US20140371560A1 - Body-Mountable Devices and Methods for Embedding a Structure in a Body-Mountable Device - Google Patents
Body-Mountable Devices and Methods for Embedding a Structure in a Body-Mountable Device Download PDFInfo
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- US20140371560A1 US20140371560A1 US13/918,522 US201313918522A US2014371560A1 US 20140371560 A1 US20140371560 A1 US 20140371560A1 US 201313918522 A US201313918522 A US 201313918522A US 2014371560 A1 US2014371560 A1 US 2014371560A1
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- mountable device
- polymer layer
- conductive loops
- polymer
- eye
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- NXGQWVKSKOYDIA-UHFFFAOYSA-N O=O.OO Chemical compound O=O.OO NXGQWVKSKOYDIA-UHFFFAOYSA-N 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0002—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network
- A61B5/0015—Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network characterised by features of the telemetry system
- A61B5/002—Monitoring the patient using a local or closed circuit, e.g. in a room or building
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/682—Mouth, e.g., oral cavity; tongue; Lips; Teeth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
- A61B5/6814—Head
- A61B5/6821—Eye
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- G—PHYSICS
- G02—OPTICS
- G02C—SPECTACLES; SUNGLASSES OR GOGGLES INSOFAR AS THEY HAVE THE SAME FEATURES AS SPECTACLES; CONTACT LENSES
- G02C7/00—Optical parts
- G02C7/02—Lenses; Lens systems ; Methods of designing lenses
- G02C7/04—Contact lenses for the eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using enzyme electrodes, e.g. with immobilised oxidase
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T156/00—Adhesive bonding and miscellaneous chemical manufacture
- Y10T156/10—Methods of surface bonding and/or assembly therefor
- Y10T156/1002—Methods of surface bonding and/or assembly therefor with permanent bending or reshaping or surface deformation of self sustaining lamina
- Y10T156/1028—Methods of surface bonding and/or assembly therefor with permanent bending or reshaping or surface deformation of self sustaining lamina by bending, drawing or stretch forming sheet to assume shape of configured lamina while in contact therewith
Definitions
- a body-mountable device may be configured to monitor health-related information based on at least one analyte detected in a fluid of a user wearing the body-mountable device.
- the body-mountable device may comprise an eye-mountable device that may be in the form of a contact lens that includes a sensor configured to detect the at least one analyte (e.g., glucose) in a tear film of a user wearing the eye-mountable device.
- the body-mountable device may also be configured to monitor various other types of health-related information.
- a body-mountable device in one aspect, includes: a transparent polymer, wherein the transparent polymer defines a posterior side and an anterior side of the body-mountable device; and a structure embedded in the transparent polymer, wherein the structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna, wherein the antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter.
- a method involves: forming a first polymer layer, such that the first polymer layer has a curvature, wherein the first polymer layer defines a posterior side of a body-mountable device; positioning a structure on the first polymer layer, wherein the structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna, and wherein the antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter; conforming the structure positioned on the first polymer layer to the curvature of the first polymer layer; and forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer and the second polymer layer, wherein the second polymer layer defines an anterior side of the body-mountable device.
- a system includes means for forming a first polymer layer, such that the first polymer layer has a curvature, wherein the first polymer layer defines a posterior side of a body-mountable device; means for positioning a structure on the first polymer layer, wherein the structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna, and wherein the antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter; means for conforming the structure positioned on the first polymer layer to the curvature of the first polymer layer; and means for forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer and the second polymer layer, wherein the second polymer layer defines an anterior side of the body-mountable device.
- FIG. 1 is a block diagram of a system that includes an eye-mountable device in wireless communication with an external reader, according to an example embodiment.
- FIG. 2 a is a top view of a structure, according to an example embodiment.
- FIG. 2 b is a side cross-section view of the structure shown in FIG. 2 a , according to an example embodiment.
- FIG. 3 a is a top view of an eye-mountable device, according to an example embodiment.
- FIG. 3 b is a side view of the eye-mountable device shown in FIG. 3 a , according to an example embodiment.
- FIG. 3 c is a side cross-section view of the eye-mountable device shown in FIG. 3 a while mounted to a corneal surface of an eye, according to an example embodiment.
- FIG. 3 d is a side cross-section view showing tear film layers surrounding the surfaces of the eye-mountable device mounted as shown in FIG. 3 c , according to an example embodiment.
- FIG. 4 is a top view of another structure, according to an example embodiment.
- FIG. 5 is a top view of yet another structure, according to an example embodiment.
- FIG. 6 is a flow chart illustrating a method, according to an example embodiment.
- FIG. 7 a is an illustration of formation of a first polymer layer, according to an example embodiment.
- FIG. 7 b is an illustration of positioning a structure on a first polymer layer, according to an example embodiment.
- FIG. 7 c is an illustration of a structure positioned on a first polymer layer, according to an example embodiment.
- FIG. 7 d is an illustration of conforming a structure positioned on a first polymer layer to a curvature of the first polymer layer, according to an example embodiment.
- FIG. 7 e is an illustration of formation of a second polymer layer, according to an example embodiment.
- a body-mountable device may include a transparent polymer and a structure embedded in the transparent polymer that has an outer diameter and an inner diameter.
- the transparent polymer defines a posterior side and an anterior side of the body-mountable device.
- the structure includes a sensor configured to detect an analyte and an antenna that includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter.
- the plurality of conductive loops can reduce buckling of the structure (e.g., one or more protrusions from a surface of the structure) when it is bent to conform to a curvature of the transparent polymer.
- the anterior side of the body-mountable device refers to an outward-facing side of the body-mountable device
- the posterior side of the body-mountable device refers to an inward-facing side of the body-mountable device.
- the anterior side corresponds to a side of the eye-mountable device that is facing outward and thus not touching the eye of the user.
- the posterior side corresponds to a side of the eye-mountable device that is facing inward and thus touching the eye of the user.
- a body-mountable device may be configured to monitor health-related information based on at least one analyte detected in a fluid of a user wearing the body-mountable device.
- An example body-mountable device that comprises an eye-mountable device that is configured to detect the at least one analyte in a tear film of a user wearing the eye-mountable device will now be described in greater detail.
- FIG. 1 is a block diagram of a system 100 with an eye-mountable device 110 in wireless communication with an external reader 180 , according to an example embodiment.
- the exposed regions of the eye-mountable device 110 are made of a polymeric material 120 formed to be contact-mounted to a corneal surface of an eye.
- the polymeric material 120 may comprise a first polymer layer and a second polymer layer.
- Substrate 130 is embedded in the polymeric material 120 to provide a mounting surface for a power supply 140 , a controller 150 , bio-interactive electronics 160 , and an antenna 170 .
- the bio-interactive electronics 160 are operated by the controller 150 .
- the power supply 140 supplies operating voltages to the controller 150 and/or the bio-interactive electronics 160 .
- the antenna 170 is operated by the controller 150 to communicate information to and/or from the eye-mountable device 110 .
- the antenna 170 , the controller 150 , the power supply 140 , and the bio-interactive electronics 160 can all be situated on the embedded substrate 130 . Because the eye-mountable device 110 includes electronics and is configured to be contact-mounted to an eye, it may also be referred to as an ophthalmic electronics platform.
- the polymeric material 120 can have a concave surface configured to adhere (“mount”) to a moistened corneal surface (e.g., by capillary forces with a tear film coating the corneal surface). Additionally or alternatively, the eye-mountable device 110 can be adhered by a vacuum force between the corneal surface and the polymeric material due to the concave curvature. While mounted with the concave surface against the eye, the anterior or outward-facing surface of the polymeric material 120 can have a convex curvature that is formed to not interfere with eye-lid motion while the eye-mountable device 110 is mounted to the eye.
- the polymeric material 120 can be a substantially transparent curved polymeric disk shaped similarly to a contact lens.
- the polymeric material 120 can include one or more bio-compatible materials, such as those employed for use in contact lenses or other ophthalmic applications involving direct contact with the corneal surface.
- the polymeric material 120 can optionally be formed in part from such bio-compatible materials or can include an outer coating with such bio-compatible materials.
- the polymeric material 120 can include materials configured to moisturize the corneal surface, such as hydrogels and the like.
- the polymeric material 120 can be a deformable (“non-rigid”) material to enhance wearer comfort.
- the polymeric material 120 can be shaped to provide a predetermined, vision-correcting optical power, such as can be provided by a contact lens.
- the substrate 130 includes one or more surfaces suitable for mounting the bio-interactive electronics 160 , the controller 150 , the power supply 140 , and the antenna 170 .
- the substrate 130 can be employed both as a mounting platform for chip-based circuitry (e.g., by flip-chip mounting) and/or as a platform for patterning conductive materials (e.g., gold, platinum, palladium, titanium, copper, aluminum, silver, metals, other conductive materials, combinations of these, etc.) to create electrodes, interconnects, antennae, etc.
- substantially transparent conductive materials e.g., indium tin oxide
- the antenna 170 can be formed by depositing a pattern of gold or another conductive material on the substrate 130 .
- interconnects 151 , 157 between the controller 150 and the bio-interactive electronics 160 , and between the controller 150 and the antenna 170 , respectively, can be formed by depositing suitable patterns of conductive materials on the substrate 130 .
- a combination of resists, masks, and deposition techniques can be employed to pattern materials on the substrate 130 .
- the substrate 130 can be a relatively rigid polymeric material, such as polyethylene terephthalate (“PET”), paralyene, or another material sufficient to structurally support the circuitry and/or electronics within the polymeric material 120 .
- PET polyethylene terephthalate
- the eye-mountable device 110 can alternatively be arranged with a group of unconnected substrates rather than a single substrate.
- the controller 150 and a bio-sensor or other bio-interactive electronic component can be mounted to one substrate, while the antenna 170 is mounted to another substrate and the two can be electrically connected via the interconnects 157 .
- the bio-interactive electronics 160 (and the substrate 130 ) can be positioned away from a center of the eye-mountable device 110 and thereby avoid interference with light transmission to the eye through the center of the eye-mountable device 110 .
- the substrate 130 can be embedded around the periphery (e.g., near the outer circumference) of the disk.
- the bio-interactive electronics 160 (and the substrate 130 ) can be positioned in a center region of the eye-mountable device 110 .
- the bio-interactive electronics 160 and/or the substrate 130 can be substantially transparent to incoming visible light to mitigate interference with light transmission to the eye.
- the bio-interactive electronics 160 can include a pixel array 164 that emits and/or transmits light to be perceived by the eye according to display driver instructions.
- the bio-interactive electronics 160 can optionally be positioned in the center of the eye-mountable device so as to generate perceivable visual cues to a wearer of the eye-mountable device 110 , such as by displaying information via the pixel array 164 .
- the substrate 130 can be shaped as a flattened ring with a radial width dimension sufficient to provide a mounting platform for the embedded electronics components.
- the substrate 130 can have a thickness sufficiently small to allow the substrate 130 to be embedded in the polymeric material 120 without influencing the profile of the eye-mountable device 110 .
- the substrate 130 can have a thickness sufficiently large to provide structural stability suitable for supporting the electronics mounted thereon.
- the substrate 130 can be shaped as a ring with a 1 centimeter diameter, a radial thickness of approximately 1 millimeter, and a thickness of about 50 micrometers.
- the substrate 130 can optionally be aligned with the curvature of the anterior side of the eye-mountable device 110 .
- the power supply 140 is configured to harvest ambient energy to power the controller 150 and the bio-interactive electronics 160 .
- a radio-frequency energy harvesting antenna 142 can capture energy from incident radio radiation.
- solar cell(s) 144 (“photovoltaic cells”) can capture energy from incoming ultraviolet, visible, and/or infrared radiation.
- an inertial power scavenging system (not shown) can be included to capture energy from ambient vibrations.
- the energy-harvesting antenna 142 can optionally be a dual-purpose antenna that is also used to communicate information to the external reader 180 . That is, the functions of the antenna 170 and the energy harvesting antenna 142 can be accomplished with the same physical antenna.
- a rectifier/regulator 146 can be used to condition the captured energy to a stable DC supply voltage 141 that is supplied to the controller 150 .
- the energy harvesting antenna 142 can receive incident radio frequency radiation. Varying electrical signals on the leads of the energy harvesting antenna 142 are output to the rectifier/regulator 146 .
- the rectifier/regulator 146 rectifies the varying electrical signals to a DC voltage and regulates the rectified DC voltage to a level suitable for operating the controller 150 .
- output voltage from the solar cell(s) 144 can be regulated to a level suitable for operating the controller 150 .
- the rectifier/regulator 146 can include one or more energy storage devices arranged to mitigate high frequency variations in the ambient energy harvesting antenna 142 and/or solar cell(s) 144 .
- an energy storage device e.g., capacitor, inductor, etc.
- an energy storage device can be connected to the output of the rectifier/regulator 146 so as to function as a low-pass filter.
- the controller 150 is turned on when the DC supply voltage 141 is provided to the controller 150 , and the logic in the controller 150 operates the bio-interactive electronics 160 and the antenna 170 .
- the controller 150 can include logic circuitry configured to operate the bio-interactive electronics 160 so as to interact with a biological environment of the eye-mountable device 110 .
- the interaction could involve the use of one or more components, such as an analyte bio-sensor 162 , in bio-interactive electronics 160 to obtain input from the biological environment.
- the interaction could involve the use of one or more components, such as the pixel array 164 , to provide an output to the biological environment.
- a sensor interface module 152 can be included for operating the analyte bio-sensor 162 .
- the analyte bio-sensor 162 can be, for example, an amperometric electrochemical sensor that includes a working electrode and a reference electrode. Application of an appropriate voltage between the working and reference electrodes can cause an analyte to undergo electrochemical reactions (e.g., reduction and/or oxidation reactions) at the working electrode to generate an amperometric current.
- the amperometric current can be dependent on the analyte concentration, and thus the amount of amperometric current can provide an indication of analyte concentration.
- the sensor interface module 152 can be a potentiostat configured to apply a voltage difference between the working and reference electrodes while measuring a current through the working electrode.
- At least a portion of the bio-interactive electronics 160 , the controller 150 , the power supply, and/or the antenna 170 can be embedded in the substrate 130 .
- at least a portion of the bio-interactive electronics 160 e.g., the analyte bio-sensor 162
- a reagent can also be included to sensitize the electrochemical sensor to desired analytes.
- a layer of glucose oxidase (“GOD”) can be situated around the working electrode to catalyze glucose into hydrogen peroxide (H 2 O 2 ). The hydrogen peroxide can then be oxidized at the working electrode, which releases electrons to the working electrode, which generates a current.
- GOD glucose oxidase
- the current generated by either reduction or oxidation reactions can be approximately proportionate to the reaction rate. Further, the reaction rate can be dependent on the rate of analyte molecules reaching the electrochemical sensor electrodes to fuel the reduction or oxidation reactions, either directly or catalytically through a reagent. In a steady state, where analyte molecules flow and/or diffuse to the electrochemical sensor electrodes from a sampled region at approximately the same rate that additional analyte molecules diffuse to the sampled region from surrounding regions, the reaction rate can be approximately proportionate to the concentration of the analyte molecules. The current can thus provide an indication of the analyte concentration.
- the controller 150 can optionally include a display driver module 154 for operating a pixel array 164 .
- the pixel array 164 can be an array of separately programmable light transmitting, light reflecting, and/or light emitting pixels arranged in rows and columns.
- the individual pixel circuits can optionally include liquid crystal technologies, microelectromechanical technologies, emissive diode technologies, etc. to selectively transmit, reflect, and/or emit light according to information from the display driver module 154 .
- Such a pixel array 164 can also optionally include more than one color of pixels (e.g., red, green, and blue pixels) to render visual content in color.
- the display driver module 154 can include, for example, one or more data lines providing programming information to the separately programmed pixels in the pixel array 164 and one or more addressing lines for setting groups of pixels to receive such programming information.
- a pixel array 164 situated on the eye can also include one or more lenses to direct light from the pixel array to a focal plane perceivable by the eye.
- the controller 150 can also include a communication circuit 156 for sending and/or receiving information via the antenna 170 .
- the communication circuit 156 can optionally include one or more oscillators, mixers, frequency injectors, etc. to modulate and/or demodulate information on a carrier frequency to be transmitted and/or received by the antenna 170 .
- the eye-mountable device 110 is configured to indicate an output from a bio-sensor by modulating an impedance of the antenna 170 in a manner that is perceivable by the external reader 180 .
- the communication circuit 156 can cause variations in the amplitude, phase, and/or frequency of backscatter radiation from the antenna 170 , and such variations can be detected by the external reader 180 .
- the controller 150 is connected to the bio-interactive electronics 160 via interconnects 151 .
- a patterned conductive material e.g., gold, platinum, palladium, titanium, copper, aluminum, silver, metals, combinations of these, etc.
- the controller 150 is connected to the antenna 170 via interconnects 157 .
- FIG. 1 the block diagram shown in FIG. 1 is described in connection with functional modules for convenience in description.
- embodiments of the eye-mountable device 110 can be arranged with one or more of the functional modules (“sub-systems”) implemented in a single chip, integrated circuit, and/or physical feature.
- the rectifier/regulator 146 is illustrated in the power supply block 140
- the rectifier/regulator 146 can be implemented in a chip that also includes the logic elements of the controller 150 and/or other features of the embedded electronics in the eye-mountable device 110 .
- the DC supply voltage 141 that is provided to the controller 150 from the power supply 140 can be a supply voltage that is provided on a chip by rectifier and/or regulator components the same chip. That is, the functional blocks in FIG. 1 shown as the power supply block 140 and controller block 150 need not be implemented as separated modules.
- one or more of the functional modules described in FIG. 1 can be implemented by separately packaged chips electrically connected to one another.
- the energy harvesting antenna 142 and the antenna 170 can be implemented with the same physical antenna.
- a loop antenna can both harvest incident radiation for power generation and communicate information via backscatter radiation.
- the external reader 180 includes an antenna 188 (or group of more than one antennae) to send and receive wireless signals 171 to and from the eye-mountable device 110 .
- the external reader 180 also includes a computing system with a processor 186 in communication with a memory 182 .
- the memory 182 is a non-transitory computer-readable medium that can include, without limitation, magnetic disks, optical disks, organic memory, and/or any other volatile (e.g., RAM) or non-volatile (e.g., ROM) storage system readable by the processor 186 .
- the memory 182 can include a data storage 183 to store indications of data substrates, such as sensor readings (e.g., from the analyte bio-sensor 162 ), program settings (e.g., to adjust behavior of the eye-mountable device 110 and/or external reader 180 ), etc.
- the memory can also include program instructions 184 for execution by the processor 186 to cause the external reader to perform processes specified by the program instructions 184 .
- the program instructions 184 can cause external reader 180 to provide a user interface that allows for retrieving information communicated from the eye-mountable device 110 (e.g., sensor outputs from the analyte bio-sensor 162 ).
- the external reader 180 can also include one or more hardware components for operating the antenna 188 to send and receive the wireless signals 171 to and from the eye-mountable device 110 .
- one or more hardware components for operating the antenna 188 to send and receive the wireless signals 171 to and from the eye-mountable device 110 .
- oscillators, frequency injectors, encoders, decoders, amplifiers, filters, etc. can drive the antenna 188 according to instructions from the processor 186 .
- the external reader 180 can be a smart phone, digital assistant, or other portable computing device with wireless connectivity sufficient to provide the wireless communication link 171 .
- the external reader 180 can also be implemented as an antenna module that can be plugged into a portable computing device, such as in an example where the communication link 171 operates at carrier frequencies not commonly employed in portable computing devices.
- the external reader 180 is a special-purpose device configured to be worn relatively near a wearer's eye to allow the wireless communication link 171 to operate with a low power budget.
- the external reader 180 can be integrated in a piece of jewelry such as a necklace, earing, etc. or integrated in an article of clothing worn near the head, such as a hat, headband, etc.
- the system 100 can be operated to monitor the analyte concentration in tear film on the surface of the eye.
- the eye-mountable device 110 can be configured as a platform for an ophthalmic analyte bio-sensor.
- the tear film is an aqueous layer secreted from the lacrimal gland to coat the eye.
- the tear film is in contact with the blood supply through capillaries in the substrate of the eye and includes many biomarkers found in blood that are analyzed to characterize a person's health condition(s).
- the tear film includes glucose, calcium, sodium, cholesterol, potassium, other biomarkers, etc.
- the biomarker concentrations in the tear film can be systematically different than the corresponding concentrations of the biomarkers in the blood, but a relationship between the two concentration levels can be established to map tear film biomarker concentration values to blood concentration levels.
- the tear film concentration of glucose can be established (e.g., empirically determined) to be approximately one tenth the corresponding blood glucose concentration.
- measuring tear film analyte concentration levels provides a non-invasive technique for monitoring biomarker levels in comparison to blood sampling techniques performed by lancing a volume of blood to be analyzed outside a person's body.
- the ophthalmic analyte bio-sensor platform disclosed here can be operated substantially continuously to enable real time monitoring of analyte concentrations.
- the external reader 180 can emit radio frequency radiation 171 that is harvested to power the eye-mountable device 110 via the power supply 140 .
- Radio frequency electrical signals captured by the energy harvesting antenna 142 (and/or the antenna 170 ) are rectified and/or regulated in the rectifier/regulator 146 and a regulated DC supply voltage 647 is provided to the controller 150 .
- the radio frequency radiation 171 thus turns on the electronic components within the eye-mountable device 110 .
- the controller 150 operates the analyte bio-sensor 162 to measure an analyte concentration level.
- the sensor interface module 152 can apply a voltage between a working electrode and a reference electrode in the analyte bio-sensor 162 sufficient to cause the analyte to undergo an electrochemical reaction at the working electrode.
- the current through the working electrode can be measured to provide the sensor output indicative of the analyte concentration.
- the controller 150 can operate the antenna 170 to communicate the sensor results back to the external reader 180 (e.g., via the communication circuit 156 ).
- the sensor result can be communicated by, for example, modulating an impedance of the antenna 170 such that the modulation in impedance is detected by the external reader 180 .
- the modulation in antenna impedance can be detected by, for example, backscatter radiation from the antenna 170 .
- the system 100 can operate to non-continuously (“intermittently”) supply energy to the eye-mountable device 110 to power the on-board controller 150 and the bio-interactive electronics 160 .
- radio frequency radiation 171 can be supplied to power the eye-mountable device 110 long enough to carry out a tear film analyte concentration measurement and communicate the results.
- the supplied radio frequency radiation can provide sufficient power to charge two electrodes to a potential sufficient to induce electrochemical reactions, measure the resulting amperometric current, and modulate the antenna impedance to adjust the backscatter radiation in a manner indicative of the measured current.
