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Atac2 Ada2a-containing complex component 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35113, updated on 10-May-2024

Summary

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Official Symbol
Atac2provided by FlyBase
Official Full Name
Ada2a-containing complex component 2provided by FlyBase
Primary source
FLYBASE:FBgn0032691
Locus tag
Dmel_CG10414
See related
AllianceGenome:FB:FBgn0032691
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10414; dAtac2; dATAC2; Dmel\CG10414; KAT14
Summary
Enables H2A histone acetyltransferase activity and H4 histone acetyltransferase activity. Involved in several processes, including histone acetylation; intestinal stem cell homeostasis; and positive regulation of histone H4-K16 acetylation. Part of ATAC complex. Is expressed in several structures, including embryonic/larval midgut primordium and germ layer. Orthologous to human KAT14 (lysine acetyltransferase 14). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
36F7-36F7; 2-53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18609576..18612249, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18609576..18612249, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Intraflagellar transport 46 Neighboring gene Misexpression suppressor of ras 3 Neighboring gene Cytochrome P450 310a1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of a histone acetyltransferase as a novel regulator of Drosophila intestinal stem cells. Ma Y, et al. FEBS Lett, 2013 May 21. PMID 23535028
  2. Moco biosynthesis and the ATAC acetyltransferase engage translation initiation by inhibiting latent PKR activity. Suganuma T, et al. J Mol Cell Biol, 2016 Feb. PMID 26705305
  3. ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding. Suganuma T, et al. Nat Struct Mol Biol, 2008 Apr. PMID 18327268
  4. A metazoan ATAC acetyltransferase subunit that regulates mitogen-activated protein kinase signaling is related to an ancient molybdopterin synthase component. Suganuma T, et al. Mol Cell Proteomics, 2012 May. PMID 22345504, Free PMC Article
  5. Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies. Hirano Y, et al. Nat Commun, 2016 Nov 14. PMID 27841260, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables histone H2A acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H4 acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ATAC complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
Ada2a-containing complex component 2
Names
ATAC complex component 2
Atac2-PA
CG10414-PA
lysine acetyltransferase 14
NP_609889.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18609576..18612249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136045.3 → NP_609889.1  Ada2a-containing complex component 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609889.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJ73
    Related
    FBpp0080629
    Conserved Domains (3) summary
    smart00249
    Location:14 → 63
    PHD; PHD zinc finger
    TIGR01575
    Location:639 → 753
    rimI; ribosomal-protein-alanine acetyltransferase
    pfam00583
    Location:676 → 744
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJ73 Q9VJ73

Gene LinkOut

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