb 5, 1985Mead Johnson & CompanyStable liquid diet composition
US4546095Sep 3, 1982Oct 8, 1985Use of fructose-1,6-diphosphate for treating myocardial infarction
US4787940Feb 9, 1987Nov 29, 1988Kao CorporationMethod for purifying sugar phosphates or their salts

Referenced by

Citing PatentFiling dateIssue dateOriginal AssigneeTitle
US7932326Apr 16, 2008Apr 26, 2011The University of Kentucky Research FoundationChelating compounds and immobilized tethered chelators
US8066883Mar 21, 2011Nov 29, 2011University of Kentucky Research FoundationRemoving aluminum from solution using chelating compounds and immobilized tethered chelators

Claims

1. A total parenteral nutrition diet consisting essentially of an aqueous solution having a concentration of at least 10 mM up to 1000 mM of calcium ions and at least 10 mM up to 1000 mM of phosphate ions wherein said phosphate ions are saccharide phosphate ions and wherein said saccharide phosphate ions are selected from the group consisting of fructose diphosphate, sucrose diphosphate, glucose diphosphate, fructose phosphate, sucrose phosphate and glucose phosphate and amino acids, saccharides and nutrients effective to provide the total nutritional diet for a patient.

2. The total parenteral nutrition diet claimed in claim 1 wherein said monosaccharide diphosphate ions are fructose diphosphate ions.

3. The total parenteral nutrition diet claimed in claim 1 wherein said monosaccharide diphosphate ions are glucose diphosphate ions.

4. The total parenteral nutrition diet claimed in claim 1 wherein said saccharide phosphate ions are sucrose diphosphate ions.

5. The total parenteral nutrition diet claimed in claim 1 wherein said concentration of calcium ions is from 10 to about 100 mM and said concentration of phosphate ions is 10 to 100 mM of biologically available phosphate ions.

6. The total parenteral nutrition diet claimed in claim 3 wherein said concentration of calcium ions is from 10 to about 50 mM and the concentration of biologically available phosphate ions is from 10 to about 50 mM.

7. An aqueous solution selected from the group consisting of fruit juice and electrolyte replacement drinks, said solution having at least 10 mM to 1000 mM calcium ions in solution and a concentration of at least 10 mM to 1000 mM phosphate ions in solution, said phosphate ions present in the form selected from the group consisting of fructose diphosphate, sucrose diphosphate, glucose diphosphate, fructose phosphate, sucrose phosphate and glucose phosphate.

8. The total parenteral nutrition diet claimed in claim 1 wherein said aqueous solution is subsequently lyophilized.

9. The total parenteral nutrition diet claimed in claim 2 wherein said aqueous solution is subsequently lyophilized.

10. The total parenteral nutrition diet claimed in claim 3 wherein said aqueous solution is subsequently lyophilized.

11. The total parenteral nutrition diet claimed in claim 4 wherein said aqueous solution is subsequently lyophilized.

12. The total parenteral nutrition diet claimed in claim 5 wherein said aqueous solution is subsequently lyophilized.

13. The total parenteral nutrition diet claimed in claim 6 wherein said aqueous solution is subsequently lyophilized.