- the supplied radio frequency radiation 171 can be considered an interrogation signal from the external reader 180 to the eye-mountable device 110 to request a measurement.
- the external reader 180 can accumulate a set of analyte concentration measurements over time without continuously powering the eye-mountable device 110 .
- FIG. 2 a is a top view of a structure 230 , according to an example embodiment.
- the structure 230 has an outer diameter 232 and an inner diameter 234 and includes electronics 240 , electronics 250 , a sensor 260 , and an antenna 270 disposed thereon.
- the structure 230 may take the form of or be similar in form to the substrate 130 .
- the structure 230 can have various sizes. For instance, the size of the structure 230 may depend on which analyte an eye-mountable device is configured to detect. In an example, the structure 230 has a maximum height of approximately 50 between 150 micrometers. Of course, other maximum heights of the structure 230 are possible as well.
- the structure 230 has a height dimension of at least 50 micrometers. In other words, at some point of the structure 230 , the height of the structure 230 may be at least 50 micrometers. In an example, this height dimension may correspond to a maximum height of the structure 230 . In accordance with the present disclosure, the maximum height of the structure 230 corresponds to the height of the structure 230 at its highest point. For instance, in the example where the structure 230 comprises the sensor 260 and the electronics 250 , the height of the structure 230 may vary (and thus the structure 230 may have various height dimensions).
- the height of the structure 230 may be higher at a point where the electronics 250 is mounted on the structure 230 , whereas the height may be lower at a point where there is no chip on the structure 230 .
- the maximum height may correspond to the point where the electronics 250 is mounted on the structure 230 .
- the outer diameter 232 and the inner diameter 234 could take various different forms in various different embodiments.
- the outer diameter can have a length between 12.5 and 15 millimeters.
- the inner diameter can have a length greater than 8 millimeters. And other lengths of the outer diameter 232 and/or inner diameter 234 are possible as well.
- the electronics 240 and 250 could be configured in a variety of ways.
- the electronics 240 and/or the electronics 250 may be configured to operate the sensor 260 and the antenna 270 .
- the electronics 240 and/or the electronics 250 may be configured for wireless communication with an external reader, such as the external reader 180 .
- the electronics 240 and the electronics 250 may provide a bias voltage for the sensor 260 and adjust backscattered radio frequency (RF) that is proportional to a current that is passing through the sensor 260 .
- RF radio frequency
- the electronics 240 and the electronics 250 could take various different forms in various different embodiments.
- the electronics 240 and/or the electronics 250 can comprise a chip including one or more logical elements.
- the electronics 240 and/or the electronics 250 may take the form of or be similar in form to the controller 150 .
- the sensor 260 is configured to detect one or more analytes.
- the sensor 260 could take various different forms in various different embodiments.
- the sensor 260 can comprise a pair of electrodes, such as a working electrode and a reference electrode.
- the sensor 260 may take the form of or be similar in form to the analyte bio-sensor 162 .
- the antenna 270 is configured for communications and/or harvesting energy as described herein.
- the antenna 270 includes a plurality of conductive loops 272 spaced apart from each other between the outer diameter 232 and the inner diameter 234 .
- the plurality of conductive loops 272 includes three conductive loops 272 A, 272 B, and 272 C.
- a plurality of conductive loops may include more than three conductive loops, such as five conductive loops, nine conductive loops, etc.
- the conductive loops 272 A, 272 B, and 272 C are connected in parallel.
- each of the conductive loops in the plurality of conductive loops 272 is electrically connected to the electronics 240 , the electronics 250 , and the sensor 260 via a first connection 274 and a second connection 276 .
- the electronics 240 , the electronics 250 , and the sensor 260 are electrically connected via the first connection 274 and the second connection 276 .
- the first connection 274 and the second connection 276 may take the form of or be similar in form to the interconnects 151 and 157 .
- the conductive loops 272 A, 272 B, and 272 C are substantially concentric.
- substantially concentric refers to exactly concentric and/or one or more deviations from exactly concentric that do not significantly impact embedding a structure in a body-mountable device as described herein.
- the conductive loops 272 A, 272 B, and 272 C are spaced apart from each other between the outer diameter 232 and the inner diameter 234 .
- the conductive loops 272 A, 272 B, and 272 C can be spaced apart from adjacent conductive loops by a distance between 100 to 200 micrometers. Other distances are possible as well.
- one of the conductive loops 272 A, 272 B, and 272 C can have a width of 333 micrometers. Other widths of the conductive loops 272 A, 272 B, and 272 C are possible as well. Moreover, in some embodiments, the conductive loops 272 A, 272 B, and 272 C can each have the same width (e.g., the conductive loops 272 A, 272 B, and 272 C can each have a width of 333 micrometers). However, in some embodiments, the conductive loops 272 A, 272 B, and 272 C might not have the same width.
- Each conductive loop in the plurality of conductive loops 272 can comprise a respective metal layer disposed between respective polymer layers. With this arrangement, the polymer layers might block moisture from the metal layer.
- FIG. 2 b is a side cross-section view of the structure shown in FIG. 2 a , according to an example embodiment. As shown in FIG. 2 b , the conductive loop 272 A comprises a metal layer 280 disposed between polymer layers 282 A and 282 B.
- the respective metal layers of the conductive loops 272 B and 272 C may take the form of or be similar in form to the to the metal layer 280 , and the respective polymer layers of the conductive loops 272 B and 272 C may take the form of or be similar in form to the polymer layers 282 A and 282 B.
- the metal layer 280 can comprise gold or another conductive material that can be deposited on the structure 230 , such as platinum, palladium, titanium, carbon, aluminum, copper, silver, and/or silver-chloride. And in at least one such embodiment, the metal layer 280 can have a thickness between 5 and 30 micrometers. Other thicknesses of the metal layer 280 are possible as well. In an example, the metal layer 280 can be formed by a process that includes electroplating.
- the polymer layers 282 A and 282 B can comprise a relatively rigid transparent polymer, such as PET or paralyene. And in at least one such embodiment, the polymer layers 282 A and 282 B can have a thickness between 10 and 50 micrometers, such as 15 micrometers. Other thicknesses of the polymer layers 282 A and 282 B are possible as well. In an example, the polymer layers 282 A and 282 B can be formed by a process that includes chemical vapor deposition.
- the plurality of conductive loops 272 can be formed by a process that includes etching a portion of a metal layer disposed between polymer layers with an inductively coupled plasma, such as an oxygen plasma.
- FIG. 3 a is a top view of an eye-mountable electronic device 310 .
- FIG. 3 b is a side view of the eye-mountable electronic device 310 shown in FIG. 3 a . It is noted that relative dimensions in FIGS. 3 a and 3 b are not necessarily to scale, but have been rendered for purposes of explanation only in describing the arrangement of the eye-mountable electronic device 310 .
- the eye-mountable device 310 is formed of a transparent polymer 320 shaped as a curved disk.
- the transparent polymer 320 can be a substantially transparent material to allow incident light to be transmitted to the eye while the eye-mountable device 310 is mounted to the eye.
- the transparent polymer 320 can be a bio-compatible material similar to those employed to form vision correction and/or cosmetic contact lenses in optometry, such as PET, polymethyl methacrylate (“PMMA”), silicone hydrogels, combinations of these, etc.
- the transparent polymer 320 could take the form of or be similar in form to the polymeric material 120 .
- the transparent polymer 320 can be formed with one side having a posterior side 326 (i.e., concave surface) suitable to fit over a corneal surface of an eye.
- the opposing side of the disk can have anterior side 324 (i.e., convex surface) that does not interfere with eyelid motion while the eye-mountable device 310 is mounted to the eye.
- a circular outer side edge 328 connects the posterior side 326 and anterior side 324 .
- the eye-mountable device 310 can have dimensions similar to a vision correction and/or cosmetic contact lenses, such as a diameter of approximately 1 centimeter, and a thickness of about 0.1 to about 0.5 millimeters. However, the diameter and thickness values are provided for explanatory purposes only. In some embodiments, the dimensions of the eye-mountable device 310 can be selected according to the size and/or shape of the corneal surface and/or the scleral surface of the wearer's eye.
- the anterior side 324 faces outward to the ambient environment while the posterior side 326 faces inward, toward the corneal surface.
- the anterior side 324 can therefore be considered an outer, top surface of the eye-mountable device 310 whereas the posterior side 326 can be considered an inner, bottom surface.
- the “top” view shown in FIG. 3 a is facing the anterior side 324 .
- the structure 330 is embedded in the transparent polymer 320 .
- the substrate 330 can be embedded to be situated along an outer periphery 322 of the transparent polymer 320 , away from a center region 321 .
- the structure 330 does not interfere with vision because it is too close to the eye to be in focus and is positioned away from the center region 321 where incident light is transmitted to the light-sensing portions of the eye.
- the structure 330 can take the form or be similar in form to the substrate 130 and/or the structure 230 .
- the structure 330 has an outer diameter 332 and an inner diameter 334 and includes electronics 340 , electronics 350 , a sensor 360 , and an antenna 370 disposed thereon.
- the outer diameter 332 may take the form of or be similar in form to the outer diameter 232
- the inner diameter 334 may take the form of or be similar in form to the inner diameter 234
- the electronics 340 may take the form of or be similar in form to the controller 150 and/or the electronics 240
- the electronics 350 may take the form or be similar in form to the controller 150 and/or the electronics 250
- the sensor 360 may take the form or be similar in form to the bio-analyte sensor 162 and/or the sensor 260 .
- the antenna 370 is configured for communications and/or harvesting energy, like the antenna 270 is configured for communications and/or harvesting energy.
- the antenna 370 includes a plurality of conductive loops 372 spaced apart from each other between the outer diameter 332 and the inner diameter 334 .
- the plurality of conductive loops 372 includes three conductive loops 372 A, 372 B, and 372 C.
- a plurality of conductive loops may include more than three conductive loops, such as five conductive loops, nine conductive loops, etc.
- the conductive loops 372 A, 372 B, and 372 C may move relative to each other.
- the conductive loops 372 A, 372 B, and 372 C can have an arrangement similar to an arrangement of the conductive loops 272 A, 272 B, and 272 C. As shown in FIGS. 3 a and 3 b , the conductive loops 372 A, 372 B, and 272 C are connected in parallel. With this arrangement, each of the conductive loops in the plurality of conductive loops 372 is electrically connected to the electronics 340 , the electronics 350 , and the sensor 360 via a first connection 374 and a second connection 376 . And the electronics 340 , the electronics 350 , and the sensor 360 are electrically connected via the first connection 374 and the second connection 376 .
- the first connection 374 and the second connection 376 may take the form of or be similar in form to the first connection 274 and the second connection 276 and/or the interconnects 151 and 157 .
- the conductive loops 372 A, 372 B, and 372 C are substantially concentric.
- the conductive loops 372 A, 372 B, and 372 C are spaced apart from each other between the outer diameter 332 and the inner diameter 334 .
- the conductive loops 372 A, 372 B, and 372 C may have a width that is the same or similar to a width of the conductive loops 272 A, 272 B, and 272 C.
- each of the conductive loops in the plurality of conductive loops 372 can comprise a respective metal layer disposed between respective polymer layers, like the conductive loops in the plurality of conductive loops 272 comprise a respective metal layer disposed between respective polymer layers.
- the plurality of conductive loops 372 can be formed like the plurality of conductive loops 272 is formed.
- the metal and polymer layers in each conductive loop in the plurality of conductive loops 372 are spaced apart from the metal and polymer layers in each adjacent conductive loop in the in the plurality of conductive loops 372 .
- the transparent polymer 320 can extend between adjacent conductive loops (e.g., the conductive loop 372 A and the conductive loop 372 B and/or the conductive loop 372 B and the conductive loop 372 C) in the plurality of conductive loops 372 .
- the metal and polymer layers of conductive loop 372 B are spaced apart from the metal and polymer layers of adjacent conductive loop 372 A by a first distance 394
- the metal and polymer layers of conductive loop 372 B are spaced apart from the metal and polymer layers of adjacent conductive loop 372 C by a second distance 396 .
- the first distance 394 and the second distance 396 can be between 100 to 200 micrometers. Other distances are possible as well.
- the first distance 394 could be a different value than the second distance 396 .
- the first distance 394 can be greater (or less) than the second distance 396 .
- the first distance 394 and/or the second distance 396 could vary.
- the first distance 394 can vary based on a rotational orientation of the conductive loop 372 B relative to the conductive loop 372 A and/or the conductive loop 372 C.
- the second distance 396 can vary based on a rotational orientation of the conductive loop 372 B relative to the conductive loop 372 C and/or the conductive loop 372 A.
- FIG. 3 c is a side cross-section view of the eye-mountable 310 while mounted to a corneal surface 384 of an eye 380 , according to an example embodiment.
- FIG. 3 d is a close-in side cross-section view enhanced to show tear film layers 390 , 392 surrounding exposed surfaces 324 , 326 of the eye-mountable device 310 , according to an example embodiment. It is noted that relative dimensions in FIGS. 3 c and 3 d are not necessarily to scale, but have been rendered for purposes of explanation only in describing the arrangement of the eye-mountable electronic device 310 .
- the total thickness of the eye-mountable device 310 can be about 200 micrometers, while the thickness of the tear film layers 390 , 392 can each be about 10 micrometers, although this ratio may not be reflected in the drawings. Some aspects are exaggerated to allow for illustration and facilitate explanation.
- the eye 380 includes a cornea 382 that is covered by bringing the upper eyelid 386 and lower eyelid 388 together over the top of the eye 380 .
- Incident light is received by the eye 380 through the cornea 382 , where light is optically directed to light-sensing elements of the eye 380 (e.g., rods and cones, etc.) to stimulate visual perception.
- the motion of the eyelids 386 , 388 distributes a tear film across the exposed corneal surface 384 of the eye 380 .
- the tear film is an aqueous solution secreted by the lacrimal gland to protect and lubricate the eye 380 .
- the tear film coats both the anterior and posterior sides 324 , 326 with an inner layer 390 (along the posterior side 326 ) and an outer layer 392 (along the anterior side 324 ).
- the tear film layers 390 , 392 can be about 10 micrometers in thickness and together account for about 10 microliters.
- the tear film layers 390 , 392 are distributed across the corneal surface 384 and/or the posterior side 324 by motion of the eyelids 386 , 388 .
- the eyelids 386 , 388 raise and lower, respectively, to spread a small volume of tear film across the corneal surface 384 and/or the anterior side 324 of the eye-mountable device 310 .
- the tear film layer 390 on the corneal surface 384 also facilitates mounting the eye-mountable device 310 by capillary forces between the anterior side 326 and the corneal surface 384 .
- the eye-mountable device 310 can also be held over the eye in part by vacuum forces against the corneal surface 384 due to the concave curvature of the eye-facing anterior side 326 .
- a polymer layer defining the anterior side 326 may be greater than 50 micrometers thick, whereas a polymer layer defining the posterior side 324 may be less than 150 micrometers.
- the sensor 360 when the sensor 360 is mounted on an outward-facing surface 335 (as shown in FIG. 3 d ) the sensor 360 may be at least 50 micrometers away from the anterior side 324 and may be a greater distance away from the posterior side 326 .
- the sensor 360 may be mounted on an inward-facing surface 333 of the structure 330 such that the sensor 360 is facing the posterior side 326 .
- the sensor 360 could also be positioned closer to the anterior side 324 than the posterior side 326 .
- the sensor 360 can receive analyte concentrations in the tear film 392 via a channel 373 .
- analyte concentrations in the tear film 390 and/or 392 may diffuse through the transparent polymer 320 to the sensor 360 .
- the eye-mountable device 310 might not include the channel 373 .
- body-mountable device has been described as comprising the eye-mountable device 110 and/or the eye-mountable device 310 , the body-mountable device could comprise other mountable devices that are mounted on or in other portions of the human body.
- the body-mountable device may comprise a tooth-mountable device.
- the tooth-mountable device may take the form of or be similar in form to the eye-mountable device 110 and/or the eye-mountable device 310 .
- the tooth-mountable device could include a polymeric material or a transparent polymer that is the same or similar to any of the polymeric materials or transparent polymers described herein and a substrate or a structure that is the same or similar to any of the substrates or structures described herein.
- the tooth-mountable device may be configured to detect at least one analyte in a fluid (e.g., saliva) of a user wearing the tooth-mountable device.
- a fluid e.g., saliva
- the body-mountable device may comprise a skin-mountable device.
- the skin-mountable device may take the form of or be similar in form to the eye-mountable device 110 and/or the eye-mountable device 310 .
- the skin-mountable device could include a polymeric material or a transparent polymer that is the same or similar to any of the polymeric materials or transparent polymers described herein and a substrate or a structure that is the same or similar to any of the substrates or structures described herein.
- the skin-mountable device may be configured to detect at least one analyte in a fluid (e.g., perspiration, blood, etc.) of a user wearing the skin-mountable device.
- a fluid e.g., perspiration, blood, etc.
- some embodiments may include privacy controls which may be automatically implemented or controlled by the wearer of a body-mountable device. For example, where a wearer's collected physiological parameter data and health state data are uploaded to a cloud computing network for trend analysis by a clinician, the data may be treated in one or more ways before it is stored or used, so that personally identifiable information is removed. For example, a user's identity may be treated so that no personally identifiable information can be determined for the user, or a user's geographic location may be generalized where location information is obtained (such as to a city, ZIP code, or state level), so that a particular location of a user cannot be determined.
- wearers of a body-mountable device may be provided with an opportunity to control whether or how the device collects information about the wearer (e.g., information about a user's medical history, social actions or activities, profession, a user's preferences, or a user's current location), or to control how such information may be used.
- the wearer may have control over how information is collected about him or her and used by a clinician or physician or other user of the data.
- a wearer may elect that data, such as health state and physiological parameters, collected from his or her device may only be used for generating an individual baseline and recommendations in response to collection and comparison of his or her own data and may not be used in generating a population baseline or for use in population correlation studies.
- FIG. 4 is a top view of a structure 430 , according to an example embodiment.
- the structure 430 includes a spacer 478 configured to maintain substantially uniform spacings between adjacent conductive loops in a plurality of conductive loops 472 .
- substantially uniform refers to exactly uniform and/or one or more deviations from exactly uniform that do not significantly impact embedding an structure in a body-mountable device as described herein.
- the structure 430 has an outer diameter 432 and an inner diameter 434 and includes electronics 440 , electronics 450 , a sensor 460 , and an antenna 470 disposed thereon.
- the outer diameter 432 may take the form of or be similar in form to the outer diameter 232 and/or the outer diameter 332 ;
- the inner diameter 434 may take the form of or be similar in form to the inner diameter 234 and/or the inner diameter 334 ;
- the electronics 440 may take the form of or be similar in form to the controller 150 , the electronics 240 , and/or the electronics 340 , the electronics 450 may take the form or be similar in form to the controller 150 , the electronics 250 , and/or the electronics 350 ;
- the sensor 460 may take the form or be similar in form to the bio-analyte sensor 162 , the sensor 260 , and/or the sensor 360 .
- the antenna 470 is configured for communications and/or harvesting energy, like the antenna 270 and the antenna 370 are configured for communications and/or harvesting energy.
- the antenna 470 includes the plurality of conductive loops 472 .
- the plurality of conductive loops 472 is spaced apart from each other between the outer diameter 432 and the inner diameter 434 .
- the plurality of conductive loops 472 includes three conductive loops 472 A, 472 B, and 472 C.
- a plurality of conductive loops may include more than three conductive loops, such as five conductive loops, nine conductive loops, etc.
- the conductive loops 472 A, 472 B, and 472 C can have an arrangement similar to an arrangement of the conductive loops 272 A, 272 B, and 272 C and/or the conductive loops 372 A, 372 B, and 372 C. As shown in FIG. 4 , the conductive loops 472 A, 472 B, and 472 C are connected in parallel. With this arrangement, each of the conductive loops in the plurality of conductive loops 472 is electrically connected to the electronics 440 , the electronics 450 , and the sensor 460 via a first connection 474 and a second connection 476 . And the electronics 440 , the electronics 450 , and the sensor 460 are electrically connected via the first connection 474 and the second connection 476 .
- the first connection 474 and the second connection 476 may take the form of or be similar in form to the interconnects 151 and 157 , the first connection 274 and the second connection 276 , and/or the first connection 374 and the second connection 376 .
- the conductive loops 472 A, 472 B, and 472 C are substantially concentric. And as shown in FIG. 4 , the conductive loops 472 A, 472 B, and 472 C are spaced apart from each other between the outer diameter 432 and the inner diameter 434 . In an example, the conductive loops 472 A, 472 B, and 472 C can be spaced apart from adjacent conductive loops by a distance between 100 to 200 micrometers. Other distances are possible as well.
- the conductive loops 472 A, 472 B, and 472 C may have a width that is the same or similar to a width of the conductive loops 272 A, 272 B, and 272 C and/or the conductive loops 372 A, 372 B, and 372 C.
- each of the conductive loops in the plurality of conductive loops 472 can comprise a respective metal layer disposed between respective polymer layers, like the conductive loops in the plurality of conductive loops 272 comprise a respective metal layer disposed between respective polymer layers.
- the plurality of conductive loops 472 can be formed like the plurality of conductive loops 272 and/or the plurality of conductive loops 372 is formed.
- the structure 430 may be embedded in a transparent polymer, such as the transparent polymer 320 .
- a transparent polymer such as the transparent polymer 320 .
- the metal and polymer layers in each conductive loop in the plurality of conductive loops 472 can be spaced apart from the metal and polymer layers in each adjacent conductive loop in the plurality of conductive loops 472 .
- the transparent polymer can extend between adjacent conductive loops in the plurality of conductive loops 472 .
- the structure 430 includes the spacer 478 .
- the conductive loops 472 A, 472 B, and 472 C may not move relative to each other based on the spacer 478 .
- the spacer 478 is connected to the conductive loops 472 A, 472 B, and 472 C and is located on the structure 430 substantially opposite of the sensor 260 .
- Other locations of the spacer 478 on the structure 430 are possible as well.
- the spacer 478 could be located on the structure 430 at a predetermined rotational orientation, such as 30 degrees, 45 degrees, 60 degrees, 90 degrees, etc.
- the spacer 478 could take various different forms in various different embodiments.
- the spacer 478 can have a width between 50 and 300 micrometers. Other widths of the spacer 478 are possible as well.
- the spacer 478 can comprise a metal, such as gold, platinum, palladium, titanium, aluminum, copper, and/or silver.
- the spacer 478 can comprise the same metal as the respective metal layers of the conductive loops 472 A, 472 B, and 472 C.
