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The "missing heritability" problem is the fact that single genetic variations cannot account for much of the heritability of diseases, behaviors, and other phenotypes.
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The "missing heritability" problem is the fact that single genetic variations cannot account for much of the heritability of diseases, behaviors, and other phenotypes.
by B Maher - 2008 - Cited by 1518 - Related articles
Nov 5, 2008 - Personal genomes: The case of the missing heritability. When scientists opened up the human genome, they expected to find the genetic components of common traits and diseases. But they were nowhere to be seen. Brendan Maher shines a light on six places where the missing loot could be stashed away.by TA Manolio - 2009 - Cited by 6158 - Related articles
Here we examine potential sources of missing heritability and propose research strategies, including and extending beyond current genome-wide association ...by S Sandoval-Motta - 2017 - Cited by 6 - Related articles
Jun 13, 2017 - Introduction: GWAS and the missing heritability problem. The broad-sense heritability (H2) of a phenotype is defined as the proportion of phenotypic variation that can be explained by genetic variance. A decade ago, genetic variance was almost impossible to measure accurately and was often assumed from kinship.Jul 2, 2018 - What has been and/or will be the value of identifying the sources of missing heritability? What research can and/or should be pursued to ...
Finding the Missing Heritability of Complex Diseases. Hundreds of genetic variants have been linked to common diseases through genome-wide association ...
by S Girirajan - 2017 - Cited by 3 - Related articles
May 11, 2017 - This problem of missing heritability has been haunting geneticists for about a decade, as the initial promises and high expectations from ...by O Zuk - 2012 - Cited by 1155 - Related articles
Jan 24, 2012 - Abstract. Human genetics has been haunted by the mystery of “missing heritability” of common traits. Although studies have discovered >1,200 ...by A Blanco‐Gómez - 2016 - Cited by 15 - Related articles
Prospects & Overviews. Missing heritability of complex diseases: Enlightenment by genetic variants from intermediate phenotypes. Adrián Blanco-Gómez1)2)ÃÃ,by E López-Cortegano - 2018
Jul 20, 2018 - The most common explanation for this observation is that the missing heritability corresponds to variants, either rare or common, with very small ...