Could carnosine or related structures suppress Alzheimer's disease?

AR Hipkiss - Journal of Alzheimer's Disease, 2007 - content.iospress.com
… The protease oxidized protein hydrolase (OPH) is co-… Toxicity of copperamyloid-β-peptide
complex is mediated by the … of Parkinson’s disease (PD) [117], and which can be inhibited by …

[HTML][HTML] The endosomal-lysosomal system: from acidification and cargo sorting to neurodegeneration

YB Hu, EB Dammer, RJ Ren, G Wang - Translational neurodegeneration, 2015 - Springer
… be major sites of protein hydrolase activity acting on soluble … for ESCRT complex function
proposes that these complexes … changes in the proteome that follow inhibition of V-ATPase and …

Small peptide inhibitors of acetyl-peptide hydrolase having an uncommon mechanism of inhibition and a stable bent conformation

A Sandomenico, A Russo, G Palmieri… - Journal of medicinal …, 2012 - ACS Publications
… diseases, such as Alzheimer's disease (AD), because … APEH inhibitors, we have prepared
and screened a complex … The set used here, reported in Table 1, includes aspartic acid as …

The potential role of ubiquitin c-terminal hydrolases in oncogenesis

Y Fang, D Fu, XZ Shen - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2010 - Elsevier
inhibit its hydrolase activity; UCH37 is responsible for the deubiquitinating activity in the 19S
proteasome regulatory complex, … UCH-L3 is a kind of ubiquitin-protein hydrolase involved in …

Mitochondrial poly (ADP-ribose) polymerase: The Wizard of Oz at work

A Brunyanszki, B Szczesny, L Virág, C Szabo - Free Radical Biology and …, 2016 - Elsevier
… of various cellular functions in health and disease. The goal of the current … ADP-ribosyl
protein hydrolase-3 … Inhibition of complex V would be expected to attenuate mitochondrial ATP …

Are amyloid‐degrading enzymes viable therapeutic targets in Alzheimer's disease?

NN Nalivaeva, C Beckett, ND Belyaev… - Journal of …, 2012 - Wiley Online Library
… their synthesis from the amyloid precursor protein and their removal by amyloid-degrading …
, in this case, NEP did not degrade the amyloid peptide but appeared to act by inhibiting the …

The human red blood cell proteome and interactome

SR Goodman, A Kurdia, L Ammann… - Experimental …, 2007 - journals.sagepub.com
… The elimination of hemoglobin is an important and difficult problem in RBC proteomics.
The use of … Rab GDP dissociation inhibitor alpha … Similar to oxidized protein hydrolase

[HTML][HTML] Neurotransmitters in prevention and treatment of Alzheimer's disease

Z Yang, Y Zou, L Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
… the formation of protein hydrolase-insensitive neurofibrillary … inhibitor, reduced Aβ amyloid
deposition and APP precursorcomplex and ketoglutarate dehydrogenase complex, which …

Proteomic studies on low-and high-grade human brain astrocytomas

…, B Zanotti, M Skrap, S Pizzolitto… - Journal of proteome …, 2005 - ACS Publications
… mM EDTA, and 1X protease inhibitors cocktail. Successively, … , we found that ubiquitin-protein
hydrolase, protein disulfide … acidic protein, and T-complex protein 1 epsilon subunit were …

Protein transnitrosylation signaling networks contribute to inflammaging and neurodegenerative disorders

T Nakamura, C Oh, X Zhang… - Antioxidants & redox …, 2021 - liebertpub.com
… to nNOS, via S-nitrosylation to inhibit receptor overactivation. … In addition, inhibiting
caspase-9/XIAP complex formation … , and a ubiquitin protein hydrolase, which function in disparate …