- the spacer 478 can comprise a different metal than the respective metal layers of the conductive loops 472 A, 472 B, and 472 C.
- the spacer 478 can be formed by a process that includes electroplating.
- the spacer 478 can comprise a polymeric material, such as PET or paralyene.
- the spacer 478 can comprise the same polymeric material as the respective polymer layers of the conductive loops 472 A, 472 B, and 472 C.
- the spacer 478 can comprise a different polymeric material than the respective polymer layers of the conductive loops 472 A, 472 B, and 472 C.
- the spacer 478 can be formed by a process that includes chemical vapor deposition.
- the spacer 478 can comprise a metal layer disposed between polymer layers, like the respective metal layers disposed between the respective polymer layers of the conductive loops 472 A, 472 B, and 472 C.
- the spacer 478 is formed by a process that includes etching a portion of a metal and/or a polymeric material with an inductively coupled plasma, such as an oxygen plasma.
- the structure 430 includes one spacer, the spacer 478 .
- a structure may include more than one spacer, such as two spacers, three spacers, four spacers, etc.
- a structure could include one or more spacers configured to maintain substantially uniform spacings between adjacent conductive loops in a plurality of conductive loops.
- each spacer in the one or more spacers could be located on the structure in a predetermined rotational orientation, such as 30 degrees, 45 degrees, 60 degrees, 90 degrees, etc.
- Each of the spacers in the one or more spacers could take the form or be similar in form to the spacer 478 .
- FIG. 5 is a top view of a structure 530 , according to an example embodiment.
- the structure 530 includes an antenna 570 that includes a plurality of conductive loops 572 that includes three conductive loops 572 A, 572 B, and 572 C. As shown in FIG. 5 , the conductive loops 572 A, 572 B, and 572 C are connected in series.
- the structure 530 has an outer diameter 532 , and an inner diameter 534 .
- the outer diameter 532 may take the form of or be similar in form to the outer diameter 232 , the outer diameter 332 , and/or the outer diameter 432 ; and the inner diameter 434 may take the form of or be similar in form to the inner diameter 234 , the inner diameter 334 , and or the inner diameter 434 .
- the structure 530 includes the antenna 570 .
- the antenna 570 is configured for communications and/or harvesting energy, like the antenna 270 , the antenna 370 , and the antenna 470 are configured for communications and/or harvesting energy.
- the antenna 570 includes the plurality of conductive loops 572 spaced apart from each other between the outer diameter 532 and the inner diameter 534 .
- the plurality of conductive loops 572 includes the conductive loops 572 A, 572 B, and 572 C.
- a plurality of conductive loops may include more than three conductive loops, such as five conductive loops, nine conductive loops, etc.
- the conductive loops 572 A, 572 B, and 572 C are connected in series.
- the conductive loop 572 A is electrically connected to an electrical component 555 via a first connection 574 and the conductive loop 572 C is electrically connected to the electrical component 555 via a second connection 576 .
- the electrical component 555 could include electronics (e.g., the controller 150 , the electronics 240 , the electronics 250 , the electronics 340 , the electronics 350 , the electronics 440 , and/or the electronics 450 ) and/or a sensor (e.g., the analyte bio-sensor 162 , the sensor 260 , the sensor 360 , and/or the sensor 460 ).
- the electrical component 555 includes more than one component, the more than one component could be arranged in series.
- the conductive loop 572 C is connected to the second connection via a bridge 573 .
- the bridge 573 may insulate the conductive loop 572 C from the conductive loop 572 B and/or the conductive loop 572 A.
- the bridge 573 can comprise a polymeric material, such as PET or paralyene.
- the bridge 573 can comprise the same polymeric material as the spacer 478 and/or the respective polymer layers of the conductive loops 272 A, 272 B, and 272 C, the conductive loops 372 A, 372 B, and 372 C, and/or the conductive loops 472 A, 472 B, and 472 C.
- the bridge 573 can comprise a different polymeric material than the spacer 478 and/or the respective polymer layers.
- the bridge 573 may be other materials as well, such as silicon.
- the bridge 573 may include an integrated circuit.
- the conductive loop 572 A, the conductive loop 572 B, and the conductive loop 572 C may cross at the bridge 573 .
- the plurality of conductive loops 572 is a continuous material arranged in multiple windings, shown as the conductive loops 572 A, 572 B, and 572 C.
- a plurality of conductive loops may not be a continuous material.
- the conductive loops 572 A, 572 B, and 572 C are substantially concentric. And as shown in FIG. 5 , the conductive loops 572 A, 572 B, and 572 C are spaced apart from each other between the outer diameter 532 and the inner diameter 534 . In an example, the conductive loops 572 A, 572 B, and 572 C are spaced apart from adjacent conductive loops by a distance between 100 to 200 micrometers. Other distances are possible as well.
- the conductive loops 572 A, 572 B, and 572 C may have a width that is the same or similar to a width of the conductive loops 272 A, 272 B, and 272 C; the conductive loops 372 A, 372 B, and 372 C; and/or the conductive loops 472 A, 472 B, and 472 C.
- each of the conductive loops in the plurality of conductive loops 572 can comprise a respective metal layer disposed between respective polymer layers, like the conductive loops in the plurality of conductive loops 272 comprise a respective metal layer disposed between respective polymer layers.
- the conductive loops 572 A, 572 B, and 572 C can be formed by a process that includes electroplating, chemical vapor deposition, and etching, using an inductively coupled plasma, such as oxygen plasma.
- the structure 530 may be embedded in a transparent polymer, like the structure 330 is embedded in the transparent polymer 320 .
- the conductive loops 572 A, 572 B, and 572 C may move relative to each other.
- movement of the conductive loops 572 A, 572 B, and 572 C may be the same as movement of the conductive loops 372 A, 372 B, and 372 C.
- movement of the conductive loops 572 A, 572 B, and 572 C may be greater (or less) than movement of the conductive loops 372 A, 372 B, and 372 C.
- each of the conductive loops in the plurality of conductive loops 572 comprise a respective metal layer disposed between respective polymer layers
- the metal and polymer layers in each conductive loop in the plurality of conductive loops 572 can be spaced apart from the metal and polymer layers in each adjacent conductive loop in the plurality of conductive loops 572 .
- the transparent polymer can extend between adjacent conductive loops in the plurality of conductive loops 572 .
- the metal and polymer layers of conductive loop 572 B can be spaced apart from the metal and polymer layers of adjacent conductive loop 572 A by a first distance, and the conductive loop 572 B may be spaced apart from the adjacent conductive loop 572 C by a second distance.
- the first and second distances can be between 100 to 200 micrometers. Other distances are possible as well.
- the first distance could be a different value than the second distance.
- the first distance can be greater (or less) than the second distance.
- the first distance and/or the second distance could vary.
- the first distance can vary based on a rotational orientation of the conductive loop 572 B and/or the conductive loop 572 C relative to the conductive loop 572 A.
- the second distance can vary based on a rotational orientation of the conductive loop 572 C and/or the conductive loop 572 A relative to the conductive loop 572 B.
- FIG. 6 is a flow chart illustrating a method, according to an example embodiment. More specifically, the method 600 involves forming a first polymer layer, as shown by block 602 . The method 600 may then involve positioning a structure on the first polymer layer, as shown by block 604 . Further, the method 600 may then involve conforming the structure positioned on the first polymer layer to a curvature of the first polymer layer, as shown by block 606 . The method 600 may then involve forming a second polymer layer over the first polymer layer and the structure, as shown by block 608 .
- method 600 is described below as being carried out by a fabrication device that utilizes cast or compression molding. It should be understood, however, that method 600 may be carried out by a fabrication device that utilizes other methods for forming the polymer layers.
- the method 600 is described below in a scenario where a body-mountable device comprises an eye-mountable device. It should be understood, however, that the method 600 may involve scenarios where the body-mountable device comprises other mountable devices that are mounted on or in other portions of the human body. For example, the method 600 may involve scenarios where the body-mountable device comprises a tooth-mountable device and/or a skin-mountable device as described herein.
- the fabrication device may be used to form a first polymer layer.
- the fabrication device may include molding pieces, such as molding pieces that are suitable for cast molding.
- FIG. 7 a illustrates a fabrication device 700 that includes example molding pieces that may be used to form the first polymer layer.
- FIG. 7 a illustrates a fabrication device 700 including a first molding piece 702 and a second molding piece 704 .
- the first molding piece 702 and the second molding piece 704 may define a first cavity.
- the second molding piece 704 may be filled with a polymer material 706 , and the polymer material 706 may be compressed into a first polymer layer 708 by the first molding piece 702 .
- the fabrication device 700 may cure the first polymer layer 708 .
- Curing involves the hardening of a polymer material by cross-linking of polymer chains, and curing may be, for example, brought about by chemical additives, ultraviolet radiation, electron beam, and/or heat.
- the polymer material 706 can be a light-curable polymer material, and the fabrication device 700 may be configured to cure the light-curable polymer material using light, such as ultraviolet light or visible light.
- the first polymer layer 708 may be cured to a partially-cured state. In an example, this may involve curing the material to a partially-cured state that is approximately 50-75% of a fully cured state. Other partially-cured states are possible as well. Beneficially, by partially curing the first polymer layer to a partially-cured state, the first polymer layer 708 may have a tackiness that facilitates adhesion thereto. With this arrangement, the tackiness may ensure that a structure conformed to a curvature of the first polymer layer 708 remains securely fixed in a given location during subsequent formation steps.
- the tackiness exhibited by the partially-cured first polymer layer 708 may be different for different polymers. Accordingly, the fabrication device 700 may be configured to cure different polymer materials differently than other polymer materials (e.g., a first polymer material may be cured more than a second polymer material). Further, in addition to light curing, other methods of curing are possible as well, such as chemical additives and/or heat. Yet still further, in other example embodiments, the first polymer layer may be completely cured. Alternatively, the fabrication device 700 may bypass the curing process at this stage.
- the first molding piece 702 and the second molding piece 704 may be configured to achieve a given desired thickness of the first polymer layer 708 .
- the first polymer layer 708 can have a thickness of less than 150 micrometers.
- the first molding piece 702 and the second molding piece 704 can be designed so as to allow for a layer having less than a 150 micrometer thickness between the two cavities. As such, when the first molding piece 702 and the second molding piece 704 are pressed together during the formation of the first polymer layer 708 , the resulting polymer layer 708 will have a thickness of less than 150 micrometers.
- the thickness of the first polymer layer 708 can be selected based on a particular analyte or analytes an eye-mountable device is configured to detect.
- an optimal thickness for a first analyte may be 10 micrometers, while an optimal thickness for a second analyte may be 25 micrometers. Other examples are possible as well.
- the polymer material 706 can be any material that can form an eye-compatible polymer layer.
- the polymer material 706 may be a formulation containing polymerizable monomers, such as hydrogels, silicone hydrogels, silicone elastomers, and rigid gas permeable materials.
- the polymer material 706 may form a transparent or substantially transparent polymer layer.
- the use of the polymer material 706 may result in an eye-mountable device through which the wearer can see when mounted on the wearer's eye.
- the polymer material 706 can be a hydrogel material, such as silicone hydrogel.
- hydrogel materials are commonly used in contact-lens technology and are well-suited for eye-mountable devices. Other materials are possible as well.
- first molding piece 702 and/or the second molding piece 704 can be configured so as to allow sufficient pinch off to provide for suitable edges for an eye-mountable device.
- the first polymer layer 708 defines a posterior side 710 of an eye-mountable device. That is, the first polymer layer 708 defines an outer edge of the eye-mountable device. When mounted on an eye of a user, the posterior side 710 of the eye-mountable device defined by the first polymer layer 708 corresponds to a side of the device touching the eye of the user.
- the first molding piece 702 may be shaped so as to define a shape of the posterior side 710 . For example, a curvature of the posterior side 710 may be defined by the first molding piece 702 .
- the second molding piece 704 may be shaped so as to define a shape of a positioning surface 711 of the first polymer layer.
- the second molding piece 704 may define a curvature of a positioning surface 711 of the first polymer layer 708 .
- a structure can be conformed to the curvature of the positioning surface 711 of the first polymer layer 708 .
- the first polymer layer 708 can further comprise an alignment feature 712 .
- the alignment feature 712 can comprise an asymmetric peg.
- the asymmetric peg can be a variety of shapes.
- the asymmetric peg can have a star-shaped or cross-shaped cross section. Other shapes of the asymmetric peg are possible as well.
- FIG. 7 a illustrates forming the first polymer layer 708 through cast molding
- the first polymer layer 708 may be formed via injection molding.
- injection molding rather than polymer material being compressed between molding pieces, molding material may be heated and injected or otherwise forced into a molding piece or pieces. The injected molding material may then cool and harden to the configuration of the molding piece or pieces.
- the first polymer layer 708 may be formed via spin casting.
- the fabrication device may form a first polymer layer of a precise thickness.
- a spin-casting mold may be spun along its central access at a set speed, and the polymer may be introduced to the mold as the mold is spinning in order to form a first polymer layer.
- the final thickness of the first polymer layer may be influenced by various factors, including but not limited to the spin-casting mold, the amount of polymer introduced to the spin-casting mold, properties of the polymer such as viscosity, and/or the speed at which the spin-casting mold is rotated. These factors may be varied in order to result in a first polymer layer of a well-defined thickness.
- FIGS. 7 b and 7 c illustrate an example in which a structure 730 is positioned on the first polymer layer 708 .
- the structure 730 has an outer diameter 732 and an inner diameter 734 and includes electronics 740 , electronics 750 , a sensor 760 , and an antenna 770 disposed thereon.
- the structure 730 may take the form of or be similar in form to the substrate 130 , the structure 230 , the structure 330 , the structure 430 and/or the structure 530 .
- the structure 730 can further include one or more spacers, such as the spacer 478 .
- the outer diameter 732 may take the form of or be similar in form to the outer diameter 232 , the outer diameter 332 , the outer diameter 432 , and/or the outer diameter 532 ;
- the inner diameter 734 may take the form of or be similar in form to the inner diameter 234 , the inner diameter 334 , and or the inner diameter 434 and/or the outer diameter 534 ;
- the electronics 740 may take the form or be similar in form to the controller 150 , the electronics 240 , the electronics 340 , the electronics 440 and/or the electronics 555 ;
- the electronics 750 may take the form of or be similar in form to the controller 150 , the electronics 250 , the electronics 350 , the electronics 450 , and/or the electronics 555 ;
- the sensor 760 may take the form of or be similar in form to the bio-analyte sensor 162 , the sensor 260 , the sensor 360 , the sensor 460 .
- the structure 730 includes the antenna 770 .
- the antenna 770 is configured for communications and/or harvesting energy, like the antenna 270 , the antenna 370 , the antenna 470 , and the antenna 570 are configured for communications and/or harvesting energy.
- the antenna 770 includes a plurality of conductive loops spaced 772 apart from each other between the outer diameter 732 and the inner diameter 734 .
- the plurality of conductive loops 772 includes three conductive loops 772 A, 772 B, and 772 C.
- a plurality of conductive loops may include more than three conductive loops, such as five conductive loops, nine conductive loops, etc.
- the conductive loops 772 A, 772 B, and 772 C are substantially concentric. And as shown in FIG. 7 b , the conductive loops 772 A, 772 B, and 772 C are spaced apart from each other between the outer diameter 732 and the inner diameter 734 . In an example, the conductive loops 772 A, 772 B, and 772 C are spaced apart from adjacent conductive loops by a distance between 100 to 200 micrometers. Other distances are possible as well. In the illustrated example, the conductive loops 772 A, 772 B, and 772 C are connected in parallel. However, in other examples, conductive loops can be connected in series, like the conductive loops 572 A, 572 B, and 572 C are connected in series.
- the fabrication device 700 may separate the first molding piece 702 from the second molding piece 704 .
- the first polymer layer 708 may stick to a side of the first molding piece 702 .
- the first polymer layer 708 and/or the first molding piece 702 can be surface treated, such that the first polymer layer 708 sticks to the side of the first molding piece 702 .
- the second molding piece 704 can be surface treated, such that the first polymer layer 708 sticks to the side of the first molding piece 702 .
- positioning the structure 730 on the first polymer layer 708 can include aligning the structure 730 with the alignment feature 712 .
- the inner diameter 734 can be asymmetric and the alignment feature 712 includes an asymmetric peg such that the inner diameter 734 receives the alignment feature 712 in only a predetermined rotational orientation (relative alignment between the alignment feature 712 and the inner diameter 734 in FIG. 7 c is not necessarily to scale).
- a predetermined rotational orientation of the structure 730 by alignment with the alignment feature 712 are also possible.
- the fabrication device 700 can include a positioning apparatus (not shown), such as a robotic system, configured to position the structure 730 on the first polymer layer 708 .
- the positioning apparatus may (i) pick up the structure 730 (e.g., via suction), (ii) position the structure 730 above the first polymer layer 708 , and then (iii) lower the structure 730 toward the first polymer layer 708 .
- the positioning apparatus may position the structure 730 in a predetermined rotational orientation.
- the positioning apparatus may then release the structure 730 (e.g., by releasing the suction).
- the first polymer layer 708 might not include the alignment feature 712 .
- the positioning apparatus may further include a vision system configured to assist with positioning the structure 730 on the first polymer layer 708 .
- a vision system may facilitate guiding the structure 730 to a precise location on the first polymer layer 708 .
- the vision system can be appropriate for situations in which one or more production specifications for an eye-mountable device, such as the eye-mountable device 310 , have requirements with very low tolerances related to the positioning of a sensor, such as the sensor 360 , within the eye-mountable device 310 .
- an eye-mountable device in accordance with an example embodiment allows for such repeatable and precise positioning.
- FIG. 7 c illustrates the structure 730 positioned on the first polymer layer 708 .
- the sensor 760 may be mounted at a particular angle along a circumference of the first polymer layer 708 .
- the sensor 760 may be placed at a precise location in an XYZ plane on the first polymer layer 708 .
- the sensor 760 may rest at a 6 o'clock position of the first polymer layer 708 .
- the sensor 760 may rest at a 12 o'clock position of the first polymer layer 708 .
- the structure positioned on the first polymer layer may be conformed to a curvature of the first polymer layer.
- FIG. 7 d illustrates an example in which the structure 730 is conformed to the curvature of the positioning surface 711 of the first polymer layer 708 .
- conforming the structure 730 to the curvature of the positioning surface 711 of the first polymer layer can include bending the structure 730 .
- the positioning apparatus may bend the structure 730 , such that the structure 730 conforms to the curvature of the positioning surface 711 of the first polymer layer 708 .
- the positioning apparatus may bend the structure 730 by applying a force and/or a torque to one or more portions of the structure 730 .
- other ways of conforming the structure 730 to the curvature of the positioning surface 711 are possible as well.
- the conductive loops 772 A, 772 B, and 772 C may move relative to each other. Beneficially, such movement can reduce buckling of the structure 730 when it is conformed to a curvature of the first polymer layer, such as the curvature of the positioning surface 711 of the first polymer layer 708 .
- An amount and/or type of movement of the conductive loops 772 A, 772 B, and 772 C may be based on a variety of parameters, such as a material, a width, a thickness, and/or a connection (e.g., parallel or series) of the conductive loops 772 A, 772 B, and 772 C and/or a material, a thickness, and a curvature of the first polymer layer 708 . Other parameters are possible as well. And in embodiments where the structure 730 further includes one or more spacers, such as the spacer 478 , the conductive loops 772 A, 772 B, and 772 C may not move relative to each other based on the one or more spacers.
- an eye-mountable device such as the eye-mountable device 310
- movement of the structure 730 during subsequent formation steps such as formation of a second polymer layer
- movement of the structure 730 during filling a mold piece with a polymeric material to form the second polymer layer and/or curing the second polymer layer can result in improper placement of the structure 730 relative to the surrounding polymer layers.
- an adhesive is applied to the structure 730 and/or the first polymer layer 708 before the structure 730 is positioned on the first polymer layer 708 .
- the applied adhesive may facilitate adhesion of the structure 730 to the first polymer layer 708 .
- a small amount of adhesive may be applied to a cured first polymer layer 708 , and the structure 730 may be conformed to a curvature of the first polymer layer 708 and then the adhesive may be cured such that the structure 730 adheres to the first polymer layer 708 .
- a small amount of adhesive may be applied to the structure 730 , and the structure 730 may then be conformed to a curvature of the first polymer layer 708 (e.g., a cured first polymer layer) and then the adhesive may be cured such that the structure 730 adheres to the first polymer layer 708 .
- the structure 730 may remain adhered to the first polymer layer 708 in a secure location during subsequent formation steps.
- a force and/or a torque can be applied to the structure 730 during curing of the adhesive.
- the first polymer layer 708 in a partially-cured state may have a tackiness that facilitates adhesion thereto.
- the structure 730 may remain adhered to the first polymer layer 708 in a secure location during subsequent formation steps.
- the fabrication device may form a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer and the second polymer layer.
- FIG. 7 e illustrates the fabrication device 700 including example molding pieces that may be used to form the second polymer layer.
- FIG. 7 e illustrates a third molding piece 722 .
- the first molding piece 702 and the third molding piece 722 may define a second cavity.
- the first molding piece 702 which already holds the first polymer layer 708 to which the structure 730 is mounted (as illustrated in FIG. 7 d ), may be filled with a polymer material 724 .
- the polymer material 724 may be formed into a second polymer layer 726 by compression between the first molding piece 702 and the third molding piece 722 .
- the second polymer layer 726 may mold over the structure 730 , such that the structure 730 is fully enclosed by the first polymer layer 708 and the second polymer layer 726 .
- the second polymer layer can extend between adjacent conductive loops, such as the conductive loop 772 A and the conductive loop 772 B and/or the conductive loop 772 B and the conductive loop 772 C, in the plurality of conductive loops 772 .
- the second polymer layer 726 may bond to the first polymer layer 708 between the adjacent conductive loops in the plurality of conductive loops 772 .
- the fabrication device 700 may cure the second polymer layer 726 .
- the second polymer layer 726 can be cured like the first polymer layer 708 .
- the second polymer layer 726 may be cured by different techniques than the first polymer layer 708 .
- the second polymer layer 726 can be cured by any of the techniques mentioned herein.
- the fabrication device 700 may cure the first polymer layer 708 at this stage.
- FIG. 3 a illustrates the eye-mountable device 310 .
- FIG. 3 a illustrates the eye-mountable device 300 includes the transparent polymer 320 .
- the transparent polymer 320 can be arranged like the first polymer layer 708 and the second polymer layer 726 .
- the fabrication device 700 may further comprise one or more alignment pins (not shown), such as a plurality of dowel pins, for aligning the third molding piece 722 and the first molding piece 702 .
