Skip to main content
SpringerLink
Log in

A novel bioactive porous bredigite (Ca7MgSi4O16) scaffold with biomimetic apatite layer for bone tissue engineering

  • Published:
Journal of Materials Science: Materials in Medicine Aims and scope Submit manuscript

Abstract

The aim of this study was to develop a novel bioactive, degradable and cytocompatible bredigite (Ca7MgSi4O16) scaffold with biomimetic apatite layer for bone tissue engineering. Porous bredigite scaffolds were prepared using polymer sponge method. The bredigite scaffolds with biomimetic apatite layer (BTAP) were obtained by soaking bredigite scaffolds in simulated body fluid (SBF) for 10 days. The porosity and in vitro degradability of BTAP scaffolds were investigated. In addition, osteoblast-like cell morphology, proliferation and differentiation on BTAP scaffolds were evaluated and compared with β-tricalcium phosphate (β-TCP) scaffolds. The results showed that BTAP scaffolds possessed 90% of porosity. The degradation of BTAP scaffolds was comparable to that of β-TCP scaffolds. Cells on BTAP scaffolds spread well and presented a higher proliferation rate and differentiation level as compared with those on β-TCP scaffolds. Our results indicated that BTAP scaffolds were degradable and possessed the function to enhance cell proliferation and differentiation, and might be used as bone tissue engineering materials.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8

Similar content being viewed by others

References

  1. K. KURASHINA, H. KURITA, Q. WU, A. OHTSUKA, H. KOBAYASHI, Biomaterial 13 (2002) 407

    Article  Google Scholar 

  2. M. SATIO, H. SHIMIZU, M. BEPPU, M. TAKAGI, J. Orthop. Sci. 5 (2000) 275

    Article  Google Scholar 

  3. K. OHURA, M. BOHNER, P. HARDOUIN, J. LEMAITRE, G. PASQUIER, B. FLAUTRE, J. Biomed. Mater. Res. 30 (1996) 193

    Article  CAS  Google Scholar 

  4. K. OHSAWA, M. NEO, H. MATSUOKA, H. AKIYAMA, H. ITO, H. KOHNO, T. NAKAMURA, J. Biomed. Mater. Res. 52 (2000) 460

    Article  CAS  Google Scholar 

  5. K. J. BURG, S. PORTER, J. F. KELLAM, Biomaterials 21 (2000) 2247

    Article  Google Scholar 

  6. P. VALERIO, M. M. PEREIRA, A. M. GOES, M. F. LEITE, Biomaterials 25 (2004) 2941

    Article  CAS  Google Scholar 

  7. A. EL-GHANNAM, P. DUCHEYNE, I. M. SHAPIRO, J. Biomed. Mater. Res. 29 (1995) 359

    Article  CAS  Google Scholar 

  8. A. EL-GHANNAM, P. DUCHEYNE, I. M. SHAPIRO, J. Biomed. Mater. Res. 36 (1997) 167

    Article  CAS  Google Scholar 

  9. C. LOTY, J. M. SAUTIER, H. BOULEKACHE, T. KOKUBO, H. M. KIM, J. Biomed. Mater. Res. 49 (2000) 423

    Article  CAS  Google Scholar 

  10. N. OLMO, A. I. MARTÍN, A. J. SALINAS, J. TURNAY, V. R. MARÍA, M. A. LIZARBE, Biomaterials 24 (2003) 3383.

    Article  CAS  Google Scholar 

  11. P. SIRIPHANNON, S. HAYASHI, A. YASUMORI, K. OKADA, J. Mater. Res. 14 (1999) 529

    CAS  Google Scholar 

  12. C. T. WU, J. CHANG, J. Y. WANG, S. Y. NI, W. Y. ZHAI, Biomaterials 26 (2005) 2925

    Article  CAS  Google Scholar 

  13. T. KOKUBO, J. Non-Cryst. Solids. 120 (1990) 138

    Article  CAS  Google Scholar 

  14. N. OZGÜR ENGIN, A. CÜNEYT TAS, J. Eur. Ceram. Soc. 19 (1999) 2569

    Article  Google Scholar 

  15. C. G. BELLOWS, J. E. AUBIN, J. N. M. HEERSCHE, M. E. ANTOSZ, Calcif Tissue Int. 38 (1986) 143

    Article  CAS  Google Scholar 

  16. S. L. ISHAUG, M. J. YASZEMSKI, R. BIZIOS, A. G. MIKOS, J. Biomed. Mater. Res. 28 (1994) 1445

    Article  CAS  Google Scholar 

  17. R. A. HIRST, H. YESILKAYA, E. CLITHEROE, A. RUTMAN, N. DUFTY, T. J. MITCHELL, C. O. CALLAGHAN, P. W. ANDREW, Infect. Immu. 70 (2002) 1017

