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P-glycoproteins and uses thereof

 Sara Hanscom et al
The invention pertains to rhesus monkey P-glycoproteins and related P-glycoproteins which include rhesus-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the rhesus monkey P-glycop...
Inventors: Sara Hanscom, Charles Crespi
Assignees: Becton, Dickinson and Company
Primary Examiner: Jon Weber
Secondary Examiner: Sheridan Snedden
Attorneys: Wolf, Greenfield & Sacks, P.C.

U.S. Classification
530/395

International Classification
C07K001/00

View patent at USPTO

Citations

Patent NumberTitleIssue date
5429921Assays for agonists and antagonists of recombinant human calcium channelsJul 4, 1995
5641508Method for delivering melanin to hair folliclesJun 24, 1997
5830697P-glycoprotein mutant resistant to cyclosporin modulationNov 3, 1998
6617450P-glycoproteins and uses thereofSep 9, 2003
6753177P-glycoproteins and uses thereofJun 22, 2004

Claims

What is claimed is:

1. An isolated nucleic acid molecule that encodes the amino acid sequence of SEO ID NO:2 and complements thereof.

2. An isolated nucleic acid molecule that encodes the amino acid seuuence of SEO ID NO:2, wherein the isolated nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO: 1.

3. An expression vector comprising the isolated nucleic acid molecule of claim 1 operably linked to a promoter.

4. An expression vector comprising the isolated nucleic acid molecule of claim 2 operably linked to a promoter.

5. A host cell transformed or transfected with the expression vector of claim 3.

6. A host cell transformed or transfected with the expression vector of claim 4.