- the one or more alignment pins can assist in forming the second polymer layer 726 by aligning the third molding piece 722 with the first molding piece 702 .
- the first molding piece 702 and the third molding piece 722 may be configured to achieve a given desired thickness of a layer formed between the two pieces.
- the first molding piece 702 and the third molding piece 722 may be designed so as to define a thickness of the second polymer layer 726 .
- the first molding piece 702 and the third molding piece 722 may be designed so as to define a final thickness of an eye-mountable device, such as the eye-mountable device 310 .
- the first molding piece 702 and the third molding piece 722 can be designed so as to allow for a layer having a given desired thickness between the two pieces (in addition to a thickness of the first polymer 708 ). As such, when the first molding piece 702 and the third molding piece 722 are pressed together during formation of a layer, the resulting layer will have the given desired thickness.
- the second polymer layer 726 has a thickness of greater than 50 micrometers. However, in other examples, the second polymer layer 726 can have a thickness between 50 and 300 micrometers, such as 130 micrometers. It should be understood that since the second polymer layer 726 molds over the structure 730 , the second polymer layer 726 may not have a uniform thickness. For instance, the thickness of the second polymer layer 726 above the sensor 760 may be less than the thickness of the second polymer layer 726 that is not touching the sensor 760 .
- the thickness of the second polymer layer 726 can be selected based on a particular analyte or analytes that the eye-mountable device, such as the eye-mountable device 310 , is configured to detect.
- a particular analyte or analytes that the eye-mountable device, such as the eye-mountable device 310 is configured to detect.
- an optimal thickness for a first analyte may be 10 micrometers, while an optimal thickness for a second analyte may be 25 micrometers. Other examples are possible as well.
- the second polymer layer 726 can be composed of the same polymer material as the first polymer layer 708 . However, in other examples, the second polymer layer 726 can be composed of a different polymer material than the first polymer layer 708 .
- the second polymer layer 726 can be any one of the polymer materials mentioned herein.
- the structure 730 can be more rigid than the second polymer layer 726 .
- the second polymer layer 726 defines an anterior side 728 of an eye-mountable device. That is, the second polymer layer 726 defines an outer edge of the eye-mountable device.
- the anterior side 728 of the eye-mountable device defined by the second polymer layer 726 corresponds to the side of the device that is not touching the eye of the user.
- the third molding piece 722 may be shaped so as to define a shape of the anterior side 728 . For example, a curvature of the anterior side 728 may be defined by the third molding piece 722 .
- the example methods described above involve a method of fabricating an eye-mountable device that involves first forming a first polymer layer and subsequently forming a second polymer layer.
- the first polymer layer defining a posterior side of the eye-mountable device and the second polymer layer defining an anterior side of the eye-mountable device may be substantially formed around a structure, such as the structure 730 , at the same time.
- the fabrication device may be configured to position a structure within a molding cavity or cavities, and the fabrication device may then form the first polymer layer and the second polymer layer around the structure.
- the fabrication device may be configured to inject mold into the molding cavity, and the injected mold may encapsulate the structure.
- the fabrication device may include a molding cavity or cavities that have at least one opening configured to allow the fabrication device to hold the structure in place as the first and second polymer layers are formed around the structure.
- the molding cavity or cavities may be filled with the polymer material, and this introduction of the polymer material may form the polymer layers around the structure.
- the example methods described above may further include forming a channel through a second polymer layer, such that a sensor (e.g., sensor 760 ), is configured to receive one or more analytes via the channel.
- the channel may be formed by removing material from the second polymer layer.
- the material from the second polymer layer can be removed to form the channel in a variety of ways. For instance, the material from the second polymer layer can be removed to form the channel via a process that includes drilling, ablation, etching, etc.
- a mask layer may be formed before forming the second polymer layer. Further, in such an example, after the second polymer layer is formed, the mask layer may be removed to form a channel.
- the mask layer can be removed to form the channel in a variety of ways. For instance, the mask layer can be removed to form the channel via a process that includes etching the mask layer and/or dissolving the mask layer in a fluid.
- Some embodiments may include privacy controls.
- privacy controls may include, at least, anonymization of device identifiers, transparency and user controls, including functionality that would enable users to modify or delete information relating to the user's use of a product.
- the users may be provided with an opportunity to control whether programs or features collect user information (e.g., information about a user's medical history, social network, social actions or activities, profession, a user's preferences, or a user's current location), or to control whether and/or how to receive content from the content server that may be more relevant to the user.
- user information e.g., information about a user's medical history, social network, social actions or activities, profession, a user's preferences, or a user's current location
- certain data may be treated in one or more ways before it is stored or used, so that personally identifiable information is removed.
- a user's identity may be treated so that no personally identifiable information can be determined for the user, or a user's geographic location may be generalized where location information is obtained (such as to a city, ZIP code, or state level), so that a particular location of a user cannot be determined.
- location information such as to a city, ZIP code, or state level
- the user may have control over how information is collected about the user and used by a content server.
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Abstract
Description
- Unless otherwise indicated herein, the materials described in this section are not prior art to the claims in this application and are not admitted to be prior art by inclusion in this section.
- A body-mountable device may be configured to monitor health-related information based on at least one analyte detected in a fluid of a user wearing the body-mountable device. For example, the body-mountable device may comprise an eye-mountable device that may be in the form of a contact lens that includes a sensor configured to detect the at least one analyte (e.g., glucose) in a tear film of a user wearing the eye-mountable device. The body-mountable device may also be configured to monitor various other types of health-related information.
- In one aspect, a body-mountable device is disclosed. An example body-mountable device includes: a transparent polymer, wherein the transparent polymer defines a posterior side and an anterior side of the body-mountable device; and a structure embedded in the transparent polymer, wherein the structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna, wherein the antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter.
- In another aspect, a method involves: forming a first polymer layer, such that the first polymer layer has a curvature, wherein the first polymer layer defines a posterior side of a body-mountable device; positioning a structure on the first polymer layer, wherein the structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna, and wherein the antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter; conforming the structure positioned on the first polymer layer to the curvature of the first polymer layer; and forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer and the second polymer layer, wherein the second polymer layer defines an anterior side of the body-mountable device.
- In yet another aspect, a system is disclosed. A system includes means for forming a first polymer layer, such that the first polymer layer has a curvature, wherein the first polymer layer defines a posterior side of a body-mountable device; means for positioning a structure on the first polymer layer, wherein the structure has an outer diameter and an inner diameter and includes a sensor configured to detect an analyte and an antenna, and wherein the antenna includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter; means for conforming the structure positioned on the first polymer layer to the curvature of the first polymer layer; and means for forming a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer and the second polymer layer, wherein the second polymer layer defines an anterior side of the body-mountable device.
- These as well as other aspects, advantages, and alternatives, will become apparent to those of ordinary skill in the art by reading the following detailed description, with reference where appropriate to the accompanying drawings.
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FIG. 1 is a block diagram of a system that includes an eye-mountable device in wireless communication with an external reader, according to an example embodiment. -
FIG. 2 a is a top view of a structure, according to an example embodiment. -
FIG. 2 b is a side cross-section view of the structure shown inFIG. 2 a, according to an example embodiment. -
FIG. 3 a is a top view of an eye-mountable device, according to an example embodiment. -
FIG. 3 b is a side view of the eye-mountable device shown inFIG. 3 a, according to an example embodiment. -
FIG. 3 c is a side cross-section view of the eye-mountable device shown inFIG. 3 a while mounted to a corneal surface of an eye, according to an example embodiment. -
FIG. 3 d is a side cross-section view showing tear film layers surrounding the surfaces of the eye-mountable device mounted as shown inFIG. 3 c, according to an example embodiment. -
FIG. 4 is a top view of another structure, according to an example embodiment. -
FIG. 5 is a top view of yet another structure, according to an example embodiment. -
FIG. 6 is a flow chart illustrating a method, according to an example embodiment. -
FIG. 7 a is an illustration of formation of a first polymer layer, according to an example embodiment. -
FIG. 7 b is an illustration of positioning a structure on a first polymer layer, according to an example embodiment. -
FIG. 7 c is an illustration of a structure positioned on a first polymer layer, according to an example embodiment. -
FIG. 7 d is an illustration of conforming a structure positioned on a first polymer layer to a curvature of the first polymer layer, according to an example embodiment. -
FIG. 7 e is an illustration of formation of a second polymer layer, according to an example embodiment. - The following detailed description describes various features and functions of the disclosed systems and methods with reference to the accompanying figures. In the figures, similar symbols typically identify similar components, unless context dictates otherwise. The illustrative system and method embodiments described herein are not meant to be limiting. It will be readily understood that certain aspects of the disclosed systems and methods can be arranged and combined in a wide variety of different configurations, all of which are contemplated herein.
- A body-mountable device may include a transparent polymer and a structure embedded in the transparent polymer that has an outer diameter and an inner diameter. The transparent polymer defines a posterior side and an anterior side of the body-mountable device. The structure includes a sensor configured to detect an analyte and an antenna that includes a plurality of conductive loops spaced apart from each other between the outer diameter and the inner diameter. Beneficially, the plurality of conductive loops can reduce buckling of the structure (e.g., one or more protrusions from a surface of the structure) when it is bent to conform to a curvature of the transparent polymer.
- As used throughout this disclosure, the anterior side of the body-mountable device refers to an outward-facing side of the body-mountable device, whereas the posterior side of the body-mountable device refers to an inward-facing side of the body-mountable device. In particular, when the body-mountable device comprises an eye-mountable device and the eye-mountable device is mounted on an eye of the user, the anterior side corresponds to a side of the eye-mountable device that is facing outward and thus not touching the eye of the user. Further, when the eye-mountable device is mounted on an eye of the user, the posterior side corresponds to a side of the eye-mountable device that is facing inward and thus touching the eye of the user.
- A body-mountable device may be configured to monitor health-related information based on at least one analyte detected in a fluid of a user wearing the body-mountable device. An example body-mountable device that comprises an eye-mountable device that is configured to detect the at least one analyte in a tear film of a user wearing the eye-mountable device will now be described in greater detail.
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FIG. 1 is a block diagram of asystem 100 with an eye-mountable device 110 in wireless communication with anexternal reader 180, according to an example embodiment. The exposed regions of the eye-mountable device 110 are made of apolymeric material 120 formed to be contact-mounted to a corneal surface of an eye. In accordance with exemplary methods, thepolymeric material 120 may comprise a first polymer layer and a second polymer layer. -
Substrate 130 is embedded in thepolymeric material 120 to provide a mounting surface for apower supply 140, acontroller 150,bio-interactive electronics 160, and anantenna 170. Thebio-interactive electronics 160 are operated by thecontroller 150. Thepower supply 140 supplies operating voltages to thecontroller 150 and/or thebio-interactive electronics 160. Theantenna 170 is operated by thecontroller 150 to communicate information to and/or from the eye-mountable device 110. Theantenna 170, thecontroller 150, thepower supply 140, and thebio-interactive electronics 160 can all be situated on the embeddedsubstrate 130. Because the eye-mountable device 110 includes electronics and is configured to be contact-mounted to an eye, it may also be referred to as an ophthalmic electronics platform. - To facilitate contact-mounting, the
polymeric material 120 can have a concave surface configured to adhere (“mount”) to a moistened corneal surface (e.g., by capillary forces with a tear film coating the corneal surface). Additionally or alternatively, the eye-mountable device 110 can be adhered by a vacuum force between the corneal surface and the polymeric material due to the concave curvature. While mounted with the concave surface against the eye, the anterior or outward-facing surface of thepolymeric material 120 can have a convex curvature that is formed to not interfere with eye-lid motion while the eye-mountable device 110 is mounted to the eye. For example, thepolymeric material 120 can be a substantially transparent curved polymeric disk shaped similarly to a contact lens. - The
polymeric material 120 can include one or more bio-compatible materials, such as those employed for use in contact lenses or other ophthalmic applications involving direct contact with the corneal surface. Thepolymeric material 120 can optionally be formed in part from such bio-compatible materials or can include an outer coating with such bio-compatible materials. Thepolymeric material 120 can include materials configured to moisturize the corneal surface, such as hydrogels and the like. In some instances, thepolymeric material 120 can be a deformable (“non-rigid”) material to enhance wearer comfort. In some instances, thepolymeric material 120 can be shaped to provide a predetermined, vision-correcting optical power, such as can be provided by a contact lens. - The
substrate 130 includes one or more surfaces suitable for mounting thebio-interactive electronics 160, thecontroller 150, thepower supply 140, and theantenna 170. Thesubstrate 130 can be employed both as a mounting platform for chip-based circuitry (e.g., by flip-chip mounting) and/or as a platform for patterning conductive materials (e.g., gold, platinum, palladium, titanium, copper, aluminum, silver, metals, other conductive materials, combinations of these, etc.) to create electrodes, interconnects, antennae, etc. In some embodiments, substantially transparent conductive materials (e.g., indium tin oxide) can be patterned on thesubstrate 130 to form circuitry, electrodes, etc. For example, theantenna 170 can be formed by depositing a pattern of gold or another conductive material on thesubstrate 130. Similarly, interconnects 151, 157 between thecontroller 150 and thebio-interactive electronics 160, and between thecontroller 150 and theantenna 170, respectively, can be formed by depositing suitable patterns of conductive materials on thesubstrate 130. A combination of resists, masks, and deposition techniques can be employed to pattern materials on thesubstrate 130. - The
substrate 130 can be a relatively rigid polymeric material, such as polyethylene terephthalate (“PET”), paralyene, or another material sufficient to structurally support the circuitry and/or electronics within thepolymeric material 120. The eye-mountable device 110 can alternatively be arranged with a group of unconnected substrates rather than a single substrate. For example, thecontroller 150 and a bio-sensor or other bio-interactive electronic component can be mounted to one substrate, while theantenna 170 is mounted to another substrate and the two can be electrically connected via theinterconnects 157. - In some embodiments, the bio-interactive electronics 160 (and the substrate 130) can be positioned away from a center of the eye-
mountable device 110 and thereby avoid interference with light transmission to the eye through the center of the eye-mountable device 110. For example, where the eye-mountable device 110 is shaped as a concave-curved disk, thesubstrate 130 can be embedded around the periphery (e.g., near the outer circumference) of the disk. In some embodiments, the bio-interactive electronics 160 (and the substrate 130) can be positioned in a center region of the eye-mountable device 110. Thebio-interactive electronics 160 and/or thesubstrate 130 can be substantially transparent to incoming visible light to mitigate interference with light transmission to the eye. Moreover, in some embodiments, thebio-interactive electronics 160 can include apixel array 164 that emits and/or transmits light to be perceived by the eye according to display driver instructions. Thus, thebio-interactive electronics 160 can optionally be positioned in the center of the eye-mountable device so as to generate perceivable visual cues to a wearer of the eye-mountable device 110, such as by displaying information via thepixel array 164. - The
substrate 130 can be shaped as a flattened ring with a radial width dimension sufficient to provide a mounting platform for the embedded electronics components. Thesubstrate 130 can have a thickness sufficiently small to allow thesubstrate 130 to be embedded in thepolymeric material 120 without influencing the profile of the eye-mountable device 110. Thesubstrate 130 can have a thickness sufficiently large to provide structural stability suitable for supporting the electronics mounted thereon. For example, thesubstrate 130 can be shaped as a ring with a 1 centimeter diameter, a radial thickness of approximately 1 millimeter, and a thickness of about 50 micrometers. Thesubstrate 130 can optionally be aligned with the curvature of the anterior side of the eye-mountable device 110. - The
power supply 140 is configured to harvest ambient energy to power thecontroller 150 and thebio-interactive electronics 160. For example, a radio-frequencyenergy harvesting antenna 142 can capture energy from incident radio radiation. Additionally or alternatively, solar cell(s) 144 (“photovoltaic cells”) can capture energy from incoming ultraviolet, visible, and/or infrared radiation. Furthermore, an inertial power scavenging system (not shown) can be included to capture energy from ambient vibrations. The energy-harvestingantenna 142 can optionally be a dual-purpose antenna that is also used to communicate information to theexternal reader 180. That is, the functions of theantenna 170 and theenergy harvesting antenna 142 can be accomplished with the same physical antenna. - A rectifier/
regulator 146 can be used to condition the captured energy to a stableDC supply voltage 141 that is supplied to thecontroller 150. For example, theenergy harvesting antenna 142 can receive incident radio frequency radiation. Varying electrical signals on the leads of theenergy harvesting antenna 142 are output to the rectifier/regulator 146. The rectifier/regulator 146 rectifies the varying electrical signals to a DC voltage and regulates the rectified DC voltage to a level suitable for operating thecontroller 150. Additionally or alternatively, output voltage from the solar cell(s) 144 can be regulated to a level suitable for operating thecontroller 150. The rectifier/regulator 146 can include one or more energy storage devices arranged to mitigate high frequency variations in the ambientenergy harvesting antenna 142 and/or solar cell(s) 144. For example, an energy storage device (e.g., capacitor, inductor, etc.) can be connected to the output of the rectifier/regulator 146 so as to function as a low-pass filter. - The
controller 150 is turned on when theDC supply voltage 141 is provided to thecontroller 150, and the logic in thecontroller 150 operates thebio-interactive electronics 160 and theantenna 170. Thecontroller 150 can include logic circuitry configured to operate thebio-interactive electronics 160 so as to interact with a biological environment of the eye-mountable device 110. The interaction could involve the use of one or more components, such as ananalyte bio-sensor 162, inbio-interactive electronics 160 to obtain input from the biological environment. Alternatively or additionally, the interaction could involve the use of one or more components, such as thepixel array 164, to provide an output to the biological environment. - In one example, a
sensor interface module 152 can be included for operating theanalyte bio-sensor 162. Theanalyte bio-sensor 162 can be, for example, an amperometric electrochemical sensor that includes a working electrode and a reference electrode. Application of an appropriate voltage between the working and reference electrodes can cause an analyte to undergo electrochemical reactions (e.g., reduction and/or oxidation reactions) at the working electrode to generate an amperometric current. The amperometric current can be dependent on the analyte concentration, and thus the amount of amperometric current can provide an indication of analyte concentration. In some embodiments, thesensor interface module 152 can be a potentiostat configured to apply a voltage difference between the working and reference electrodes while measuring a current through the working electrode. - In some embodiments, at least a portion of the
bio-interactive electronics 160, thecontroller 150, the power supply, and/or theantenna 170 can be embedded in thesubstrate 130. And, in some embodiments, at least a portion of the bio-interactive electronics 160 (e.g., the analyte bio-sensor 162) can be surrounded by thesubstrate 130, except for a surface of the at least a portion of thebio-interactive electronics 160 being exposed by an opening in thesubstrate 130. - In some instances, a reagent can also be included to sensitize the electrochemical sensor to desired analytes. For example, a layer of glucose oxidase (“GOD”) can be situated around the working electrode to catalyze glucose into hydrogen peroxide (H2O2). The hydrogen peroxide can then be oxidized at the working electrode, which releases electrons to the working electrode, which generates a current.
- The current generated by either reduction or oxidation reactions can be approximately proportionate to the reaction rate. Further, the reaction rate can be dependent on the rate of analyte molecules reaching the electrochemical sensor electrodes to fuel the reduction or oxidation reactions, either directly or catalytically through a reagent. In a steady state, where analyte molecules flow and/or diffuse to the electrochemical sensor electrodes from a sampled region at approximately the same rate that additional analyte molecules diffuse to the sampled region from surrounding regions, the reaction rate can be approximately proportionate to the concentration of the analyte molecules. The current can thus provide an indication of the analyte concentration.