    Article  CAS  Google Scholar 

  18. O. H. LOWRY, N. R. ROBERTS, M. WU, W. S. HIXTON, E. J. CRAWFORD, J. Biol. Chem. 207 (1954) 19

    CAS  Google Scholar 

  19. M. LIEBERHERR, I. VREVEN, G. VAES, Biochem. Biophys. Acta. 293 (1973) 160

    CAS  Google Scholar 

  20. A. EL-GHANNAM, P. DUCHEYNE, I. M. SHAPIRO, J. Biomed. Mater. Res. 29 (1995) 359

    Article  CAS  Google Scholar 

  21. J. R. JONES, L. L. HENCH, J. Biomed. Mater. Res. Part B: Appl. Biomater. 68 (2004) 36

    Article  Google Scholar 

  22. Y. ZHANG, M. ZHANG, J. Biomed. Mater. Res. 61 (2002) 1

    Article  CAS  Google Scholar 

  23. D. W. HUTMACHER, Biomaterials 21 (2000) 2529

    Article  CAS  Google Scholar 

  24. J. X. LU, M. DESCAMPS, J. DEJOU, G. KOUBI, P. HARDOUIN, J. LEMAITRE, J. P. PROUST, J. Biomed. Mater. Res. 63 (2002) 408

    Article  CAS  Google Scholar 

  25. C. C. LIU, J. K. YEH, J. F. ALOIA, J. Bone Mineral Res. 3 (1988) 104

    Google Scholar 

  26. D. M. REFFITT, N. OGSTON, R. JUGDAOHSINGH, H. F. CHEUNG, B. A. EVANS, R. P. THOMPSON, J. J. POWELL, G. N. HAMPSON, Bone 32 (2003) 127

    Article  CAS  Google Scholar 

  27. I. D. XYNOS, A. J. EDGAR, L. D. K. BUTTERY, L. L. HENCH, J. M. POLAK, J. Biomed. Mater. Res. 55 (2001) 151

    Article  CAS  Google Scholar 

  28. J. E. G. HULSHOFF, K. VON DIJK, J. E. RUIJER, F. J. R. RIETVELD, L. A. GINSEL, J. A. JANSEN, J. Biomed. Mater. Res. 40 (1998) 464

    Article  CAS  Google Scholar 

  29. B. LABAT, A. CHAMSON, J. FREY, J. Biomed. Mater. Res. 29 (1995) 1397

    Article  CAS  Google Scholar 

  30. H. OHGUSHI, Y. DOHI, T. YOSHIKAWA, S. TAMAI, S. TABATA, K. OKUNAGA, T SHIBUYA, J. Biomed. Mater. Res. 32 (1996) 341

    Article  CAS  Google Scholar 

  31. T. J. WEBSTER, C. ERGUN, R. H. DOREMUS, R. W. SIEGEL, R. BIZIOS, Biomaterials 21 (2000) 1803

    Article  CAS  Google Scholar 

  32. Y. F. CHOU, W. B. HUANG, J. DUNN, T. A. MILLER, B. M. WU, Biomaterials 26 (2005) 285

    Article  CAS  Google Scholar 

Download references

Acknowledgments

This work is supported by the National Basic Science Research Program of China (973 Program) (Grant No: 2005CB522704) and Science and Technology Commission of Shanghai Municipality (Grant No: 05JD14005).

Author information

Authors and Affiliations

  1. Biomaterials and Tissue Engineering Research Center, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Dingxi Road, Shanghai, 200050, P. R. China

    Chengtie Wu, Jiang Chang, Wanyin Zhai & Siyu Ni

  2. Graduate School of Chinese Academy of Sciences, 319 Yueyang Road, Shanghai, 200050, P. R. China

    Chengtie Wu

Authors
  1. Chengtie Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jiang Chang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Wanyin Zhai
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Siyu Ni
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jiang Chang.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wu, C., Chang, J., Zhai, W. et al. A novel bioactive porous bredigite (Ca7MgSi4O16) scaffold with biomimetic apatite layer for bone tissue engineering. J Mater Sci: Mater Med 18, 857–864 (2007). https://doi.org/10.1007/s10856-006-0083-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10856-006-0083-0

Keywords

Search

Navigation