Saint Jerome, who translated the Bible into Latin from the original Greek and Hebrew, is shown reading in his study. He is surrounded by books, an inkwell, an unlit candle and a crucifix (which seems not to be attached to the desk and may be a vision). A quail (a bird also included by Catena in 'A Warrior adoring the Infant Christ and the Virgin' and possibly symbolic of truth) and Jerome's traditional attribute of a lion (from whose paw, according to legend, the saint had removed a thorn) are seen in the foreground.
The pink and blue of Jerome's robes and the blue of his cardinal's hat are unusual in representations of the saint. Saint Jerome was traditionally shown in red, although until the 1460s it was customary for cardinals to wear a violet or blue cape unless granted the privilege of wearing red when acting on papal business.
There is another version of the painting in Frankfurt-am-Main.