WO2015176341A1

WO2015176341A1 - Application of zinc decanoate as animal feed additive

Info

Publication number: WO2015176341A1
Application number: PCT/CN2014/080473
Authority: WO
Inventors: 彭险峰; 覃宗华
Original assignee: 广州英赛特生物技术有限公司
Priority date: 2014-05-23
Filing date: 2014-06-23
Publication date: 2015-11-26
Also published as: CN104041669A; CN104041669B

Abstract

Disclosed is the application of zinc decanoate as a feed additive and a feed-use growth promoter, and especially its application in pig feed as a substitute for a high dose of zinc oxide; zinc decanoate reduces the use of zinc in animal husbandry and can decrease production costs, while also reducing the toxic side effects of high levels of zinc.

Description

Application of zinc citrate as an animal word additive

The invention belongs to the field of livestock and poultry breeding, and particularly relates to the application of zinc citrate as a word additive or the application of a word growth promoter, especially the application of a high-dose zinc oxide substitute for pigs. Background technique:

Zinc is one of the essential trace elements in animals. Zinc required for nutrition is often supplemented with inorganic zinc such as zinc sulfate in the term. Since the early 1990s, it has been found that high-dose zinc oxide can be widely used in the global literary industry after high-dose addition in weaning pigs can reduce diarrhea rate and increase daily gain. However, the problem of heavy metal pollution caused by the application of a large amount of zinc sulfate and high-dose zinc oxide has gradually gained attention. High-dose zinc oxide has been banned in the EU since recent years. Although China's weaned pigs are allowed to use 2,250 ppm of zinc, this is also a stopgap measure. Therefore, a new type of zinc source product that is efficient, safe and environmentally friendly is required for the development of modern animal husbandry. Summary of the invention:

It is an object of the present invention to provide the use of zinc phthalate as a word additive, especially as a high dose zinc oxide substitute for pigs.

The invention has found through experiments that 150ppm zinc silicate (calculated by zinc ion, the same below) can reach 750ppm zinc oxide (calculated by zinc ion, the same below) to improve the performance of the test pig. Thus, it can be seen that the zinc phthalate as an additive of the present invention can achieve a high growth rate of zinc oxide at a low dose of zinc ions.

The zinc phthalate of the invention can be used as a substitute for high-dose zinc oxide in the wording additive to play the role of anti-diarrhea and growth promoting, namely as an animal growth promoting agent and an anti-diarrheal agent, as an animal word material. Additive application.

In addition, the present invention has found for the first time that even in the range of additive levels of nutrient requirements, the promotion of zinc citrate is significantly better than that of the same dose of zinc ion donors, such as zinc sulphate, so that zinc silicate can be applied. The other stages of the pig's wording and other animal species are effective in promoting growth (less than 150 ppm zinc ion concentration range), while the same dose of zinc sulfate or other zinc-containing compounds have no such effect.

The zinc niobate is a salt having a ratio of tannic acid to zinc species of 2:1. The animal is preferably a farm animal such as a pig, a broiler or a duck.

The zinc citrate (calculated as zinc ion, the same below) has an additive amount of 15 to 2250 ppm in the animal term, and a preferred dose is 15 to 450 ppm.

The animal word material is preferably a full-price word.

The invention proves that a series of experiments prove that the application of zinc antimonate in pig vocabulary can reduce the dosage of zinc oxide by nearly 80%, and can also achieve the same production performance, can significantly reduce the application of zinc in animal husbandry, and can reduce the production cost. It reduces the toxic side effects of high zinc and reduces environmental pollution. It is a zinc compound with unique anti-diarrhea and growth-promoting advantages.

Accordingly, the present invention provides the use of zinc phthalate as a word additive and the application of a word growth promoter, particularly as a unique advantage for the use of high dose zinc oxide substitutes for pig words. detailed description:

The following examples are intended to further illustrate the invention and not to limit the invention.

Example 1 : Synthesis of zinc antimonate

0

CH ₃ (CH ₂ ) ₈ C— 0

1, NaOH, H ₂ 0 \

CH ₃ (CH ₂ ) ₈ COOH »► / ^Zn

2, ZnS0 ₄ CH ₃ (CH ₂ ) ₈ C- O

\〇

MW: 172.27 MW: 407.90 400 ml of water was added to a 1 L beaker at room temperature, and 7.6 g of sodium hydroxide (96%, O.1818 mol) was added thereto to dissolve completely, and then 30 g of citric acid (MW: 172.27, 0.174 mol) was added. After stirring for 1 h, add zinc sulfate (MW: 287.56, 0.09 lmol) aqueous solution (26.2 g of zinc sulfate heptahydrate + 100 ml of water) for about 15 minutes, continue stirring for 3 hours, let stand for 1 h, filter, wash three times, drain, 50 ° Drying in a C oven for more than 8 hours gives zinc phthalate product powder.