- The
controller 150 can optionally include adisplay driver module 154 for operating apixel array 164. Thepixel array 164 can be an array of separately programmable light transmitting, light reflecting, and/or light emitting pixels arranged in rows and columns. The individual pixel circuits can optionally include liquid crystal technologies, microelectromechanical technologies, emissive diode technologies, etc. to selectively transmit, reflect, and/or emit light according to information from thedisplay driver module 154. Such apixel array 164 can also optionally include more than one color of pixels (e.g., red, green, and blue pixels) to render visual content in color. Thedisplay driver module 154 can include, for example, one or more data lines providing programming information to the separately programmed pixels in thepixel array 164 and one or more addressing lines for setting groups of pixels to receive such programming information. Such apixel array 164 situated on the eye can also include one or more lenses to direct light from the pixel array to a focal plane perceivable by the eye. - The
controller 150 can also include acommunication circuit 156 for sending and/or receiving information via theantenna 170. Thecommunication circuit 156 can optionally include one or more oscillators, mixers, frequency injectors, etc. to modulate and/or demodulate information on a carrier frequency to be transmitted and/or received by theantenna 170. In some examples, the eye-mountable device 110 is configured to indicate an output from a bio-sensor by modulating an impedance of theantenna 170 in a manner that is perceivable by theexternal reader 180. For example, thecommunication circuit 156 can cause variations in the amplitude, phase, and/or frequency of backscatter radiation from theantenna 170, and such variations can be detected by theexternal reader 180. - The
controller 150 is connected to thebio-interactive electronics 160 viainterconnects 151. For example, where thecontroller 150 includes logic elements implemented in an integrated circuit to form thesensor interface module 152 and/ordisplay driver module 154, a patterned conductive material (e.g., gold, platinum, palladium, titanium, copper, aluminum, silver, metals, combinations of these, etc.) can connect a terminal on the chip to thebio-interactive electronics 160. Similarly, thecontroller 150 is connected to theantenna 170 viainterconnects 157. - It is noted that the block diagram shown in
FIG. 1 is described in connection with functional modules for convenience in description. However, embodiments of the eye-mountable device 110 can be arranged with one or more of the functional modules (“sub-systems”) implemented in a single chip, integrated circuit, and/or physical feature. For example, while the rectifier/regulator 146 is illustrated in thepower supply block 140, the rectifier/regulator 146 can be implemented in a chip that also includes the logic elements of thecontroller 150 and/or other features of the embedded electronics in the eye-mountable device 110. Thus, theDC supply voltage 141 that is provided to thecontroller 150 from thepower supply 140 can be a supply voltage that is provided on a chip by rectifier and/or regulator components the same chip. That is, the functional blocks inFIG. 1 shown as thepower supply block 140 andcontroller block 150 need not be implemented as separated modules. Moreover, one or more of the functional modules described inFIG. 1 can be implemented by separately packaged chips electrically connected to one another. - Additionally or alternatively, the
energy harvesting antenna 142 and theantenna 170 can be implemented with the same physical antenna. For example, a loop antenna can both harvest incident radiation for power generation and communicate information via backscatter radiation. - The
external reader 180 includes an antenna 188 (or group of more than one antennae) to send and receivewireless signals 171 to and from the eye-mountable device 110. Theexternal reader 180 also includes a computing system with aprocessor 186 in communication with amemory 182. Thememory 182 is a non-transitory computer-readable medium that can include, without limitation, magnetic disks, optical disks, organic memory, and/or any other volatile (e.g., RAM) or non-volatile (e.g., ROM) storage system readable by theprocessor 186. Thememory 182 can include adata storage 183 to store indications of data substrates, such as sensor readings (e.g., from the analyte bio-sensor 162), program settings (e.g., to adjust behavior of the eye-mountable device 110 and/or external reader 180), etc. The memory can also includeprogram instructions 184 for execution by theprocessor 186 to cause the external reader to perform processes specified by theprogram instructions 184. For example, theprogram instructions 184 can causeexternal reader 180 to provide a user interface that allows for retrieving information communicated from the eye-mountable device 110 (e.g., sensor outputs from the analyte bio-sensor 162). Theexternal reader 180 can also include one or more hardware components for operating theantenna 188 to send and receive the wireless signals 171 to and from the eye-mountable device 110. For example, oscillators, frequency injectors, encoders, decoders, amplifiers, filters, etc. can drive theantenna 188 according to instructions from theprocessor 186. - The
external reader 180 can be a smart phone, digital assistant, or other portable computing device with wireless connectivity sufficient to provide thewireless communication link 171. Theexternal reader 180 can also be implemented as an antenna module that can be plugged into a portable computing device, such as in an example where thecommunication link 171 operates at carrier frequencies not commonly employed in portable computing devices. In some instances, theexternal reader 180 is a special-purpose device configured to be worn relatively near a wearer's eye to allow thewireless communication link 171 to operate with a low power budget. For example, theexternal reader 180 can be integrated in a piece of jewelry such as a necklace, earing, etc. or integrated in an article of clothing worn near the head, such as a hat, headband, etc. - In an example where the eye-
mountable device 110 includes ananalyte bio-sensor 162, thesystem 100 can be operated to monitor the analyte concentration in tear film on the surface of the eye. Thus, the eye-mountable device 110 can be configured as a platform for an ophthalmic analyte bio-sensor. The tear film is an aqueous layer secreted from the lacrimal gland to coat the eye. The tear film is in contact with the blood supply through capillaries in the substrate of the eye and includes many biomarkers found in blood that are analyzed to characterize a person's health condition(s). For example, the tear film includes glucose, calcium, sodium, cholesterol, potassium, other biomarkers, etc. The biomarker concentrations in the tear film can be systematically different than the corresponding concentrations of the biomarkers in the blood, but a relationship between the two concentration levels can be established to map tear film biomarker concentration values to blood concentration levels. For example, the tear film concentration of glucose can be established (e.g., empirically determined) to be approximately one tenth the corresponding blood glucose concentration. Thus, measuring tear film analyte concentration levels provides a non-invasive technique for monitoring biomarker levels in comparison to blood sampling techniques performed by lancing a volume of blood to be analyzed outside a person's body. Moreover, the ophthalmic analyte bio-sensor platform disclosed here can be operated substantially continuously to enable real time monitoring of analyte concentrations. - To perform a reading with the
system 100 configured as a tear film analyte monitor, theexternal reader 180 can emitradio frequency radiation 171 that is harvested to power the eye-mountable device 110 via thepower supply 140. Radio frequency electrical signals captured by the energy harvesting antenna 142 (and/or the antenna 170) are rectified and/or regulated in the rectifier/regulator 146 and a regulated DC supply voltage 647 is provided to thecontroller 150. Theradio frequency radiation 171 thus turns on the electronic components within the eye-mountable device 110. Once turned on, thecontroller 150 operates theanalyte bio-sensor 162 to measure an analyte concentration level. For example, thesensor interface module 152 can apply a voltage between a working electrode and a reference electrode in theanalyte bio-sensor 162 sufficient to cause the analyte to undergo an electrochemical reaction at the working electrode. The current through the working electrode can be measured to provide the sensor output indicative of the analyte concentration. Thecontroller 150 can operate theantenna 170 to communicate the sensor results back to the external reader 180 (e.g., via the communication circuit 156). The sensor result can be communicated by, for example, modulating an impedance of theantenna 170 such that the modulation in impedance is detected by theexternal reader 180. The modulation in antenna impedance can be detected by, for example, backscatter radiation from theantenna 170. - In some embodiments, the
system 100 can operate to non-continuously (“intermittently”) supply energy to the eye-mountable device 110 to power the on-board controller 150 and thebio-interactive electronics 160. For example,radio frequency radiation 171 can be supplied to power the eye-mountable device 110 long enough to carry out a tear film analyte concentration measurement and communicate the results. For example, the supplied radio frequency radiation can provide sufficient power to charge two electrodes to a potential sufficient to induce electrochemical reactions, measure the resulting amperometric current, and modulate the antenna impedance to adjust the backscatter radiation in a manner indicative of the measured current. In such an example, the suppliedradio frequency radiation 171 can be considered an interrogation signal from theexternal reader 180 to the eye-mountable device 110 to request a measurement. By periodically interrogating the eye-mountable device 110 (e.g., by supplyingradio frequency radiation 171 to temporarily turn the device on) and storing the sensor results (e.g., via the data storage 183), theexternal reader 180 can accumulate a set of analyte concentration measurements over time without continuously powering the eye-mountable device 110. -
FIG. 2 a is a top view of astructure 230, according to an example embodiment. In particular, thestructure 230 has anouter diameter 232 and aninner diameter 234 and includeselectronics 240,electronics 250, asensor 260, and anantenna 270 disposed thereon. Thestructure 230 may take the form of or be similar in form to thesubstrate 130. - The
structure 230 can have various sizes. For instance, the size of thestructure 230 may depend on which analyte an eye-mountable device is configured to detect. In an example, thestructure 230 has a maximum height of approximately 50 between 150 micrometers. Of course, other maximum heights of thestructure 230 are possible as well. - In an example, the
structure 230 has a height dimension of at least 50 micrometers. In other words, at some point of thestructure 230, the height of thestructure 230 may be at least 50 micrometers. In an example, this height dimension may correspond to a maximum height of thestructure 230. In accordance with the present disclosure, the maximum height of thestructure 230 corresponds to the height of thestructure 230 at its highest point. For instance, in the example where thestructure 230 comprises thesensor 260 and theelectronics 250, the height of thestructure 230 may vary (and thus thestructure 230 may have various height dimensions). For example, the height of thestructure 230 may be higher at a point where theelectronics 250 is mounted on thestructure 230, whereas the height may be lower at a point where there is no chip on thestructure 230. In such an example, the maximum height may correspond to the point where theelectronics 250 is mounted on thestructure 230. - The
outer diameter 232 and theinner diameter 234 could take various different forms in various different embodiments. In some embodiments, the outer diameter can have a length between 12.5 and 15 millimeters. Moreover, in some embodiments, the inner diameter can have a length greater than 8 millimeters. And other lengths of theouter diameter 232 and/orinner diameter 234 are possible as well. - The
electronics electronics 240 and/or theelectronics 250 may be configured to operate thesensor 260 and theantenna 270. And, in such an example, theelectronics 240 and/or theelectronics 250 may be configured for wireless communication with an external reader, such as theexternal reader 180. In some embodiments, theelectronics 240 and theelectronics 250 may provide a bias voltage for thesensor 260 and adjust backscattered radio frequency (RF) that is proportional to a current that is passing through thesensor 260. - The
electronics 240 and theelectronics 250 could take various different forms in various different embodiments. In some embodiments, theelectronics 240 and/or theelectronics 250 can comprise a chip including one or more logical elements. Theelectronics 240 and/or theelectronics 250 may take the form of or be similar in form to thecontroller 150. - The
sensor 260 is configured to detect one or more analytes. Thesensor 260 could take various different forms in various different embodiments. In some embodiments, thesensor 260 can comprise a pair of electrodes, such as a working electrode and a reference electrode. Thesensor 260 may take the form of or be similar in form to theanalyte bio-sensor 162. - The
antenna 270 is configured for communications and/or harvesting energy as described herein. Theantenna 270 includes a plurality ofconductive loops 272 spaced apart from each other between theouter diameter 232 and theinner diameter 234. In the illustrated example, the plurality ofconductive loops 272 includes threeconductive loops - As shown in
FIG. 2 a, theconductive loops conductive loops 272 is electrically connected to theelectronics 240, theelectronics 250, and thesensor 260 via afirst connection 274 and asecond connection 276. And theelectronics 240, theelectronics 250, and thesensor 260 are electrically connected via thefirst connection 274 and thesecond connection 276. Thefirst connection 274 and thesecond connection 276 may take the form of or be similar in form to theinterconnects FIG. 2 a, theconductive loops - And as shown in
FIG. 2 a, theconductive loops outer diameter 232 and theinner diameter 234. In an example, theconductive loops - In some embodiments, one of the
conductive loops conductive loops conductive loops conductive loops conductive loops - Each conductive loop in the plurality of
conductive loops 272 can comprise a respective metal layer disposed between respective polymer layers. With this arrangement, the polymer layers might block moisture from the metal layer.FIG. 2 b is a side cross-section view of the structure shown inFIG. 2 a, according to an example embodiment. As shown inFIG. 2 b, theconductive loop 272A comprises ametal layer 280 disposed betweenpolymer layers 282A and 282B. The respective metal layers of theconductive loops 272B and 272C may take the form of or be similar in form to the to themetal layer 280, and the respective polymer layers of theconductive loops 272B and 272C may take the form of or be similar in form to the polymer layers 282A and 282B. - In some embodiments, the
metal layer 280 can comprise gold or another conductive material that can be deposited on thestructure 230, such as platinum, palladium, titanium, carbon, aluminum, copper, silver, and/or silver-chloride. And in at least one such embodiment, themetal layer 280 can have a thickness between 5 and 30 micrometers. Other thicknesses of themetal layer 280 are possible as well. In an example, themetal layer 280 can be formed by a process that includes electroplating. - Moreover, in some embodiments, the polymer layers 282A and 282B can comprise a relatively rigid transparent polymer, such as PET or paralyene. And in at least one such embodiment, the polymer layers 282A and 282B can have a thickness between 10 and 50 micrometers, such as 15 micrometers. Other thicknesses of the polymer layers 282A and 282B are possible as well. In an example, the polymer layers 282A and 282B can be formed by a process that includes chemical vapor deposition.
- In an example, the plurality of
conductive loops 272 can be formed by a process that includes etching a portion of a metal layer disposed between polymer layers with an inductively coupled plasma, such as an oxygen plasma. -
FIG. 3 a is a top view of an eye-mountableelectronic device 310.FIG. 3 b is a side view of the eye-mountableelectronic device 310 shown inFIG. 3 a. It is noted that relative dimensions inFIGS. 3 a and 3 b are not necessarily to scale, but have been rendered for purposes of explanation only in describing the arrangement of the eye-mountableelectronic device 310. The eye-mountable device 310 is formed of atransparent polymer 320 shaped as a curved disk. Thetransparent polymer 320 can be a substantially transparent material to allow incident light to be transmitted to the eye while the eye-mountable device 310 is mounted to the eye. Thetransparent polymer 320 can be a bio-compatible material similar to those employed to form vision correction and/or cosmetic contact lenses in optometry, such as PET, polymethyl methacrylate (“PMMA”), silicone hydrogels, combinations of these, etc. Thetransparent polymer 320 could take the form of or be similar in form to thepolymeric material 120. - The
transparent polymer 320 can be formed with one side having a posterior side 326 (i.e., concave surface) suitable to fit over a corneal surface of an eye. The opposing side of the disk can have anterior side 324 (i.e., convex surface) that does not interfere with eyelid motion while the eye-mountable device 310 is mounted to the eye. A circularouter side edge 328 connects theposterior side 326 andanterior side 324. - The eye-
mountable device 310 can have dimensions similar to a vision correction and/or cosmetic contact lenses, such as a diameter of approximately 1 centimeter, and a thickness of about 0.1 to about 0.5 millimeters. However, the diameter and thickness values are provided for explanatory purposes only. In some embodiments, the dimensions of the eye-mountable device 310 can be selected according to the size and/or shape of the corneal surface and/or the scleral surface of the wearer's eye. - While the eye-
mountable device 310 is mounted in an eye, theanterior side 324 faces outward to the ambient environment while theposterior side 326 faces inward, toward the corneal surface. Theanterior side 324 can therefore be considered an outer, top surface of the eye-mountable device 310 whereas theposterior side 326 can be considered an inner, bottom surface. The “top” view shown inFIG. 3 a is facing theanterior side 324. - The
structure 330 is embedded in thetransparent polymer 320. Thesubstrate 330 can be embedded to be situated along anouter periphery 322 of thetransparent polymer 320, away from acenter region 321. Thestructure 330 does not interfere with vision because it is too close to the eye to be in focus and is positioned away from thecenter region 321 where incident light is transmitted to the light-sensing portions of the eye. Thestructure 330 can take the form or be similar in form to thesubstrate 130 and/or thestructure 230. - The
structure 330 has anouter diameter 332 and aninner diameter 334 and includeselectronics 340,electronics 350, asensor 360, and anantenna 370 disposed thereon. Theouter diameter 332 may take the form of or be similar in form to theouter diameter 232, theinner diameter 334 may take the form of or be similar in form to theinner diameter 234, theelectronics 340 may take the form of or be similar in form to thecontroller 150 and/or theelectronics 240, theelectronics 350 may take the form or be similar in form to thecontroller 150 and/or theelectronics 250, and thesensor 360 may take the form or be similar in form to thebio-analyte sensor 162 and/or thesensor 260. - The
antenna 370 is configured for communications and/or harvesting energy, like theantenna 270 is configured for communications and/or harvesting energy. Theantenna 370 includes a plurality ofconductive loops 372 spaced apart from each other between theouter diameter 332 and theinner diameter 334. In the illustrated example, the plurality ofconductive loops 372 includes threeconductive loops 372A, 372B, and 372C. However, in other examples, a plurality of conductive loops may include more than three conductive loops, such as five conductive loops, nine conductive loops, etc. When thestructure 330 is embedded in thetransparent polymer 320, theconductive loops 372A, 372B, and 372C may move relative to each other. - The
conductive loops 372A, 372B, and 372C can have an arrangement similar to an arrangement of theconductive loops FIGS. 3 a and 3 b, theconductive loops 372A, 372B, and 272C are connected in parallel. With this arrangement, each of the conductive loops in the plurality ofconductive loops 372 is electrically connected to theelectronics 340, theelectronics 350, and thesensor 360 via afirst connection 374 and asecond connection 376. And theelectronics 340, theelectronics 350, and thesensor 360 are electrically connected via thefirst connection 374 and thesecond connection 376. Thefirst connection 374 and thesecond connection 376 may take the form of or be similar in form to thefirst connection 274 and thesecond connection 276 and/or theinterconnects FIGS. 3 a and 3 b, theconductive loops 372A, 372B, and 372C are substantially concentric. And as shown inFIGS. 3 a and 3 b, theconductive loops 372A, 372B, and 372C are spaced apart from each other between theouter diameter 332 and theinner diameter 334. - The
conductive loops 372A, 372B, and 372C may have a width that is the same or similar to a width of theconductive loops conductive loops 372 can comprise a respective metal layer disposed between respective polymer layers, like the conductive loops in the plurality ofconductive loops 272 comprise a respective metal layer disposed between respective polymer layers. And the plurality ofconductive loops 372 can be formed like the plurality ofconductive loops 272 is formed. - In the illustrated example, the metal and polymer layers in each conductive loop in the plurality of
conductive loops 372 are spaced apart from the metal and polymer layers in each adjacent conductive loop in the in the plurality ofconductive loops 372. In some embodiments, thetransparent polymer 320 can extend between adjacent conductive loops (e.g., theconductive loop 372A and the conductive loop 372B and/or the conductive loop 372B and the conductive loop 372C) in the plurality ofconductive loops 372. - Moreover, in the illustrated example, the metal and polymer layers of conductive loop 372B are spaced apart from the metal and polymer layers of adjacent
conductive loop 372A by afirst distance 394, and the metal and polymer layers of conductive loop 372B are spaced apart from the metal and polymer layers of adjacent conductive loop 372C by asecond distance 396. In an example, thefirst distance 394 and thesecond distance 396 can be between 100 to 200 micrometers. Other distances are possible as well. - The
first distance 394 could be a different value than thesecond distance 396. In some embodiments, thefirst distance 394 can be greater (or less) than thesecond distance 396. And thefirst distance 394 and/or thesecond distance 396 could vary. In some embodiments, thefirst distance 394 can vary based on a rotational orientation of the conductive loop 372B relative to theconductive loop 372A and/or the conductive loop 372C. Moreover, in some embodiments, thesecond distance 396 can vary based on a rotational orientation of the conductive loop 372B relative to the conductive loop 372C and/or theconductive loop 372A. -
FIG. 3 c is a side cross-section view of the eye-mountable 310 while mounted to acorneal surface 384 of aneye 380, according to an example embodiment.FIG. 3 d is a close-in side cross-section view enhanced to show tear film layers 390, 392 surrounding exposedsurfaces mountable device 310, according to an example embodiment. It is noted that relative dimensions inFIGS. 3 c and 3 d are not necessarily to scale, but have been rendered for purposes of explanation only in describing the arrangement of the eye-mountableelectronic device 310. For example, the total thickness of the eye-mountable device 310 can be about 200 micrometers, while the thickness of the tear film layers 390, 392 can each be about 10 micrometers, although this ratio may not be reflected in the drawings. Some aspects are exaggerated to allow for illustration and facilitate explanation. - The
eye 380 includes acornea 382 that is covered by bringing theupper eyelid 386 andlower eyelid 388 together over the top of theeye 380. Incident light is received by theeye 380 through thecornea 382, where light is optically directed to light-sensing elements of the eye 380 (e.g., rods and cones, etc.) to stimulate visual perception. The motion of theeyelids corneal surface 384 of theeye 380. The tear film is an aqueous solution secreted by the lacrimal gland to protect and lubricate theeye 380. When the eye-mountable device 310 is mounted in theeye 380, the tear film coats both the anterior andposterior sides - The tear film layers 390, 392 are distributed across the
corneal surface 384 and/or theposterior side 324 by motion of theeyelids eyelids corneal surface 384 and/or theanterior side 324 of the eye-mountable device 310. Thetear film layer 390 on thecorneal surface 384 also facilitates mounting the eye-mountable device 310 by capillary forces between theanterior side 326 and thecorneal surface 384. In some embodiments, the eye-mountable device 310 can also be held over the eye in part by vacuum forces against thecorneal surface 384 due to the concave curvature of the eye-facinganterior side 326. - In some embodiments, a polymer layer defining the
anterior side 326 may be greater than 50 micrometers thick, whereas a polymer layer defining theposterior side 324 may be less than 150 micrometers. Thus, when thesensor 360 is mounted on an outward-facing surface 335 (as shown inFIG. 3 d) thesensor 360 may be at least 50 micrometers away from theanterior side 324 and may be a greater distance away from theposterior side 326. However, in other examples, thesensor 360 may be mounted on an inward-facingsurface 333 of thestructure 330 such that thesensor 360 is facing theposterior side 326. Thesensor 360 could also be positioned closer to theanterior side 324 than theposterior side 326. With this arrangement, thesensor 360 can receive analyte concentrations in thetear film 392 via achannel 373. In some examples, analyte concentrations in thetear film 390 and/or 392 may diffuse through thetransparent polymer 320 to thesensor 360. As a result, the eye-mountable device 310 might not include thechannel 373. - While the body-mountable device has been described as comprising the eye-
mountable device 110 and/or the eye-mountable device 310, the body-mountable device could comprise other mountable devices that are mounted on or in other portions of the human body. - For example, in some embodiments, the body-mountable device may comprise a tooth-mountable device. In some embodiments, the tooth-mountable device may take the form of or be similar in form to the eye-
mountable device 110 and/or the eye-mountable device 310. For instance, the tooth-mountable device could include a polymeric material or a transparent polymer that is the same or similar to any of the polymeric materials or transparent polymers described herein and a substrate or a structure that is the same or similar to any of the substrates or structures described herein. With such an arrangement, the tooth-mountable device may be configured to detect at least one analyte in a fluid (e.g., saliva) of a user wearing the tooth-mountable device. - Moreover, in some embodiments, the body-mountable device may comprise a skin-mountable device. In some embodiments, the skin-mountable device may take the form of or be similar in form to the eye-
mountable device 110 and/or the eye-mountable device 310. For instance, the skin-mountable device could include a polymeric material or a transparent polymer that is the same or similar to any of the polymeric materials or transparent polymers described herein and a substrate or a structure that is the same or similar to any of the substrates or structures described herein. With such an arrangement, the skin-mountable device may be configured to detect at least one analyte in a fluid (e.g., perspiration, blood, etc.) of a user wearing the skin-mountable device. - Further, some embodiments may include privacy controls which may be automatically implemented or controlled by the wearer of a body-mountable device. For example, where a wearer's collected physiological parameter data and health state data are uploaded to a cloud computing network for trend analysis by a clinician, the data may be treated in one or more ways before it is stored or used, so that personally identifiable information is removed. For example, a user's identity may be treated so that no personally identifiable information can be determined for the user, or a user's geographic location may be generalized where location information is obtained (such as to a city, ZIP code, or state level), so that a particular location of a user cannot be determined.
- Additionally or alternatively, wearers of a body-mountable device may be provided with an opportunity to control whether or how the device collects information about the wearer (e.g., information about a user's medical history, social actions or activities, profession, a user's preferences, or a user's current location), or to control how such information may be used. Thus, the wearer may have control over how information is collected about him or her and used by a clinician or physician or other user of the data. For example, a wearer may elect that data, such as health state and physiological parameters, collected from his or her device may only be used for generating an individual baseline and recommendations in response to collection and comparison of his or her own data and may not be used in generating a population baseline or for use in population correlation studies.
