ENSMUSG00000026241


Mus musculus

Features
Gene ID: ENSMUSG00000026241
  
Biological name :Nppc
  
Synonyms : natriuretic peptide type C / Nppc / Q61839
  
Possible biological names infered from orthology : natriuretic peptide C / P23582
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C5
Gene start: 86666291
Gene end: 86670571
  
Corresponding Affymetrix probe sets: 10356345 (MoGene1.0st)   1422790_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027449
NCBI entrez gene - 18159     See in Manteia.
MGI - MGI:97369
RefSeq - NM_010933
RefSeq Peptide - NP_035063
swissprot - Q544K5
swissprot - Q61839
Ensembl - ENSMUSG00000026241
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nppcENSDARG00000068126Danio rerio
 NPPCENSG00000163273Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000663  Natriuretic peptide
 IPR002406  Natriuretic peptide, C type
 IPR030480  Natriuretic peptide, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0003418 growth plate cartilage chondrocyte differentiation IMP
 biological_processGO:0003419 growth plate cartilage chondrocyte proliferation IMP
 biological_processGO:0006182 cGMP biosynthetic process IEA
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0007168 receptor guanylyl cyclase signaling pathway IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0022414 reproductive process IMP
 biological_processGO:0030814 obsolete regulation of cAMP metabolic process IEA
 biological_processGO:0030823 obsolete regulation of cGMP metabolic process IEA
 biological_processGO:0030828 obsolete positive regulation of cGMP biosynthetic process IEA
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0048513 animal organ development IMP
 biological_processGO:0048660 regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050880 regulation of blood vessel size IEA
 biological_processGO:0051053 negative regulation of DNA metabolic process IEA
 biological_processGO:0051447 negative regulation of meiotic cell cycle ISO
 biological_processGO:0097755 positive regulation of blood vessel diameter IEA
 biological_processGO:1900194 negative regulation of oocyte maturation ISO
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005184 neuropeptide hormone activity TAS
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0051427 hormone receptor binding IEA
 molecular_functionGO:0051428 peptide hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
Physiological factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apbb1tm1Quhu/Apbb1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Nppclbab/Nppclbab
Genetic Background: B6.PL-Nppclbab/GrsrJ

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

 MP:0000968 abnormal sensory neuron innervation "defective or incomplete supply of nerve fibers to sensory termini or to spinal cord" [J:31622]
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Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Nppclbab/Nppclbab
Genetic Background: involves: PL/J

Allelic Composition: Nppctm1.1Fgr/Nppctm1.1Fgr,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * CBA

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Nppctm1Yog/Nppctm1Yog
Genetic Background: either: (129X1/SvJ) or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Nppclbab/Nppclbab
Genetic Background: B6.PL-Nppclbab/GrsrJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Nppctm1Yog/Nppctm1Yog
Genetic Background: either: (129X1/SvJ) or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Nppclbab/Nppclbab
Genetic Background: B6.PL-Nppclbab/GrsrJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nppctm1Yog/Nppctm1Yog
Genetic Background: either: (129X1/SvJ) or (involves: 129/Sv * C57BL/6J)

 MP:0002427 dwarfism "abnormally undersized with disproportionate body parts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Nppctm1Yog/Nppctm1Yog
Genetic Background: either: (129X1/SvJ) or (involves: 129/Sv * C57BL/6J)

Allelic Composition: Nppclbab/Nppclbab
Genetic Background: B6.PL-Nppclbab/GrsrJ

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
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Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

 MP:0003409 decreased width of hypertrophic chondrocyte zone "decreased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nppctm1Yog/Nppctm1Yog
Genetic Background: either: (129X1/SvJ) or (involves: 129/Sv * C57BL/6J)

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Nppctm1Yog/Nppctm1Yog
Genetic Background: either: (129X1/SvJ) or (involves: 129/Sv * C57BL/6J)

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nppclbab/Nppclbab
Genetic Background: B6.PL-Nppclbab/GrsrJ

 MP:0006394 abnormal vertebral epiphyseal plate morphology "any structural anomaly in the lateral cartilaginous centers of ossification; may be found on the lateral, upper, and/or lower surfaces of the vertebrae at different times during development" [ISBN:0-914294-08-3 "Gray s Anatomy", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nppctm1Yog/Nppctm1Yog
Genetic Background: either: (129X1/SvJ) or (involves: 129/Sv * C57BL/6J)

 MP:0006396 decreased long bone epiphyseal plate size "reduced size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nppctm1Yog/Nppctm1Yog
Genetic Background: either: (129X1/SvJ) or (involves: 129/Sv * C57BL/6J)

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab3atm1Sud/Rab3aEbd
Genetic Background: involves: 129 * C57BL/6J

 MP:0008525 decreased skull height "decrease in the distance between the cranial base and the upper domelike portion of the skull" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nppctm1Yog/Nppctm1Yog
Genetic Background: either: (129X1/SvJ) or (involves: 129/Sv * C57BL/6J)

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Themistm1Hasu/Themis+
Genetic Background: involves: C57BL/6 * CBA

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Nppclbab/Nppclbab
Genetic Background: B6.PL-Nppclbab/GrsrJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nppctm1Yog/Nppctm1Yog
Genetic Background: either: (129X1/SvJ) or (involves: 129/Sv * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028469 Npr2 / Q6VVW5 / natriuretic peptide receptor 2 / P20594*  / complex / reaction






 

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