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Apr 20, 2006 - Now, we know that Europeans seem to be light in skin color because of fixation of a derived allele at a locus other than MC1R. In contrast, East ...
Aug 26, 2005 - I finally read Heather Norton's review of worldwide MC1R polymorphism. In case you forgot MC1R is a locus that has been implicated in the ...
Jul 15, 2005 - Actually, my data do not show that Europeans and East Asians have different MC1R alleles, but rather that they appear to be different for two ...
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Aug 19, 2003 - I spent a little time doing research on hair color in PubMED and many of the leads seem to end up at the Melanocortin 1 receptor (MC1R).
Apr 22, 2006 - 2) One of the major loci, MC1R, is highly polymorphic in Europeans, constrained in dark-skinned populations to the ancestral consensus ...
Oct 23, 2007 - Not when it comes to red hair of course, MC1R loss-of-function mutations which turn off brown pigment production & up-regulate red-yellow ...
Mar 23, 2009 - Variant MC1R alleles show direct correlations between the biochemical signalling properties of the encoded receptor and the red-hair fair skin ...
Dec 16, 2005 - I have already pointed out that East Asians seem to be under strong selection, and moving toward fixation for Arg163gln MC1R allele (in ...
Feb 26, 2006 - If you think of it as a monogenic trait (say on MC1R), then it is just a matter of Hardy-Weinberg, p2 + 2pq + q2 = 1, so if q was the frequency of ...