-
FIG. 4 is a top view of astructure 430, according to an example embodiment. In particular, thestructure 430 includes aspacer 478 configured to maintain substantially uniform spacings between adjacent conductive loops in a plurality ofconductive loops 472. The term “substantially uniform,” as used in this disclosure, refers to exactly uniform and/or one or more deviations from exactly uniform that do not significantly impact embedding an structure in a body-mountable device as described herein. - More specifically, the
structure 430 has anouter diameter 432 and aninner diameter 434 and includeselectronics 440,electronics 450, a sensor 460, and anantenna 470 disposed thereon. Theouter diameter 432 may take the form of or be similar in form to theouter diameter 232 and/or theouter diameter 332; theinner diameter 434 may take the form of or be similar in form to theinner diameter 234 and/or theinner diameter 334; theelectronics 440 may take the form of or be similar in form to thecontroller 150, theelectronics 240, and/or theelectronics 340, theelectronics 450 may take the form or be similar in form to thecontroller 150, theelectronics 250, and/or theelectronics 350; and the sensor 460 may take the form or be similar in form to thebio-analyte sensor 162, thesensor 260, and/or thesensor 360. - The
antenna 470 is configured for communications and/or harvesting energy, like theantenna 270 and theantenna 370 are configured for communications and/or harvesting energy. As noted, theantenna 470 includes the plurality ofconductive loops 472. The plurality ofconductive loops 472 is spaced apart from each other between theouter diameter 432 and theinner diameter 434. In the illustrated example, the plurality ofconductive loops 472 includes threeconductive loops 472A, 472B, and 472C. However, in other examples, a plurality of conductive loops may include more than three conductive loops, such as five conductive loops, nine conductive loops, etc. - The
conductive loops 472A, 472B, and 472C can have an arrangement similar to an arrangement of theconductive loops conductive loops 372A, 372B, and 372C. As shown inFIG. 4 , theconductive loops 472A, 472B, and 472C are connected in parallel. With this arrangement, each of the conductive loops in the plurality ofconductive loops 472 is electrically connected to theelectronics 440, theelectronics 450, and the sensor 460 via afirst connection 474 and asecond connection 476. And theelectronics 440, theelectronics 450, and the sensor 460 are electrically connected via thefirst connection 474 and thesecond connection 476. Thefirst connection 474 and thesecond connection 476 may take the form of or be similar in form to theinterconnects first connection 274 and thesecond connection 276, and/or thefirst connection 374 and thesecond connection 376. - Moreover, as shown in
FIG. 4 , theconductive loops 472A, 472B, and 472C are substantially concentric. And as shown inFIG. 4 , theconductive loops 472A, 472B, and 472C are spaced apart from each other between theouter diameter 432 and theinner diameter 434. In an example, theconductive loops 472A, 472B, and 472C can be spaced apart from adjacent conductive loops by a distance between 100 to 200 micrometers. Other distances are possible as well. - The
conductive loops 472A, 472B, and 472C may have a width that is the same or similar to a width of theconductive loops conductive loops 372A, 372B, and 372C. Moreover, each of the conductive loops in the plurality ofconductive loops 472 can comprise a respective metal layer disposed between respective polymer layers, like the conductive loops in the plurality ofconductive loops 272 comprise a respective metal layer disposed between respective polymer layers. And the plurality ofconductive loops 472 can be formed like the plurality ofconductive loops 272 and/or the plurality ofconductive loops 372 is formed. - The
structure 430 may be embedded in a transparent polymer, such as thetransparent polymer 320. For instance, when thestructure 430 is embedded in the transparent polymer, when each of the conductive loops in the plurality ofconductive loops 472 comprise a respective metal layer disposed between respective polymer layers, the metal and polymer layers in each conductive loop in the plurality ofconductive loops 472 can be spaced apart from the metal and polymer layers in each adjacent conductive loop in the plurality ofconductive loops 472. And the transparent polymer can extend between adjacent conductive loops in the plurality ofconductive loops 472. - As noted, the
structure 430 includes thespacer 478. When thestructure 430 is embedded in the transparent polymer theconductive loops 472A, 472B, and 472C may not move relative to each other based on thespacer 478. - As shown in
FIG. 4 , thespacer 478 is connected to theconductive loops 472A, 472B, and 472C and is located on thestructure 430 substantially opposite of thesensor 260. Other locations of thespacer 478 on thestructure 430 are possible as well. For instance, thespacer 478 could be located on thestructure 430 at a predetermined rotational orientation, such as 30 degrees, 45 degrees, 60 degrees, 90 degrees, etc. The term “substantially opposite,” as used in this disclosure, refers to exactly opposite (e.g., a rotational orientation of 180 degrees) or one or more deviations from exactly opposite that do not significantly impact embedding a structure in a body-mountable device as described herein. - The
spacer 478 could take various different forms in various different embodiments. For example, in some embodiments, thespacer 478 can have a width between 50 and 300 micrometers. Other widths of thespacer 478 are possible as well. Moreover, in some embodiments, thespacer 478 can comprise a metal, such as gold, platinum, palladium, titanium, aluminum, copper, and/or silver. In some examples, thespacer 478 can comprise the same metal as the respective metal layers of theconductive loops 472A, 472B, and 472C. However, in other examples, thespacer 478 can comprise a different metal than the respective metal layers of theconductive loops 472A, 472B, and 472C. In an example, thespacer 478 can be formed by a process that includes electroplating. - Furthermore, in some embodiments, the
spacer 478 can comprise a polymeric material, such as PET or paralyene. In some examples, thespacer 478 can comprise the same polymeric material as the respective polymer layers of theconductive loops 472A, 472B, and 472C. However, in other examples, thespacer 478 can comprise a different polymeric material than the respective polymer layers of theconductive loops 472A, 472B, and 472C. In an example, thespacer 478 can be formed by a process that includes chemical vapor deposition. - And in some embodiments, the
spacer 478 can comprise a metal layer disposed between polymer layers, like the respective metal layers disposed between the respective polymer layers of theconductive loops 472A, 472B, and 472C. - In an example, the
spacer 478 is formed by a process that includes etching a portion of a metal and/or a polymeric material with an inductively coupled plasma, such as an oxygen plasma. - In the illustrated example, the
structure 430 includes one spacer, thespacer 478. However, in other examples, a structure may include more than one spacer, such as two spacers, three spacers, four spacers, etc. For instance, a structure could include one or more spacers configured to maintain substantially uniform spacings between adjacent conductive loops in a plurality of conductive loops. And each spacer in the one or more spacers could be located on the structure in a predetermined rotational orientation, such as 30 degrees, 45 degrees, 60 degrees, 90 degrees, etc. Each of the spacers in the one or more spacers could take the form or be similar in form to thespacer 478. -
FIG. 5 is a top view of astructure 530, according to an example embodiment. In particular, thestructure 530 includes anantenna 570 that includes a plurality ofconductive loops 572 that includes threeconductive loops 572A, 572B, and 572C. As shown inFIG. 5 , theconductive loops 572A, 572B, and 572C are connected in series. - More specifically, the
structure 530 has anouter diameter 532, and aninner diameter 534. Theouter diameter 532 may take the form of or be similar in form to theouter diameter 232, theouter diameter 332, and/or theouter diameter 432; and theinner diameter 434 may take the form of or be similar in form to theinner diameter 234, theinner diameter 334, and or theinner diameter 434. - As noted, the
structure 530 includes theantenna 570. Theantenna 570 is configured for communications and/or harvesting energy, like theantenna 270, theantenna 370, and theantenna 470 are configured for communications and/or harvesting energy. Theantenna 570 includes the plurality ofconductive loops 572 spaced apart from each other between theouter diameter 532 and theinner diameter 534. In the illustrated example, the plurality ofconductive loops 572 includes theconductive loops 572A, 572B, and 572C. However, in other examples, a plurality of conductive loops may include more than three conductive loops, such as five conductive loops, nine conductive loops, etc. - As noted, the
conductive loops 572A, 572B, and 572C are connected in series. With this arrangement, theconductive loop 572A is electrically connected to anelectrical component 555 via afirst connection 574 and the conductive loop 572C is electrically connected to theelectrical component 555 via asecond connection 576. Theelectrical component 555 could include electronics (e.g., thecontroller 150, theelectronics 240, theelectronics 250, theelectronics 340, theelectronics 350, theelectronics 440, and/or the electronics 450) and/or a sensor (e.g., theanalyte bio-sensor 162, thesensor 260, thesensor 360, and/or the sensor 460). When theelectrical component 555 includes more than one component, the more than one component could be arranged in series. - As shown in
FIG. 5 , the conductive loop 572C is connected to the second connection via abridge 573. Thebridge 573 may insulate the conductive loop 572C from the conductive loop 572B and/or theconductive loop 572A. In some embodiments, thebridge 573 can comprise a polymeric material, such as PET or paralyene. And in some examples, thebridge 573 can comprise the same polymeric material as thespacer 478 and/or the respective polymer layers of theconductive loops conductive loops 372A, 372B, and 372C, and/or theconductive loops 472A, 472B, and 472C. However, in other examples, thebridge 573 can comprise a different polymeric material than thespacer 478 and/or the respective polymer layers. Thebridge 573 may be other materials as well, such as silicon. Moreover, in some embodiments, thebridge 573 may include an integrated circuit. And in at least one such embodiment, theconductive loop 572A, the conductive loop 572B, and the conductive loop 572C may cross at thebridge 573. - In the illustrated example, the plurality of
conductive loops 572 is a continuous material arranged in multiple windings, shown as theconductive loops 572A, 572B, and 572C. However, in other examples, a plurality of conductive loops may not be a continuous material. - As shown in
FIG. 5 , theconductive loops 572A, 572B, and 572C are substantially concentric. And as shown inFIG. 5 , theconductive loops 572A, 572B, and 572C are spaced apart from each other between theouter diameter 532 and theinner diameter 534. In an example, theconductive loops 572A, 572B, and 572C are spaced apart from adjacent conductive loops by a distance between 100 to 200 micrometers. Other distances are possible as well. - The
conductive loops 572A, 572B, and 572C may have a width that is the same or similar to a width of theconductive loops conductive loops 372A, 372B, and 372C; and/or theconductive loops 472A, 472B, and 472C. Moreover, each of the conductive loops in the plurality ofconductive loops 572 can comprise a respective metal layer disposed between respective polymer layers, like the conductive loops in the plurality ofconductive loops 272 comprise a respective metal layer disposed between respective polymer layers. In an example, theconductive loops 572A, 572B, and 572C can be formed by a process that includes electroplating, chemical vapor deposition, and etching, using an inductively coupled plasma, such as oxygen plasma. - The
structure 530 may be embedded in a transparent polymer, like thestructure 330 is embedded in thetransparent polymer 320. When thestructure 530 is embedded in the transparent polymer, theconductive loops 572A, 572B, and 572C may move relative to each other. In an example, movement of theconductive loops 572A, 572B, and 572C may be the same as movement of theconductive loops 372A, 372B, and 372C. However, in other examples, movement of theconductive loops 572A, 572B, and 572C may be greater (or less) than movement of theconductive loops 372A, 372B, and 372C. - For instance, when the
structure 530 is embedded in the transparent polymer and each of the conductive loops in the plurality ofconductive loops 572 comprise a respective metal layer disposed between respective polymer layers, the metal and polymer layers in each conductive loop in the plurality ofconductive loops 572 can be spaced apart from the metal and polymer layers in each adjacent conductive loop in the plurality ofconductive loops 572. And the transparent polymer can extend between adjacent conductive loops in the plurality ofconductive loops 572. - Moreover, the metal and polymer layers of conductive loop 572B can be spaced apart from the metal and polymer layers of adjacent
conductive loop 572A by a first distance, and the conductive loop 572B may be spaced apart from the adjacent conductive loop 572C by a second distance. The first and second distances can be between 100 to 200 micrometers. Other distances are possible as well. - The first distance could be a different value than the second distance. For instance, the first distance can be greater (or less) than the second distance. And the first distance and/or the second distance could vary. As one example, the first distance can vary based on a rotational orientation of the conductive loop 572B and/or the conductive loop 572C relative to the
conductive loop 572A. Moreover, in some embodiments, the second distance can vary based on a rotational orientation of the conductive loop 572C and/or theconductive loop 572A relative to the conductive loop 572B. -
FIG. 6 is a flow chart illustrating a method, according to an example embodiment. More specifically, themethod 600 involves forming a first polymer layer, as shown byblock 602. Themethod 600 may then involve positioning a structure on the first polymer layer, as shown byblock 604. Further, themethod 600 may then involve conforming the structure positioned on the first polymer layer to a curvature of the first polymer layer, as shown byblock 606. Themethod 600 may then involve forming a second polymer layer over the first polymer layer and the structure, as shown byblock 608. - For purposes of illustration, the
method 600 is described below as being carried out by a fabrication device that utilizes cast or compression molding. It should be understood, however, thatmethod 600 may be carried out by a fabrication device that utilizes other methods for forming the polymer layers. - Moreover, for purposes of illustration, the
method 600 is described below in a scenario where a body-mountable device comprises an eye-mountable device. It should be understood, however, that themethod 600 may involve scenarios where the body-mountable device comprises other mountable devices that are mounted on or in other portions of the human body. For example, themethod 600 may involve scenarios where the body-mountable device comprises a tooth-mountable device and/or a skin-mountable device as described herein. - A. Forming a First Polymer Layer
- As mentioned above, at
block 602, the fabrication device may be used to form a first polymer layer. The fabrication device may include molding pieces, such as molding pieces that are suitable for cast molding.FIG. 7 a illustrates afabrication device 700 that includes example molding pieces that may be used to form the first polymer layer. In particular,FIG. 7 a illustrates afabrication device 700 including afirst molding piece 702 and asecond molding piece 704. Thefirst molding piece 702 and thesecond molding piece 704 may define a first cavity. Thesecond molding piece 704 may be filled with a polymer material 706, and the polymer material 706 may be compressed into afirst polymer layer 708 by thefirst molding piece 702. - After the polymer material 706 is compressed into the
first polymer layer 708, thefabrication device 700 may cure thefirst polymer layer 708. Curing involves the hardening of a polymer material by cross-linking of polymer chains, and curing may be, for example, brought about by chemical additives, ultraviolet radiation, electron beam, and/or heat. In an example, the polymer material 706 can be a light-curable polymer material, and thefabrication device 700 may be configured to cure the light-curable polymer material using light, such as ultraviolet light or visible light. - In an example, the
first polymer layer 708 may be cured to a partially-cured state. In an example, this may involve curing the material to a partially-cured state that is approximately 50-75% of a fully cured state. Other partially-cured states are possible as well. Beneficially, by partially curing the first polymer layer to a partially-cured state, thefirst polymer layer 708 may have a tackiness that facilitates adhesion thereto. With this arrangement, the tackiness may ensure that a structure conformed to a curvature of thefirst polymer layer 708 remains securely fixed in a given location during subsequent formation steps. - The tackiness exhibited by the partially-cured
first polymer layer 708 may be different for different polymers. Accordingly, thefabrication device 700 may be configured to cure different polymer materials differently than other polymer materials (e.g., a first polymer material may be cured more than a second polymer material). Further, in addition to light curing, other methods of curing are possible as well, such as chemical additives and/or heat. Yet still further, in other example embodiments, the first polymer layer may be completely cured. Alternatively, thefabrication device 700 may bypass the curing process at this stage. - The
first molding piece 702 and thesecond molding piece 704 may be configured to achieve a given desired thickness of thefirst polymer layer 708. For instance, in an example, thefirst polymer layer 708 can have a thickness of less than 150 micrometers. In an example embodiment, thefirst molding piece 702 and thesecond molding piece 704 can be designed so as to allow for a layer having less than a 150 micrometer thickness between the two cavities. As such, when thefirst molding piece 702 and thesecond molding piece 704 are pressed together during the formation of thefirst polymer layer 708, the resultingpolymer layer 708 will have a thickness of less than 150 micrometers. - In an example, the thickness of the
first polymer layer 708 can be selected based on a particular analyte or analytes an eye-mountable device is configured to detect. For example, an optimal thickness for a first analyte may be 10 micrometers, while an optimal thickness for a second analyte may be 25 micrometers. Other examples are possible as well. - In an example, the polymer material 706 can be any material that can form an eye-compatible polymer layer. For example, the polymer material 706 may be a formulation containing polymerizable monomers, such as hydrogels, silicone hydrogels, silicone elastomers, and rigid gas permeable materials. Further, the polymer material 706 may form a transparent or substantially transparent polymer layer. As such, the use of the polymer material 706 may result in an eye-mountable device through which the wearer can see when mounted on the wearer's eye. In an example, the polymer material 706 can be a hydrogel material, such as silicone hydrogel. As known in the art, hydrogel materials are commonly used in contact-lens technology and are well-suited for eye-mountable devices. Other materials are possible as well.