After 0.10 g of zinc citrate product was dissolved in 100 ml of 0.1 M HCl, the content of citric acid in the solution was determined by GC method, and the content of zinc element in the solution was determined by atomic absorption method. As a result, the molecular molar ratio of zinc ion to citric acid in the zinc ruthenate product was 1:2, that is, the structural formula of zinc phthalate was as shown in Formula 1. O

CH ₃ (CH ₂ ) ₈ C-0

Zn

CH ₃ (CH ₂ ) ₈ C-0 ^/

O

MW: 407.90 Equation 1: Zinc citrate structure

Example 2: Application effect of zinc citrate in weaned pigs

80 28-day-old weaned pigs with an average body weight of 7.65 kg and Du Changda ternary miscellaneous meat pigs with similar body weights are 1 point and 8 groups, with 10 heads in each group. Each group was added with different doses of the zinc citrate compound prepared in Example 1 in the high-zinc-free teaching material, and then fed and drank freely. The weight gain and the term reward and diarrhea of the test pigs in each test group were counted within 10 days. rate. The results are shown in Table 2. As can be seen from Table 2, 150-2250 ppm of zinc citrate (based on zinc ion, the same below) can significantly reduce the diarrhea rate of the test pig, and has a significant dose effect on the improvement of production performance. . 150ppm (as zinc ion) Zinc citrate can achieve 750ppm ZnO (as zinc ion) for improved performance in test pigs. In addition, 2250 ppm zinc citrate significantly improved diarrhea control and production performance over the same dose of zinc oxide (2250 ppm).

Table 1 Grouping test of different growth doses of zinc citrate on weanling pigs

*: The concentration of the additive is based on the additional zinc ion added after 50 ppm of the basic nutrient requirement, the same as below, -: represents a zinc compound (provided as zinc sulfate) containing only 50 ppm of zinc ions required for basic nutrition. #: Indicates the concentration of citric acid added (unit: ppm). Table 2 Results of the growth promoting effect of different doses of zinc citrate on weaned pigs

Example 3: Application effect of zinc citrate in piglets

160 heads of 55-day-old nursery houses and similar weights of Du Changda ternary miscellaneous meat pigs are shown in Table 3, 8 groups, 20 in each group. After adding different types or doses of zinc compounds to the full-price compound of the pigs without high zinc, the groups were given free access to food and water, and the weight gain and the word remuneration of the test pigs in each test group were counted for 28 days. The results are shown in Table 3. It can be seen from Table 3 that 75 ppm zinc citrate (based on zinc content, the same below) can significantly increase the daily weight gain of the test pigs, improve the word remuneration, and improve the production performance. Better than the same dose of zinc sulfate, zinc octoate, zinc laurate or zinc myristate. In addition, 150 ppm of zinc silicate improved the performance of the test pigs significantly better than the same dose of zinc sulfate.

Table 3: Results of growth-promoting effects of different doses of zinc citrate on piglets

*: The concentration of the additive is based on the additional zinc ion added after 50 ppm of the basic nutrient requirement, the same below, -:

A zinc compound (provided as zinc sulfate) that represents only 50 ppm of zinc ions required for basic nutrients.

Example 4: Application effect of zinc citrate in broiler feed

300 one-day-old fast yellow broilers (mothers) were grouped according to Table 4, with 50 in each group. After adding different types or doses of zinc compounds to the chickens with no additional zinc added, the groups were given free access to food and water, and the weight gain and term compensation of the test chickens in each test group were counted for 21 days. The results are shown in Table 5. As can be seen from Table 5, 30 and 1500 ppm of zinc antimonate (in terms of zinc, the same below) can significantly increase the daily weight gain of the test chicken, improve the feed to meat ratio, and have a significant dose effect on the improvement of production performance. However, 150 ppm zinc sulfate did not improve the performance of the test broiler.

Table 4 Experimental grouping of different doses of zinc citrate on growth promotion of broilers

* : The concentration of the additive is based on zinc ions, the same below.

Table 5 Results of the growth promoting effect of different doses of zinc citrate on broilers

Claims

Claim

1. The application of zinc citrate as an animal word additive.

2. Use according to claim 1, characterized in that the application is the use of zinc citrate as an animal word additive for animal growth promoters.

3. Use according to claim 1, characterized in that said application comprises as a vocabulary additive to meet the nutritional needs of the livestock for zinc and as a substitute for high dose zinc oxide in the vocabulary.

4. The use according to claim 1, wherein the zinc antimonate is a salt having a ratio of phthalic acid to zinc of 2:1.

5. Use according to claim 1, characterized in that the animal is a pig, a chicken or a duck.

The use according to claim 1, characterized in that the amount of the zinc citrate in the animal word is 15 to 2250 ppm based on the zinc ion content.

7. Use according to claim 6, characterized in that the zinc citrate, the amount of the additive in the animal word, is from 15 to 450 ppm in terms of zinc ion content.