- In an example, the
first molding piece 702 and/or thesecond molding piece 704 can be configured so as to allow sufficient pinch off to provide for suitable edges for an eye-mountable device. - The
first polymer layer 708 defines aposterior side 710 of an eye-mountable device. That is, thefirst polymer layer 708 defines an outer edge of the eye-mountable device. When mounted on an eye of a user, theposterior side 710 of the eye-mountable device defined by thefirst polymer layer 708 corresponds to a side of the device touching the eye of the user. Thefirst molding piece 702 may be shaped so as to define a shape of theposterior side 710. For example, a curvature of theposterior side 710 may be defined by thefirst molding piece 702. Thesecond molding piece 704 may be shaped so as to define a shape of apositioning surface 711 of the first polymer layer. For example, thesecond molding piece 704 may define a curvature of apositioning surface 711 of thefirst polymer layer 708. In an example, a structure can be conformed to the curvature of thepositioning surface 711 of thefirst polymer layer 708. - The
first polymer layer 708 can further comprise analignment feature 712. In an example, thealignment feature 712 can comprise an asymmetric peg. The asymmetric peg can be a variety of shapes. For instance, the asymmetric peg can have a star-shaped or cross-shaped cross section. Other shapes of the asymmetric peg are possible as well. - As mentioned above, although
FIG. 7 a illustrates forming thefirst polymer layer 708 through cast molding, other methods for formingfirst polymer layer 708 are possible as well. For example, thefirst polymer layer 708 may be formed via injection molding. In injection molding, rather than polymer material being compressed between molding pieces, molding material may be heated and injected or otherwise forced into a molding piece or pieces. The injected molding material may then cool and harden to the configuration of the molding piece or pieces. - As another example, the
first polymer layer 708 may be formed via spin casting. Through spin-casting techniques, the fabrication device may form a first polymer layer of a precise thickness. In an example, a spin-casting mold may be spun along its central access at a set speed, and the polymer may be introduced to the mold as the mold is spinning in order to form a first polymer layer. The final thickness of the first polymer layer may be influenced by various factors, including but not limited to the spin-casting mold, the amount of polymer introduced to the spin-casting mold, properties of the polymer such as viscosity, and/or the speed at which the spin-casting mold is rotated. These factors may be varied in order to result in a first polymer layer of a well-defined thickness. - B. Positioning a Structure on the First Polymer Layer
- As mentioned above, at
block 604, a structure may be positioned on the first polymer layer.FIGS. 7 b and 7 c illustrate an example in which astructure 730 is positioned on thefirst polymer layer 708. - The
structure 730 has anouter diameter 732 and aninner diameter 734 and includeselectronics 740,electronics 750, asensor 760, and anantenna 770 disposed thereon. Thestructure 730 may take the form of or be similar in form to thesubstrate 130, thestructure 230, thestructure 330, thestructure 430 and/or thestructure 530. In some embodiments, thestructure 730 can further include one or more spacers, such as thespacer 478. - The
outer diameter 732 may take the form of or be similar in form to theouter diameter 232, theouter diameter 332, theouter diameter 432, and/or theouter diameter 532; theinner diameter 734 may take the form of or be similar in form to theinner diameter 234, theinner diameter 334, and or theinner diameter 434 and/or theouter diameter 534; theelectronics 740 may take the form or be similar in form to thecontroller 150, theelectronics 240, theelectronics 340, theelectronics 440 and/or theelectronics 555; theelectronics 750 may take the form of or be similar in form to thecontroller 150, theelectronics 250, theelectronics 350, theelectronics 450, and/or theelectronics 555; and thesensor 760 may take the form of or be similar in form to thebio-analyte sensor 162, thesensor 260, thesensor 360, the sensor 460. - As noted, the
structure 730 includes theantenna 770. Theantenna 770 is configured for communications and/or harvesting energy, like theantenna 270, theantenna 370, theantenna 470, and theantenna 570 are configured for communications and/or harvesting energy. Theantenna 770 includes a plurality of conductive loops spaced 772 apart from each other between theouter diameter 732 and theinner diameter 734. In the illustrated example, the plurality ofconductive loops 772 includes threeconductive loops - As shown in
FIG. 7 b, theconductive loops FIG. 7 b, theconductive loops outer diameter 732 and theinner diameter 734. In an example, theconductive loops conductive loops conductive loops 572A, 572B, and 572C are connected in series. - In order to position the
structure 730, thefabrication device 700 may separate thefirst molding piece 702 from thesecond molding piece 704. When thefabrication device 700 separates thefirst molding piece 702 from thesecond molding piece 704, thefirst polymer layer 708 may stick to a side of thefirst molding piece 702. In an example, thefirst polymer layer 708 and/or thefirst molding piece 702 can be surface treated, such that thefirst polymer layer 708 sticks to the side of thefirst molding piece 702. Additionally or alternatively, thesecond molding piece 704 can be surface treated, such that thefirst polymer layer 708 sticks to the side of thefirst molding piece 702. - In an example, positioning the
structure 730 on thefirst polymer layer 708 can include aligning thestructure 730 with thealignment feature 712. In one example, theinner diameter 734 can be asymmetric and thealignment feature 712 includes an asymmetric peg such that theinner diameter 734 receives thealignment feature 712 in only a predetermined rotational orientation (relative alignment between thealignment feature 712 and theinner diameter 734 inFIG. 7 c is not necessarily to scale). However, other ways of providing a predetermined rotational orientation of thestructure 730 by alignment with thealignment feature 712 are also possible. - Alternatively, the
fabrication device 700 can include a positioning apparatus (not shown), such as a robotic system, configured to position thestructure 730 on thefirst polymer layer 708. For instance, the positioning apparatus may (i) pick up the structure 730 (e.g., via suction), (ii) position thestructure 730 above thefirst polymer layer 708, and then (iii) lower thestructure 730 toward thefirst polymer layer 708. With this arrangement, the positioning apparatus may position thestructure 730 in a predetermined rotational orientation. When thestructure 730 is positioned in a predetermined orientation, the positioning apparatus may then release the structure 730 (e.g., by releasing the suction). With this approach, thefirst polymer layer 708 might not include thealignment feature 712. - The positioning apparatus may further include a vision system configured to assist with positioning the
structure 730 on thefirst polymer layer 708. Such a vision system may facilitate guiding thestructure 730 to a precise location on thefirst polymer layer 708. In an example, the vision system can be appropriate for situations in which one or more production specifications for an eye-mountable device, such as the eye-mountable device 310, have requirements with very low tolerances related to the positioning of a sensor, such as thesensor 360, within the eye-mountable device 310. - In some situations, such as for large-scale production purposes, it may be desirable to not only place the
structure 730 in a predetermined orientation, but it may also be desirable to repeatedly place and maintain thestructure 730 at this precise location for a plurality of eye-mountable devices. Beneficially, fabrication of an eye-mountable device in accordance with an example embodiment allows for such repeatable and precise positioning. -
FIG. 7 c illustrates thestructure 730 positioned on thefirst polymer layer 708. With this arrangement, thesensor 760 may be mounted at a particular angle along a circumference of thefirst polymer layer 708. As a result, thesensor 760 may be placed at a precise location in an XYZ plane on thefirst polymer layer 708. As one example, thesensor 760 may rest at a 6 o'clock position of thefirst polymer layer 708. As another example, thesensor 760 may rest at a 12 o'clock position of thefirst polymer layer 708. - C. Conforming the Structure Positioned on the First Polymer Layer to a Curvature of the First Polymer Layer
- As mentioned above, at
block 606, the structure positioned on the first polymer layer may be conformed to a curvature of the first polymer layer.FIG. 7 d illustrates an example in which thestructure 730 is conformed to the curvature of thepositioning surface 711 of thefirst polymer layer 708. - In an example, conforming the
structure 730 to the curvature of thepositioning surface 711 of the first polymer layer can include bending thestructure 730. In one example, the positioning apparatus may bend thestructure 730, such that thestructure 730 conforms to the curvature of thepositioning surface 711 of thefirst polymer layer 708. The positioning apparatus may bend thestructure 730 by applying a force and/or a torque to one or more portions of thestructure 730. However, other ways of conforming thestructure 730 to the curvature of thepositioning surface 711 are possible as well. - Moreover, in an example, during conforming the
conductive loops structure 730 when it is conformed to a curvature of the first polymer layer, such as the curvature of thepositioning surface 711 of thefirst polymer layer 708. An amount and/or type of movement of theconductive loops conductive loops first polymer layer 708. Other parameters are possible as well. And in embodiments where thestructure 730 further includes one or more spacers, such as thespacer 478, theconductive loops - During fabrication of an eye-mountable device, such as the eye-
mountable device 310, it may be desirable for thestructure 730 to remain in a fixed position during fabrication of the eye-mountable device. For instance, movement of thestructure 730 during subsequent formation steps, such as formation of a second polymer layer, may result in improper placement of thestructure 730 relative to the surrounding polymer layers. As one example, movement of thestructure 730 during filling a mold piece with a polymeric material to form the second polymer layer and/or curing the second polymer layer can result in improper placement of thestructure 730 relative to the surrounding polymer layers. - Therefore, in an example, an adhesive is applied to the
structure 730 and/or thefirst polymer layer 708 before thestructure 730 is positioned on thefirst polymer layer 708. The applied adhesive may facilitate adhesion of thestructure 730 to thefirst polymer layer 708. For instance, a small amount of adhesive may be applied to a curedfirst polymer layer 708, and thestructure 730 may be conformed to a curvature of thefirst polymer layer 708 and then the adhesive may be cured such that thestructure 730 adheres to thefirst polymer layer 708. Additionally or alternatively, a small amount of adhesive may be applied to thestructure 730, and thestructure 730 may then be conformed to a curvature of the first polymer layer 708 (e.g., a cured first polymer layer) and then the adhesive may be cured such that thestructure 730 adheres to thefirst polymer layer 708. With this arrangement, thestructure 730 may remain adhered to thefirst polymer layer 708 in a secure location during subsequent formation steps. In some embodiments, a force and/or a torque can be applied to thestructure 730 during curing of the adhesive. - As noted above, in an example, the
first polymer layer 708 in a partially-cured state may have a tackiness that facilitates adhesion thereto. With this arrangement, thestructure 730 may remain adhered to thefirst polymer layer 708 in a secure location during subsequent formation steps. - D. Forming a Second Polymer Layer Over the First Polymer Layer and the Structure
- As mentioned above, at
block 608, the fabrication device may form a second polymer layer over the first polymer layer and the structure, such that the structure is fully enclosed by the first polymer layer and the second polymer layer.FIG. 7 e illustrates thefabrication device 700 including example molding pieces that may be used to form the second polymer layer. In particular,FIG. 7 e illustrates athird molding piece 722. Thefirst molding piece 702 and thethird molding piece 722 may define a second cavity. - The
first molding piece 702, which already holds thefirst polymer layer 708 to which thestructure 730 is mounted (as illustrated inFIG. 7 d), may be filled with a polymer material 724. The polymer material 724 may be formed into a second polymer layer 726 by compression between thefirst molding piece 702 and thethird molding piece 722. As a result, the second polymer layer 726 may mold over thestructure 730, such that thestructure 730 is fully enclosed by thefirst polymer layer 708 and the second polymer layer 726. In some embodiments, the second polymer layer can extend between adjacent conductive loops, such as theconductive loop 772A and the conductive loop 772B and/or the conductive loop 772B and theconductive loop 772C, in the plurality ofconductive loops 772. With this arrangement, the second polymer layer 726 may bond to thefirst polymer layer 708 between the adjacent conductive loops in the plurality ofconductive loops 772. - After the second polymer layer 726 is formed, the
fabrication device 700 may cure the second polymer layer 726. In an example, the second polymer layer 726 can be cured like thefirst polymer layer 708. However, in other examples, the second polymer layer 726 may be cured by different techniques than thefirst polymer layer 708. The second polymer layer 726 can be cured by any of the techniques mentioned herein. In an example, thefabrication device 700 may cure thefirst polymer layer 708 at this stage. - After the second polymer layer 726 is cured, there may not be a visible boundary line separating the
first polymer layer 708 from the second polymer layer 726. As noted,FIG. 3 a illustrates the eye-mountable device 310. In particular,FIG. 3 a illustrates the eye-mountable device 300 includes thetransparent polymer 320. Thetransparent polymer 320 can be arranged like thefirst polymer layer 708 and the second polymer layer 726. - Returning to
FIG. 7 e, thefabrication device 700 may further comprise one or more alignment pins (not shown), such as a plurality of dowel pins, for aligning thethird molding piece 722 and thefirst molding piece 702. The one or more alignment pins can assist in forming the second polymer layer 726 by aligning thethird molding piece 722 with thefirst molding piece 702. - The
first molding piece 702 and thethird molding piece 722 may be configured to achieve a given desired thickness of a layer formed between the two pieces. As one example, thefirst molding piece 702 and thethird molding piece 722 may be designed so as to define a thickness of the second polymer layer 726. As another example, thefirst molding piece 702 and thethird molding piece 722 may be designed so as to define a final thickness of an eye-mountable device, such as the eye-mountable device 310. In an example, thefirst molding piece 702 and thethird molding piece 722 can be designed so as to allow for a layer having a given desired thickness between the two pieces (in addition to a thickness of the first polymer 708). As such, when thefirst molding piece 702 and thethird molding piece 722 are pressed together during formation of a layer, the resulting layer will have the given desired thickness. - In an example, the second polymer layer 726 has a thickness of greater than 50 micrometers. However, in other examples, the second polymer layer 726 can have a thickness between 50 and 300 micrometers, such as 130 micrometers. It should be understood that since the second polymer layer 726 molds over the
structure 730, the second polymer layer 726 may not have a uniform thickness. For instance, the thickness of the second polymer layer 726 above thesensor 760 may be less than the thickness of the second polymer layer 726 that is not touching thesensor 760. - In an example, the thickness of the second polymer layer 726 can be selected based on a particular analyte or analytes that the eye-mountable device, such as the eye-
mountable device 310, is configured to detect. For example, an optimal thickness for a first analyte may be 10 micrometers, while an optimal thickness for a second analyte may be 25 micrometers. Other examples are possible as well. - In an example, the second polymer layer 726 can be composed of the same polymer material as the
first polymer layer 708. However, in other examples, the second polymer layer 726 can be composed of a different polymer material than thefirst polymer layer 708. The second polymer layer 726 can be any one of the polymer materials mentioned herein. In an example, thestructure 730 can be more rigid than the second polymer layer 726. - The second polymer layer 726 defines an anterior side 728 of an eye-mountable device. That is, the second polymer layer 726 defines an outer edge of the eye-mountable device. When mounted on an eye of a user, the anterior side 728 of the eye-mountable device defined by the second polymer layer 726 corresponds to the side of the device that is not touching the eye of the user. The
third molding piece 722 may be shaped so as to define a shape of the anterior side 728. For example, a curvature of the anterior side 728 may be defined by thethird molding piece 722. - E. Forming the First Polymer Layer and the Second Polymer Layer at the Same Time
- The example methods described above involve a method of fabricating an eye-mountable device that involves first forming a first polymer layer and subsequently forming a second polymer layer. In another example, the first polymer layer defining a posterior side of the eye-mountable device and the second polymer layer defining an anterior side of the eye-mountable device may be substantially formed around a structure, such as the
structure 730, at the same time. The term “substantially formed,” as used in this disclosure, refers to exactly formed and/or one or more deviations from exactly formed that do not significantly impact embedding a structure in a body-mountable device as described herein. Further, in such an example, positioning the structure on the first layer and conforming the structure positioned on the first layer to a curvature of the first layer would take place at the same time as the formation of the first polymer layer and the second polymer layer. - For instance, in accordance with an example embodiment, the fabrication device may be configured to position a structure within a molding cavity or cavities, and the fabrication device may then form the first polymer layer and the second polymer layer around the structure. In such an example, the fabrication device may be configured to inject mold into the molding cavity, and the injected mold may encapsulate the structure. In this example, the fabrication device may include a molding cavity or cavities that have at least one opening configured to allow the fabrication device to hold the structure in place as the first and second polymer layers are formed around the structure. The molding cavity or cavities may be filled with the polymer material, and this introduction of the polymer material may form the polymer layers around the structure.
- F. Forming a Channel Through the Second Polymer Layer
- In some embodiments, the example methods described above may further include forming a channel through a second polymer layer, such that a sensor (e.g., sensor 760), is configured to receive one or more analytes via the channel. In such an example, the channel may be formed by removing material from the second polymer layer. The material from the second polymer layer can be removed to form the channel in a variety of ways. For instance, the material from the second polymer layer can be removed to form the channel via a process that includes drilling, ablation, etching, etc.
- In another example, a mask layer may be formed before forming the second polymer layer. Further, in such an example, after the second polymer layer is formed, the mask layer may be removed to form a channel. The mask layer can be removed to form the channel in a variety of ways. For instance, the mask layer can be removed to form the channel via a process that includes etching the mask layer and/or dissolving the mask layer in a fluid.
- It should be understood that arrangements described herein are for purposes of example only. As such, those skilled in the art will appreciate that other arrangements and other elements (e.g., machines, interfaces, functions, orders, and groupings of functions, etc.) can be used instead, and some elements may be omitted altogether according to the desired results. Further, many of the elements that are described are functional entities that may be implemented as discrete or distributed components or in conjunction with other components, in any suitable combination and location.
- While various aspects and embodiments have been disclosed herein, other aspects and embodiments will be apparent to those skilled in the art. The various aspects and embodiments disclosed herein are for purposes of illustration and are not intended to be limiting, with the true scope and spirit being indicated by the following claims, along with the full scope of equivalents to which such claims are entitled. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to be limiting.
- Where example embodiments involve information related to a person or a device of a person, some embodiments may include privacy controls. Such privacy controls may include, at least, anonymization of device identifiers, transparency and user controls, including functionality that would enable users to modify or delete information relating to the user's use of a product.
- Further, in situations in where embodiments discussed herein collect personal information about users, or may make use of personal information, the users may be provided with an opportunity to control whether programs or features collect user information (e.g., information about a user's medical history, social network, social actions or activities, profession, a user's preferences, or a user's current location), or to control whether and/or how to receive content from the content server that may be more relevant to the user. In addition, certain data may be treated in one or more ways before it is stored or used, so that personally identifiable information is removed. For example, a user's identity may be treated so that no personally identifiable information can be determined for the user, or a user's geographic location may be generalized where location information is obtained (such as to a city, ZIP code, or state level), so that a particular location of a user cannot be determined. Thus, the user may have control over how information is collected about the user and used by a content server.
Claims (26)
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Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USD754861S1 (en) * | 2014-10-07 | 2016-04-26 | Verily Life Sciences Llc | Contact lens antenna |
US20160332272A1 (en) * | 2015-05-13 | 2016-11-17 | The Boeing Company | Surface Area of Fixtures |
US9656359B1 (en) * | 2013-12-17 | 2017-05-23 | Verily Life Sciences, LLP | Devices and systems for lens support |
US9696564B1 (en) | 2012-08-21 | 2017-07-04 | Verily Life Sciences Llc | Contact lens with metal portion and polymer layer having indentations |
US10034625B1 (en) * | 2014-09-22 | 2018-07-31 | Verily Life Sciences Llc | Aptamer-based analyte detection system and sensor |
US10278644B1 (en) * | 2014-02-25 | 2019-05-07 | Verily Life Sciences Llc | Methods for providing a dyed polymer layer |
US10505394B2 (en) * | 2018-04-21 | 2019-12-10 | Tectus Corporation | Power generation necklaces that mitigate energy absorption in the human body |
US10644543B1 (en) | 2018-12-20 | 2020-05-05 | Tectus Corporation | Eye-mounted display system including a head wearable object |
US10790700B2 (en) | 2018-05-18 | 2020-09-29 | Tectus Corporation | Power generation necklaces with field shaping systems |
US10838239B2 (en) | 2018-04-30 | 2020-11-17 | Tectus Corporation | Multi-coil field generation in an electronic contact lens system |
US10838232B2 (en) | 2018-11-26 | 2020-11-17 | Tectus Corporation | Eye-mounted displays including embedded solenoids |
US10845621B1 (en) | 2019-08-02 | 2020-11-24 | Tectus Corporation | Headgear providing inductive coupling to a contact lens, with controller |
US10895762B2 (en) | 2018-04-30 | 2021-01-19 | Tectus Corporation | Multi-coil field generation in an electronic contact lens system |
US11137622B2 (en) | 2018-07-15 | 2021-10-05 | Tectus Corporation | Eye-mounted displays including embedded conductive coils |
US11602427B2 (en) * | 2018-03-30 | 2023-03-14 | Qura, Inc. | Intraocular lenses including an intraocular pressure sensor |
EP4290297A1 (en) * | 2022-06-12 | 2023-12-13 | Pegavision Corporation | Contact lens |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9823737B2 (en) * | 2008-04-07 | 2017-11-21 | Mohammad A Mazed | Augmented reality personal assistant apparatus |
US9812096B2 (en) | 2008-01-23 | 2017-11-07 | Spy Eye, Llc | Eye mounted displays and systems using eye mounted displays |
CA153773S (en) * | 2013-05-17 | 2014-09-10 | Johnson & Johnson Vision Care | Contact lens |
US9993335B2 (en) | 2014-01-08 | 2018-06-12 | Spy Eye, Llc | Variable resolution eye mounted displays |
US9907498B2 (en) * | 2014-09-04 | 2018-03-06 | Verily Life Sciences Llc | Channel formation |
US20160174842A1 (en) * | 2014-12-17 | 2016-06-23 | Elwha Llc | Epidermal electronics systems having radio frequency antennas systems and methods |
JP2019505010A (en) | 2015-11-11 | 2019-02-21 | ワンフォーカス ビジョン, インコーポレイテッド | Perspective adjustment lens with cavity |
US10658736B2 (en) * | 2016-11-06 | 2020-05-19 | The Boeing Company | Dominant H-field multiband loop antenna including passive mixer |
US10649233B2 (en) | 2016-11-28 | 2020-05-12 | Tectus Corporation | Unobtrusive eye mounted display |
US11143885B2 (en) * | 2017-09-25 | 2021-10-12 | Verily Life Sciences Llc | Smart contact lens with antenna and sensor |
JP7219230B2 (en) * | 2017-12-22 | 2023-02-07 | ソニーグループ株式会社 | contact lenses and communication systems |
US10673414B2 (en) | 2018-02-05 | 2020-06-02 | Tectus Corporation | Adaptive tuning of a contact lens |
CA3093903A1 (en) | 2018-03-14 | 2019-09-19 | Menicon Singapore Pte Ltd. | Wearable device for communication with an ophthalmic device |
US10529107B1 (en) | 2018-09-11 | 2020-01-07 | Tectus Corporation | Projector alignment in a contact lens |
EP3876780B1 (en) * | 2018-11-09 | 2022-10-12 | Alcon Inc. | Lens care container |
EP3973872A1 (en) * | 2020-09-28 | 2022-03-30 | Roche Diabetes Care GmbH | Method for manufacturing a sensor base plate for an in vivo analyte sensing device |
Family Cites Families (188)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4055378A (en) | 1971-12-31 | 1977-10-25 | Agfa-Gevaert Aktiengesellschaft | Silicone contact lens with hydrophilic surface treatment |
US4122942A (en) | 1974-01-31 | 1978-10-31 | Wolfson Leonard G | Hydrophilic contact lens case |
US4014321A (en) | 1974-11-25 | 1977-03-29 | March Wayne F | Non-invasive glucose sensor system |
US3958560A (en) | 1974-11-25 | 1976-05-25 | Wayne Front March | Non-invasive automatic glucose sensor system |
US4143949A (en) | 1976-10-28 | 1979-03-13 | Bausch & Lomb Incorporated | Process for putting a hydrophilic coating on a hydrophobic contact lens |
US4136250A (en) | 1977-07-20 | 1979-01-23 | Ciba-Geigy Corporation | Polysiloxane hydrogels |
US4153641A (en) | 1977-07-25 | 1979-05-08 | Bausch & Lomb Incorporated | Polysiloxane composition and contact lens |
DE2756114B1 (en) | 1977-12-16 | 1979-05-23 | Titmus Eurocon Kontaktlinsen | Process for the surface treatment of a hard or dehydrated hydrophilic contact lens |
US4309085A (en) | 1979-07-12 | 1982-01-05 | Morrison Robert J | Method for measuring eye features with a contact lens |
US4312575A (en) | 1979-09-18 | 1982-01-26 | Peyman Gholam A | Soft corneal contact lens with tightly cross-linked polymer coating and method of making same |
US4401371A (en) | 1979-09-24 | 1983-08-30 | Neefe Charles W | Hydrogel oxygen generator with improved fluid flow |
US4555372A (en) | 1981-03-23 | 1985-11-26 | Bausch & Lomb Incorporated | Rotational molding of contact lenses |
US4604479A (en) | 1981-12-04 | 1986-08-05 | Polymer Technology Corporation | Silicone-containing contact lens material and contact lenses made thereof |
US4826936A (en) | 1981-12-04 | 1989-05-02 | Polymer Technology Corp. | Silicone-containing contact lens material and contact lenses made thereof |
US4463149A (en) | 1982-03-29 | 1984-07-31 | Polymer Technology Corporation | Silicone-containing contact lens material and contact lenses made thereof |
JPS60163901A (en) | 1984-02-04 | 1985-08-26 | Japan Synthetic Rubber Co Ltd | Plasma polymerization treatment |
US4686267A (en) | 1985-10-11 | 1987-08-11 | Polymer Technology Corporation | Fluorine containing polymeric compositions useful in contact lenses |
US4996275A (en) | 1985-10-11 | 1991-02-26 | Polymer Technology Corporation | Fluorine containing polymeric compositions useful in contact lenses |
US4740533A (en) | 1987-07-28 | 1988-04-26 | Ciba-Geigy Corporation | Wettable, flexible, oxygen permeable, substantially non-swellable contact lens containing block copolymer polysiloxane-polyoxyalkylene backbone units, and use thereof |
CA1305873C (en) | 1987-05-26 | 1992-08-04 | Howel Gwynne Giles | Method and means for detecting alcohol levels in humans |
US5018849A (en) | 1988-11-16 | 1991-05-28 | Ciba-Geigy Corporation | Colored contact lens and methods of making the same |
US4979516A (en) | 1989-03-30 | 1990-12-25 | Abraham Ii James G | Pressure sensitive mouth piece |
US5326584A (en) | 1989-04-24 | 1994-07-05 | Drexel University | Biocompatible, surface modified materials and method of making the same |
GB8909491D0 (en) | 1989-04-26 | 1989-06-14 | Glynn Christopher J | Device for real-time monitoring of human or animal bodily functions |
US5070215A (en) | 1989-05-02 | 1991-12-03 | Bausch & Lomb Incorporated | Novel vinyl carbonate and vinyl carbamate contact lens material monomers |
US5034461A (en) | 1989-06-07 | 1991-07-23 | Bausch & Lomb Incorporated | Novel prepolymers useful in biomedical devices |
US5032658A (en) | 1989-10-17 | 1991-07-16 | Polymer Technology Corporation | Polymeric compositions useful in oxygen permeable contact lenses |
US5177168A (en) | 1989-10-17 | 1993-01-05 | Polymer Technology Corp. | Polymeric compositions useful in oxygen permeable contact lenses |
US5217015A (en) * | 1990-06-08 | 1993-06-08 | Kaye David B | Pressure sensing device having transducer overlying and deforming eye |
US5219965A (en) | 1990-11-27 | 1993-06-15 | Bausch & Lomb Incorporated | Surface modification of polymer objects |
US5177165A (en) | 1990-11-27 | 1993-01-05 | Bausch & Lomb Incorporated | Surface-active macromonomers |
US5135297A (en) | 1990-11-27 | 1992-08-04 | Bausch & Lomb Incorporated | Surface coating of polymer objects |
US5271875A (en) | 1991-09-12 | 1993-12-21 | Bausch & Lomb Incorporated | Method for molding lenses |
US5310779A (en) | 1991-11-05 | 1994-05-10 | Bausch & Lomb Incorporated | UV curable crosslinking agents useful in copolymerization |
US5358995A (en) | 1992-05-15 | 1994-10-25 | Bausch & Lomb Incorporated | Surface wettable silicone hydrogels |
US5260000A (en) | 1992-08-03 | 1993-11-09 | Bausch & Lomb Incorporated | Process for making silicone containing hydrogel lenses |
US5336797A (en) | 1992-12-30 | 1994-08-09 | Bausch & Lomb Incorporated | Siloxane macromonomers |
US5321108A (en) | 1993-02-12 | 1994-06-14 | Bausch & Lomb Incorporated | Fluorosilicone hydrogels |
US5346976A (en) | 1993-03-29 | 1994-09-13 | Polymer Technology Corporation | Itaconate copolymeric compositions for contact lenses |
US5616757A (en) | 1993-04-08 | 1997-04-01 | Bausch & Lomb Incorporated | Organosilicon-containing materials useful for biomedical devices |
TW253849B (en) | 1993-08-09 | 1995-08-11 | Ciba Geigy | |
AU1373195A (en) | 1993-12-21 | 1995-07-10 | Bausch & Lomb Incorporated | Method for increasing hydrophilicity of contact lenses |
US5472436A (en) | 1994-07-26 | 1995-12-05 | Fremstad; Daria A. | Ocular appliance for delivering medication |
US5760100B1 (en) | 1994-09-06 | 2000-11-14 | Ciba Vision Corp | Extended wear ophthalmic lens |
US5646633A (en) * | 1995-04-05 | 1997-07-08 | Mcdonnell Douglas Corporation | Microstrip antenna having a plurality of broken loops |
US5585871A (en) | 1995-05-26 | 1996-12-17 | Linden; Harry | Multi-function display apparatus |
WO1997020852A1 (en) | 1995-12-07 | 1997-06-12 | Bausch & Lomb Incorporated | Monomeric units useful for reducing the modulus of silicone hydrogels |
WO1997020851A1 (en) | 1995-12-07 | 1997-06-12 | Bausch & Lomb Incorporated | Monomeric units useful for reducing the modulus of low water polymeric silicone compositions |
US5682210A (en) | 1995-12-08 | 1997-10-28 | Weirich; John | Eye contact lens video display system |
US6544193B2 (en) | 1996-09-04 | 2003-04-08 | Marcio Marc Abreu | Noninvasive measurement of chemical substances |
US6120460A (en) | 1996-09-04 | 2000-09-19 | Abreu; Marcio Marc | Method and apparatus for signal acquisition, processing and transmission for evaluation of bodily functions |
US5708094A (en) | 1996-12-17 | 1998-01-13 | Bausch & Lomb Incorporated | Polybutadiene-based compositions for contact lenses |
US5981669A (en) | 1997-12-29 | 1999-11-09 | Bausch & Lomb Incorporated | Silicone-containing prepolymers and low water materials |
US5935155A (en) | 1998-03-13 | 1999-08-10 | John Hopkins University, School Of Medicine | Visual prosthesis and method of using same |
US6614408B1 (en) | 1998-03-25 | 2003-09-02 | W. Stephen G. Mann | Eye-tap for electronic newsgathering, documentary video, photojournalism, and personal safety |
US6131580A (en) | 1998-04-17 | 2000-10-17 | The University Of Washington | Template imprinted materials by RFGD plasma deposition |
ID26512A (en) | 1998-05-05 | 2001-01-11 | Bausch & Lomb | PLASMA SURFACE TREATMENT IN HYDRAULIC SILICONE CONTACT LENS |
US6348507B1 (en) | 1998-05-05 | 2002-02-19 | Bausch & Lomb Incorporated | Surface treatment of silicone hydrogel contact lenses |
US7398119B2 (en) | 1998-07-13 | 2008-07-08 | Childrens Hospital Los Angeles | Assessing blood brain barrier dynamics or identifying or measuring selected substances, including ethanol or toxins, in a subject by analyzing Raman spectrum signals |
US6087941A (en) | 1998-09-01 | 2000-07-11 | Ferraz; Mark | Warning device for alerting a person falling asleep |
US6366794B1 (en) | 1998-11-20 | 2002-04-02 | The University Of Connecticut | Generic integrated implantable potentiostat telemetry unit for electrochemical sensors |
US6532298B1 (en) | 1998-11-25 | 2003-03-11 | Iridian Technologies, Inc. | Portable authentication device and method using iris patterns |
US6550915B1 (en) | 1998-12-21 | 2003-04-22 | Bausch & Lomb Incorporated | Surface treatment of fluorinated contact lens materials |
US6450642B1 (en) | 1999-01-12 | 2002-09-17 | California Institute Of Technology | Lenses capable of post-fabrication power modification |
DE19921399C2 (en) | 1999-05-07 | 2003-12-18 | Univ Eberhard Karls | Retinal implant |
US6630243B2 (en) | 1999-05-20 | 2003-10-07 | Bausch & Lomb Incorporated | Surface treatment of silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating |
US6213604B1 (en) | 1999-05-20 | 2001-04-10 | Bausch & Lomb Incorporated | Plasma surface treatment of silicone hydrogel contact lenses with a flexible carbon coating |
US6440571B1 (en) | 1999-05-20 | 2002-08-27 | Bausch & Lomb Incorporated | Surface treatment of silicone medical devices with reactive hydrophilic polymers |
US6200626B1 (en) | 1999-05-20 | 2001-03-13 | Bausch & Lomb Incorporated | Surface-treatment of silicone medical devices comprising an intermediate carbon coating and graft polymerization |
US6851805B2 (en) | 1999-07-02 | 2005-02-08 | E-Vision, Llc | Stabilized electro-active contact lens |
US6300914B1 (en) * | 1999-08-12 | 2001-10-09 | Apti, Inc. | Fractal loop antenna |
US20020007113A1 (en) | 1999-08-26 | 2002-01-17 | March Wayne Front | Ocular analyte sensor |
WO2001016641A1 (en) | 1999-08-31 | 2001-03-08 | Johnson & Johnson Vision Care, Inc. | Rotationally stabilized contact lenses |
US6579235B1 (en) | 1999-11-01 | 2003-06-17 | The Johns Hopkins University | Method for monitoring intraocular pressure using a passive intraocular pressure sensor and patient worn monitoring recorder |
AU1583601A (en) | 1999-11-05 | 2001-06-06 | Bausch & Lomb Incorporated | Surface treatment of non-plasma treated silicone hydrogel contact lenses |
US6431705B1 (en) | 1999-11-10 | 2002-08-13 | Infoeye | Eyewear heart rate monitor |
US6982058B2 (en) | 1999-12-08 | 2006-01-03 | Baxter International, Inc. | Method for fabricating three dimensional structures |
US6939299B1 (en) | 1999-12-13 | 2005-09-06 | Kurt Petersen | Implantable continuous intraocular pressure sensor |
US7998412B2 (en) | 2000-01-07 | 2011-08-16 | Smart Holograms Limited | Ophthalmic device comprising a holographic sensor |
US6735328B1 (en) | 2000-03-07 | 2004-05-11 | Agilent Technologies, Inc. | Personal viewing device with system for providing identification information to a connected system |
US6599559B1 (en) | 2000-04-03 | 2003-07-29 | Bausch & Lomb Incorporated | Renewable surface treatment of silicone medical devices with reactive hydrophilic polymers |
US6428839B1 (en) | 2000-06-02 | 2002-08-06 | Bausch & Lomb Incorporated | Surface treatment of medical device |
US6779888B2 (en) | 2000-07-28 | 2004-08-24 | Ocular Sciences, Inc. | Contact lenses with microchannels |
US6749568B2 (en) | 2000-08-21 | 2004-06-15 | Cleveland Clinic Foundation | Intraocular pressure measurement system including a sensor mounted in a contact lens |
MXPA03002322A (en) | 2000-09-19 | 2003-06-24 | Bausch & Lomb | Method for applying polymeric lens coating. |
WO2002027388A1 (en) | 2000-09-28 | 2002-04-04 | Novartis Ag | Fenestrated lens for increased tear flow and method for making the same |
JP5079970B2 (en) | 2001-06-29 | 2012-11-21 | エコール ポリテクニーク フェデラル ドゥ ローザンヌ(エーペーエフエル) | Intraocular pressure recording device |
US6885818B2 (en) | 2001-07-30 | 2005-04-26 | Hewlett-Packard Development Company, L.P. | System and method for controlling electronic devices |
US6570386B2 (en) | 2001-07-30 | 2003-05-27 | Hewlett-Packard Development Company, L.P. | System and method for providing power to electrical devices |
US20030116447A1 (en) | 2001-11-16 | 2003-06-26 | Surridge Nigel A. | Electrodes, methods, apparatuses comprising micro-electrode arrays |
AU2003214977A1 (en) | 2002-02-05 | 2003-09-02 | Lace Elettronica S.R.L. | Glaucoma screening system and method |
US20030179094A1 (en) | 2002-03-08 | 2003-09-25 | Abreu Marcio Marc | Signal-to-product coupling |
TW200304385A (en) | 2002-03-13 | 2003-10-01 | Novartis Ag | Materials containing multiple layers of vesicles |
CA2494934A1 (en) | 2002-08-09 | 2004-02-19 | E-Vision, Llc | Electro-active contact lens system |
US7429465B2 (en) | 2002-09-13 | 2008-09-30 | Novartis Ag | Process for analyzing tear fluid |
US7964390B2 (en) | 2002-10-11 | 2011-06-21 | Case Western Reserve University | Sensor system |
US7131945B2 (en) | 2002-10-16 | 2006-11-07 | California Institute Of Technology | Optically powered and optically data-transmitting wireless intraocular pressure sensor device |
US6958169B2 (en) | 2002-12-17 | 2005-10-25 | Bausch & Lomb Incorporated | Surface treatment of medical device |
EP1589866A2 (en) | 2003-01-09 | 2005-11-02 | The Regents of the University of California | Implantable devices and methods for measuring intraocular, subconjunctival or subdermal pressure and/or analyte concentration |
WO2004064629A1 (en) | 2003-01-21 | 2004-08-05 | Ehrfeld Miktotechnik Ag | Sensor system for detecting analytes in tear fluid |
US20040181172A1 (en) | 2003-03-12 | 2004-09-16 | Carney Fiona Patricia | Devices for collecting analytes of interest in tears |
US7127301B1 (en) | 2003-04-28 | 2006-10-24 | Sandia Corporation | Flexible retinal electrode array |
ATE407417T1 (en) | 2003-05-26 | 2008-09-15 | Securecom Technologies Ltd | PORTABLE COMMUNICATION DEVICE |
DE10329615A1 (en) | 2003-06-23 | 2005-03-03 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Active retina implant with a variety of picture elements |
ATE520661T1 (en) | 2003-06-27 | 2011-09-15 | Univ Maryland | HETEROCYCLIC COMPOUNDS WITH QUATERNARY NITROGEN FOR THE DETECTION OF AQUEOUS MONOSACHARIDES IN PHYSIOLOGICAL LIQUIDS |
EP1651946A1 (en) | 2003-07-30 | 2006-05-03 | Novartis AG | Reflection hologram sensor in contact lens |
DE602004028020D1 (en) | 2003-08-07 | 2010-08-19 | Eyesense Ag | OPHTHALMIC SENSOR |
US7250197B2 (en) | 2003-08-25 | 2007-07-31 | Bausch & Lomb Incorporated | Plasma treatment of contact lens and IOL |
US7289260B2 (en) | 2003-10-03 | 2007-10-30 | Invisia Ltd. | Multifocal lens |
US6992630B2 (en) * | 2003-10-28 | 2006-01-31 | Harris Corporation | Annular ring antenna |
US7601274B2 (en) | 2004-03-31 | 2009-10-13 | The University Of Connecticut | Shape memory main-chain smectic-C elastomers |
WO2006015315A2 (en) | 2004-07-30 | 2006-02-09 | University Of Rochester Medical Center | Intraocular video system |
JP4455216B2 (en) | 2004-08-06 | 2010-04-21 | キヤノン株式会社 | Detection device |
KR20060044058A (en) | 2004-11-11 | 2006-05-16 | 삼성전자주식회사 | Blood components measuring apparatus and method using trans-reflectance |
GB2422660C (en) | 2005-01-27 | 2018-04-25 | H Icheck Ltd | Improved device for monitoring body functions |
US20060183986A1 (en) | 2005-02-11 | 2006-08-17 | Rice Mark J | Intraocular lens measurement of blood glucose |
WO2006102495A2 (en) | 2005-03-24 | 2006-09-28 | Massachusetts Institute Of Technology | Device and method for tracking eye gaze direction |
TWI249772B (en) | 2005-06-07 | 2006-02-21 | Siliconware Precision Industries Co Ltd | Semiconductor device for accommodating large chip, fabrication method thereof, and carrier used in the semiconductor device |
US20080218696A1 (en) | 2005-07-01 | 2008-09-11 | Jose Mir | Non-Invasive Monitoring System |
AU2006311850B2 (en) | 2005-11-02 | 2011-06-16 | Second Sight Medical Products, Inc. | Implantable microelectronic device and method of manufacture |
US7384145B2 (en) | 2006-02-16 | 2008-06-10 | The Board Of Trustees Of The University Of Illinois | Mapping retinal function using corneal electrode array |
US8118752B2 (en) | 2006-02-16 | 2012-02-21 | The Board Of Trustees Of The University Of Illinois | Apparatus and methods for mapping retinal function |
US7885698B2 (en) | 2006-02-28 | 2011-02-08 | Abbott Diabetes Care Inc. | Method and system for providing continuous calibration of implantable analyte sensors |
GB0604845D0 (en) | 2006-03-10 | 2006-04-19 | Ocutec Ltd | Polymeric Materials |
US8224415B2 (en) | 2009-01-29 | 2012-07-17 | Abbott Diabetes Care Inc. | Method and device for providing offset model based calibration for analyte sensor |
CA2587097A1 (en) | 2006-04-12 | 2007-10-12 | Rikke Dootjes | Lens |
TW200741278A (en) | 2006-04-28 | 2007-11-01 | Wei-Bin Shiu | Contact lenses |
WO2007136993A1 (en) | 2006-05-17 | 2007-11-29 | Mayo Foundation For Medical Education And Research | Monitoring intraocular pressure |
US7878650B2 (en) | 2006-06-29 | 2011-02-01 | Fritsch Michael H | Contact lens materials, designs, substances, and methods |
US20110274680A1 (en) | 2009-10-02 | 2011-11-10 | Mazed Mohammad A | Chemical composition and its delivery for lowering the risks of alzheimer's, cardiov ascular and type-2 diabetes diseases |
WO2008086090A1 (en) | 2007-01-05 | 2008-07-17 | University Of Washington | Self-assembled heterogeneous integrated optical analysis system |
DE102007003341B4 (en) | 2007-01-17 | 2018-01-04 | Eyesense Ag | Eyepiece sensor and measuring system for detecting an analyte in an eye fluid |
AR064986A1 (en) | 2007-01-22 | 2009-05-06 | Pixeloptics Inc | CHOLESTERIC LIQUID CRYSTAL MATERIAL IN ELECTROACTIVE LENS |
AR064985A1 (en) | 2007-01-22 | 2009-05-06 | E Vision Llc | FLEXIBLE ELECTROACTIVE LENS |
WO2008103906A2 (en) | 2007-02-23 | 2008-08-28 | Pixeloptics, Inc. | Ophthalmic dynamic aperture |
WO2008109867A2 (en) | 2007-03-07 | 2008-09-12 | University Of Washington | Active contact lens |
US8446341B2 (en) | 2007-03-07 | 2013-05-21 | University Of Washington | Contact lens with integrated light-emitting component |
US8679859B2 (en) | 2007-03-12 | 2014-03-25 | State of Oregon by and through the State Board of Higher Education on behalf of Porland State University | Method for functionalizing materials and devices comprising such materials |
US8689971B2 (en) | 2007-08-31 | 2014-04-08 | Novartis Ag | Contact lens packaging solutions |
CA2703840A1 (en) | 2007-11-02 | 2009-05-07 | Edwards Lifesciences Corporation | Analyte monitoring system having back-up power source for use in either transport of the system or primary power loss |
US8608310B2 (en) | 2007-11-07 | 2013-12-17 | University Of Washington Through Its Center For Commercialization | Wireless powered contact lens with biosensor |
US8579434B2 (en) | 2007-11-07 | 2013-11-12 | University Of Washington Through Its Center For Commercialization | Free-standing two-sided device fabrication |
US20090196460A1 (en) | 2008-01-17 | 2009-08-06 | Thomas Jakobs | Eye tracking system and method |
WO2009094587A1 (en) | 2008-01-23 | 2009-07-30 | Deering Michael F | Eye mounted displays |
WO2009094643A2 (en) | 2008-01-26 | 2009-07-30 | Deering Michael F | Systems using eye mounted displays |
TWI511869B (en) | 2008-02-20 | 2015-12-11 | Johnson & Johnson Vision Care | Energized biomedical device |
WO2009111726A2 (en) | 2008-03-06 | 2009-09-11 | The Regents Of The University Of California | Measuring outlflow resistance/facility of an eye |
EP2271964A4 (en) | 2008-03-18 | 2017-09-20 | Mitsui Chemicals, Inc. | Advanced electro-active optic device |
US7931832B2 (en) | 2008-03-31 | 2011-04-26 | Johnson & Johnson Vision Care, Inc. | Ophthalmic lens media insert |
ES2330405B1 (en) | 2008-06-06 | 2010-09-21 | Consejo Superior De Investigaciones Cientificas (Csic) (45%) | SENSOR CONTACT LENS, SYSTEM FOR NON-INVASIVE MONITORING OF INTRAOCULAR PRESSURE AND METHOD TO PUT YOUR MEASUREMENT. |
US20100016704A1 (en) | 2008-07-16 | 2010-01-21 | Naber John F | Method and system for monitoring a condition of an eye |
US8142016B2 (en) | 2008-09-04 | 2012-03-27 | Innovega, Inc. | Method and apparatus for constructing a contact lens with optics |
US9296158B2 (en) | 2008-09-22 | 2016-03-29 | Johnson & Johnson Vision Care, Inc. | Binder of energized components in an ophthalmic lens |
CA2683467C (en) | 2008-10-24 | 2016-01-26 | Jin Zhang | Contact lens integrated with a biosensor for detection of glucose and other components in tears |
US8092013B2 (en) | 2008-10-28 | 2012-01-10 | Johnson & Johnson Vision Care, Inc. | Apparatus and method for activation of components of an energized ophthalmic lens |
US9375885B2 (en) | 2008-10-31 | 2016-06-28 | Johnson & Johnson Vision Care, Inc. | Processor controlled ophthalmic device |
US9375886B2 (en) | 2008-10-31 | 2016-06-28 | Johnson & Johnson Vision Care Inc. | Ophthalmic device with embedded microcontroller |
US8169006B2 (en) | 2008-11-29 | 2012-05-01 | Electronics And Telecommunications Research Institute | Bio-sensor chip for detecting target material |
US20110295090A1 (en) | 2008-12-04 | 2011-12-01 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems, devices, and methods including implantable devices with anti-microbial properties |
CN102355854B (en) | 2009-01-21 | 2015-04-01 | 加州理工学院 | Pocket-enabled chip assembly for implantable devices |
US20100234942A1 (en) | 2009-03-11 | 2010-09-16 | Peyman Gholam A | Transition lenses with virtual pupil |
WO2010105728A2 (en) | 2009-03-20 | 2010-09-23 | Retina Implant Ag | Active retinal implant |
CA2756351A1 (en) | 2009-03-26 | 2010-09-30 | Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acti Ng For And On Behalf Of Arizona State University | Integrated device for surface-contact sampling, extraction and electrochemical measurements |
WO2010133317A1 (en) | 2009-05-17 | 2010-11-25 | Helmut Binder | Lens with variable refraction power for the human eye |
US8461226B2 (en) | 2009-07-24 | 2013-06-11 | Bausch & Lomb Incorporated | Contact lens |
US8060560B2 (en) | 2009-08-27 | 2011-11-15 | Net Power And Light, Inc. | System and method for pervasive computing |
CA2774462A1 (en) | 2009-09-18 | 2011-03-24 | University Of Akron | Optical device and method for non-invasive real-time testing of blood sugar levels |
WO2011035228A1 (en) | 2009-09-18 | 2011-03-24 | Orthomems, Inc. | Implantable mems intraocular pressure sensor devices and methods for glaucoma monitoring |
IN2012DN03211A (en) | 2009-09-18 | 2015-10-23 | Orthomems Inc | |
US8628194B2 (en) | 2009-10-13 | 2014-01-14 | Anton Sabeta | Method and system for contact lens care and compliance |
US9968254B2 (en) | 2010-01-05 | 2018-05-15 | Sensimed Sa | Intraocular pressure monitoring device |
US9128281B2 (en) | 2010-09-14 | 2015-09-08 | Microsoft Technology Licensing, Llc | Eyepiece with uniformly illuminated reflective display |
US20110298794A1 (en) | 2010-06-08 | 2011-12-08 | Barney Freedman | Circular polarized contact lenses and methods thereof |
RU2013102532A (en) | 2010-06-20 | 2014-07-27 | Эленза, Инк. | OPHTHALMIC DEVICES AND METHODS WITH SPECIALIZED INTEGRAL CIRCUITS |
KR102139022B1 (en) | 2010-07-30 | 2020-07-29 | 알콘 인코포레이티드 | A silicone hydrogel lens with a crosslinked hydrophilic coating |
EP2412305A1 (en) | 2010-07-30 | 2012-02-01 | Ophtimalia | Integrated flexible passive sensor in a soft contact lens for IOP monitoring |
WO2012035429A2 (en) | 2010-09-13 | 2012-03-22 | The University Of British Columbia | Remotely controlled drug delivery systems |
US20120238857A1 (en) | 2010-09-16 | 2012-09-20 | Orthomems, Inc. | Expandable implantable pressure sensor for intraocular surgery |
EP3632308B1 (en) | 2010-09-29 | 2023-12-06 | Dexcom, Inc. | Advanced continuous analyte monitoring system |
SG10201508383QA (en) | 2010-10-11 | 2015-11-27 | Adlens Beacon Inc | Fluid filled adjustable contact lenses |
US9063352B2 (en) | 2010-10-11 | 2015-06-23 | The Regents Of The University Of California | Telescopic contact lens |
GB201017637D0 (en) | 2010-10-20 | 2010-12-01 | Univ Dundee | Device for monitoring intraocular pressure |
US9114004B2 (en) | 2010-10-27 | 2015-08-25 | Iridium Medical Technology Co, Ltd. | Flexible artificial retina devices |
US20120206691A1 (en) | 2011-02-10 | 2012-08-16 | Iwai Benjamin T | Dynamic multifocal contact lens |
EP2508935A1 (en) | 2011-04-08 | 2012-10-10 | Nxp B.V. | Flexible eye insert and glucose measuring system |
US9370628B2 (en) | 2011-06-05 | 2016-06-21 | University Of British Columbia | Wireless microactuators and control methods |
US8542325B2 (en) | 2011-09-29 | 2013-09-24 | Ehren Ray Burton | Color changing contact lenses |
US8857983B2 (en) * | 2012-01-26 | 2014-10-14 | Johnson & Johnson Vision Care, Inc. | Ophthalmic lens assembly having an integrated antenna structure |
-
2013
- 2013-06-14 US US13/918,522 patent/US20140371560A1/en not_active Abandoned
- 2013-09-24 US US14/035,352 patent/US9332935B2/en active Active
-
2014
- 2014-06-12 WO PCT/US2014/042152 patent/WO2014201268A1/en active Application Filing
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